hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11331.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RUNX2 | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | 5 | UniProt NCBI |
| RUNX1 | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | 5 | UniProt NCBI |
| MSX1 | Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein) | 5 | UniProt NCBI |
| FBXW12 | F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35) | 4 | UniProt NCBI |
| RUNX3 | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | 5 | UniProt NCBI |
| CBFB | Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951936 | 1.7467401872e-07 | 0.6 | RUNX1 CBFB RUNX3 | RUNX3 regulates p14-ARF |
| GO:0016513 | 9.61200410764e-07 | 0.6 | RUNX1 CBFB RUNX3 | core-binding factor complex |
| GO:0043378 | 9.61003071434e-06 | 0.6 | RUNX1 CBFB RUNX3 | positive regulation of CD8-positive, alpha-beta T cell differentiation |
| CORUM:5770 | 1.36501667663e-05 | 0.4 | RUNX1 CBFB | RUNX1-CBF-beta-DNA complex |
| REAC:R-HSA-8951911 | 1.52013220806e-05 | 0.4 | RUNX3 CBFB | RUNX3 regulates RUNX1-mediated transcription |
| REAC:R-HSA-8941333 | 4.55977246808e-05 | 0.4 | RUNX1 CBFB | RUNX2 regulates genes involved in differentiation of myeloid cells |
| REAC:R-HSA-8949275 | 4.55977246808e-05 | 0.4 | RUNX3 CBFB | RUNX3 Regulates Immune Response and Cell Migration |
| GO:0043376 | 5.37995977657e-05 | 0.6 | RUNX1 CBFB RUNX3 | regulation of CD8-positive, alpha-beta T cell differentiation |
| GO:0043374 | 8.06911104389e-05 | 0.6 | RUNX1 CBFB RUNX3 | CD8-positive, alpha-beta T cell differentiation |
| GO:2001187 | 8.06911104389e-05 | 0.6 | RUNX1 CBFB RUNX3 | positive regulation of CD8-positive, alpha-beta T cell activation |
| CORUM:6852 | 8.18785830799e-05 | 0.4 | RUNX1 CBFB | COPRS-PRMT5-RUNX1-CBFB complex |
| REAC:R-HSA-8935964 | 9.11829675208e-05 | 0.4 | RUNX1 CBFB | RUNX1 regulates expression of components of tight junctions |
| REAC:R-HSA-8939247 | 9.11829675208e-05 | 0.4 | RUNX1 CBFB | RUNX1 regulates transcription of genes involved in interleukin signaling |
| WP:WP3300 | 0.000123435780153 | 0.4 | RUNX1 CBFB | Dual hijack model of Vif in HIV infection |
| GO:0043371 | 0.000211268761872 | 0.6 | RUNX1 CBFB RUNX3 | negative regulation of CD4-positive, alpha-beta T cell differentiation |
| REAC:R-HSA-8939246 | 0.000227895019208 | 0.4 | RUNX1 CBFB | RUNX1 regulates transcription of genes involved in differentiation of myeloid cells |
| REAC:R-HSA-8939256 | 0.000227895019208 | 0.4 | RUNX1 CBFB | RUNX1 regulates transcription of genes involved in WNT signaling |
| REAC:R-HSA-8939245 | 0.000227895019208 | 0.4 | RUNX1 CBFB | RUNX1 regulates transcription of genes involved in BCR signaling |
| REAC:R-HSA-8931987 | 0.000227895019208 | 0.4 | RUNX1 CBFB | RUNX1 regulates estrogen receptor mediated transcription |
| REAC:R-HSA-8877330 | 0.000319009353903 | 0.4 | RUNX1 CBFB | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| REAC:R-HSA-8878159 | 0.000339480624615 | 0.6 | RUNX1 CBFB RUNX3 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-8939242 | 0.000425287580531 | 0.4 | RUNX1 CBFB | RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
| GO:0046639 | 0.000537554131189 | 0.6 | RUNX1 CBFB RUNX3 | negative regulation of alpha-beta T cell differentiation |
| GO:2001185 | 0.000783132248318 | 0.6 | RUNX1 CBFB RUNX3 | regulation of CD8-positive, alpha-beta T cell activation |
| GO:2000515 | 0.000929874009882 | 0.6 | RUNX1 CBFB RUNX3 | negative regulation of CD4-positive, alpha-beta T cell activation |
| HP:0008788 | 0.000961529670085 | 0.4 | RUNX2 CBFB | Delayed pubic bone ossification |
| GO:0036037 | 0.00109385703544 | 0.6 | RUNX1 CBFB RUNX3 | CD8-positive, alpha-beta T cell activation |
| REAC:R-HSA-8934593 | 0.00206313859056 | 0.4 | RUNX1 CBFB | Regulation of RUNX1 Expression and Activity |
| GO:0046636 | 0.00220577099344 | 0.6 | RUNX1 CBFB RUNX3 | negative regulation of alpha-beta T cell activation |
| HP:0009105 | 0.00230672366147 | 0.4 | RUNX2 CBFB | Abnormal ossification of the pubic bone |
| GO:0045581 | 0.00314081658857 | 0.6 | RUNX1 CBFB RUNX3 | negative regulation of T cell differentiation |
| GO:0046638 | 0.00350285844735 | 0.6 | RUNX1 CBFB RUNX3 | positive regulation of alpha-beta T cell differentiation |
| GO:0045620 | 0.00475337188383 | 0.6 | RUNX1 CBFB RUNX3 | negative regulation of lymphocyte differentiation |
| GO:0043370 | 0.00522817157061 | 0.6 | RUNX1 CBFB RUNX3 | regulation of CD4-positive, alpha-beta T cell differentiation |
| WP:WP560 | 0.00528162918062 | 0.4 | RUNX2 RUNX3 | TGF beta receptor signaling |
| WP:WP4816 | 0.00578890329638 | 0.4 | RUNX2 RUNX3 | TGF beta receptor signaling in skeletal dysplasias |
| WP:WP474 | 0.00631928190743 | 0.4 | RUNX2 RUNX3 | Endochondral ossification |
| WP:WP4808 | 0.00631928190743 | 0.4 | RUNX2 RUNX3 | Endochondral ossification with skeletal dysplasias |
| HP:0009106 | 0.00768171284681 | 0.4 | RUNX2 CBFB | Abnormal pelvis bone ossification |
| HP:0000680 | 0.00768171284681 | 0.4 | RUNX2 CBFB | Delayed eruption of primary teeth |
| HP:0006660 | 0.00870474912182 | 0.4 | RUNX2 CBFB | Aplastic clavicle |
| GO:0002062 | 0.0094606249379 | 0.6 | RUNX2 RUNX3 RUNX1 | chondrocyte differentiation |
| GO:0046637 | 0.0094606249379 | 0.6 | RUNX1 CBFB RUNX3 | regulation of alpha-beta T cell differentiation |
| REAC:R-HSA-8939243 | 0.00953234360475 | 0.4 | RUNX1 CBFB | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| GO:0046635 | 0.0109904490822 | 0.6 | RUNX1 CBFB RUNX3 | positive regulation of alpha-beta T cell activation |
| GO:2000514 | 0.011813517648 | 0.6 | RUNX1 CBFB RUNX3 | regulation of CD4-positive, alpha-beta T cell activation |
| REAC:R-HSA-8941858 | 0.0215986811086 | 0.4 | RUNX3 CBFB | Regulation of RUNX3 expression and activity |
| GO:0043367 | 0.0250826699056 | 0.6 | RUNX1 CBFB RUNX3 | CD4-positive, alpha-beta T cell differentiation |
| HP:0000894 | 0.0316815705386 | 0.4 | RUNX2 CBFB | Short clavicles |
| GO:0046634 | 0.0343879535233 | 0.6 | RUNX1 CBFB RUNX3 | regulation of alpha-beta T cell activation |
| GO:0046632 | 0.036132773595 | 0.6 | RUNX1 CBFB RUNX3 | alpha-beta T cell differentiation |
| REAC:R-HSA-9616222 | 0.0374197925333 | 0.4 | RUNX1 CBFB | Transcriptional regulation of granulopoiesis |
| GO:1902106 | 0.0379355065545 | 0.6 | RUNX1 CBFB RUNX3 | negative regulation of leukocyte differentiation |
| GO:0051216 | 0.039797089625 | 0.6 | RUNX2 RUNX3 RUNX1 | cartilage development |
| GO:1903707 | 0.039797089625 | 0.6 | RUNX1 CBFB RUNX3 | negative regulation of hemopoiesis |
| HP:0200021 | 0.0402186552091 | 0.4 | RUNX2 CBFB | Down-sloping shoulders |
| GO:0035710 | 0.0437005530348 | 0.6 | RUNX1 CBFB RUNX3 | CD4-positive, alpha-beta T cell activation |
| GO:0048934 | 0.0468008499735 | 0.4 | RUNX1 RUNX3 | peripheral nervous system neuron differentiation |
| GO:0048935 | 0.0468008499735 | 0.4 | RUNX1 RUNX3 | peripheral nervous system neuron development |
| REAC:R-HSA-8936459 | 0.0475253950332 | 0.4 | RUNX1 CBFB | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| HP:0003172 | 0.0497672375822 | 0.4 | RUNX2 CBFB | Abnormal pubic bone morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RUNX2 | CBFB | 0.996 | 0.172 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RUNX3 | CBFB | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RUNX1 | CBFB | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RUNX2 | RUNX1 | 0.99 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RUNX2 | RUNX3 | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FBXW12 | CBFB | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RUNX1 | FBXW12 | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RUNX2 | FBXW12 | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FBXW12 | RUNX3 | 0.983 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MSX1 | RUNX1 | 0.902 | bioplex3_WMM WMM_only | |
| RUNX1 | RUNX3 | 0.879 | bioplex3_WMM WMM_only | |
| MSX1 | CBFB | 0.703 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| RUNX2 | huMAP3_01783.1 huMAP3_11331.1 |
| RUNX1 | huMAP3_01783.1 huMAP3_11331.1 |
| MSX1 | huMAP3_01600.1 huMAP3_11331.1 huMAP3_11690.1 huMAP3_14435.1 |
| FBXW12 | huMAP3_01783.1 huMAP3_11331.1 |
| RUNX3 | huMAP3_01783.1 huMAP3_11331.1 |
| CBFB | huMAP3_01783.1 huMAP3_11331.1 |