hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11333.1
Complex Portal: CPX-12465
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C6orf15 | Uncharacterized protein C6orf15 (Protein STG) | 4 | UniProt NCBI |
| PDYN | Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynorphin B) (Dyn-B) (Dynorphin B(1-13)); Leumorphin (Dynorphin B-29)] | 5 | UniProt NCBI |
| TIMM13 | Mitochondrial import inner membrane translocase subunit Tim13 | 5 | UniProt NCBI |
| TIMM8A | Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein) | 5 | UniProt NCBI |
| TIMM8B | Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6452 | 1.36501667663e-05 | 0.4 | TIMM13 TIMM8A | TIMM8A-TIMM13 complex |
| GO:0042719 | 1.92180881975e-05 | 0.6 | TIMM13 TIMM8A TIMM8B | mitochondrial intermembrane space protein transporter complex |
| CORUM:7198 | 4.09448956317e-05 | 0.4 | TIMM13 TIMM8A | TIMM8A-TIMM13-TIMM23 complex |
| REAC:R-HSA-1268020 | 0.000106169184171 | 0.6 | TIMM13 TIMM8A TIMM8B | Mitochondrial protein import |
| GO:0045039 | 0.000211268761872 | 0.6 | TIMM13 TIMM8A TIMM8B | protein insertion into mitochondrial inner membrane |
| REAC:R-HSA-9609507 | 0.0012622367962 | 0.6 | TIMM13 TIMM8A TIMM8B | Protein localization |
| GO:0090151 | 0.00350285844735 | 0.6 | TIMM13 TIMM8A TIMM8B | establishment of protein localization to mitochondrial membrane |
| GO:0007007 | 0.0094606249379 | 0.6 | TIMM13 TIMM8A TIMM8B | inner mitochondrial membrane organization |
| GO:0005758 | 0.0310683011928 | 0.6 | TIMM13 TIMM8A TIMM8B | mitochondrial intermembrane space |
| GO:0031970 | 0.0417184596383 | 0.6 | TIMM13 TIMM8A TIMM8B | organelle envelope lumen |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TIMM13 | TIMM8B | 1.0 | 0.716 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt Malo fraction boldt_WMM |
| TIMM13 | TIMM8A | 0.999 | 0.944 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM |
| TIMM8A | TIMM8B | 0.996 | 0.148 |
mutually_exclusive (Q9Y5L4)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| PDYN | TIMM13 | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| C6orf15 | TIMM8A | 0.99 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| C6orf15 | TIMM8B | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| C6orf15 | TIMM13 | 0.985 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PDYN | TIMM8A | 0.97 |
mutually_exclusive (Q9Y5L4)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PDYN | TIMM8B | 0.969 |
mutually_exclusive (Q9Y5L4)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| C6orf15 | huMAP3_01289.1 huMAP3_11333.1 huMAP3_15060.1 |
| PDYN | huMAP3_01289.1 huMAP3_03396.1 huMAP3_11333.1 huMAP3_12806.1 huMAP3_15060.1 |
| TIMM13 | huMAP3_01289.1 huMAP3_11333.1 huMAP3_15060.1 |
| TIMM8A | huMAP3_01289.1 huMAP3_11333.1 huMAP3_15060.1 |
| TIMM8B | huMAP3_01289.1 huMAP3_11333.1 huMAP3_15060.1 |