hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11353.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GCLM | Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) | 5 | UniProt NCBI |
| GCLC | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) | 5 | UniProt NCBI |
| RCC2 | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7186 | 3.41752350426e-06 | 0.666666666667 | GCLM GCLC | Glutamate-cysteine ligase |
| REAC:R-HSA-5578999 | 6.81845708859e-06 | 0.666666666667 | GCLM GCLC | Defective GCLC causes HAGGSD |
| WP:WP3 | 0.000103023242897 | 0.666666666667 | GCLM GCLC | Transcriptional activation by NRF2 in response to phytochemicals |
| WP:WP100 | 0.000153947718176 | 0.666666666667 | GCLM GCLC | Glutathione metabolism |
| WP:WP4357 | 0.000261425039751 | 0.666666666667 | GCLM GCLC | NRF2 ARE regulation |
| WP:WP3612 | 0.000261425039751 | 0.666666666667 | GCLM GCLC | Photodynamic therapy induced NFE2L2 NRF2 survival signaling |
| WP:WP5113 | 0.000367738611184 | 0.666666666667 | GCLM GCLC | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway |
| REAC:R-HSA-174403 | 0.000374861161166 | 0.666666666667 | GCLM GCLC | Glutathione synthesis and recycling |
| KEGG:04216 | 0.000480177590636 | 0.666666666667 | GCLM GCLC | Ferroptosis |
| KEGG:00270 | 0.000788502734463 | 0.666666666667 | GCLM GCLC | Cysteine and methionine metabolism |
| REAC:R-HSA-9818027 | 0.000817692256233 | 0.666666666667 | GCLM GCLC | NFE2L2 regulating anti-oxidant/detoxification enzymes |
| REAC:R-HSA-5579029 | 0.000926675585137 | 0.666666666667 | GCLM GCLC | Metabolic disorders of biological oxidation enzymes |
| KEGG:00480 | 0.000933081380813 | 0.666666666667 | GCLM GCLC | Glutathione metabolism |
| WP:WP3940 | 0.00102095428698 | 0.666666666667 | GCLM GCLC | One carbon metabolism and related pathways |
| GO:0004357 | 0.00140460216025 | 0.666666666667 | GCLM GCLC | glutamate-cysteine ligase activity |
| GO:0017109 | 0.00140460216025 | 0.666666666667 | GCLM GCLC | glutamate-cysteine ligase complex |
| WP:WP2525 | 0.00167805708824 | 0.666666666667 | GCLM GCLC | Trans sulfuration one carbon metabolism and related pathways |
| WP:WP4313 | 0.00186764162171 | 0.666666666667 | GCLM GCLC | Ferroptosis |
| REAC:R-HSA-156590 | 0.0033773260227 | 0.666666666667 | GCLM GCLC | Glutathione conjugation |
| KEGG:01240 | 0.00676143238566 | 0.666666666667 | GCLM GCLC | Biosynthesis of cofactors |
| WP:WP2884 | 0.00700579973273 | 0.666666666667 | GCLM GCLC | NRF2 pathway |
| REAC:R-HSA-9759194 | 0.0204048321881 | 0.666666666667 | GCLM GCLC | Nuclear events mediated by NFE2L2 |
| REAC:R-HSA-156580 | 0.0214696523361 | 0.666666666667 | GCLM GCLC | Phase II - Conjugation of compounds |
| GO:0006750 | 0.0294899169624 | 0.666666666667 | GCLM GCLC | glutathione biosynthetic process |
| WP:WP2882 | 0.0351361093338 | 0.666666666667 | GCLM GCLC | Nuclear receptors meta pathway |
| REAC:R-HSA-9755511 | 0.0363497159339 | 0.666666666667 | GCLM GCLC | KEAP1-NFE2L2 pathway |
| GO:0019184 | 0.0393180950424 | 0.666666666667 | GCLM GCLC | nonribosomal peptide biosynthetic process |
| WP:WP4518 | 0.0496447587094 | 0.333333333333 | GCLC | Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GCLM | GCLC | 1.0 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| GCLM | RCC2 | 0.932 | 0.028 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| GCLC | RCC2 | 0.035 | 0.042 | bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes