hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11354.1
Complex Portal: CPX-22260
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DEPDC1 | DEP domain-containing protein 1A | 5 | UniProt NCBI |
| CSF1R | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) | 5 | UniProt NCBI |
| PDGFRB | Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3640 | 0.000173183276299 | 0.666666666667 | CSF1R PDGFRB | Imatinib and chronic myeloid leukemia |
| WP:WP4540 | 0.00374811209074 | 0.666666666667 | CSF1R PDGFRB | Hippo signaling regulation pathways |
| WP:WP4541 | 0.00514316015145 | 0.666666666667 | CSF1R PDGFRB | Hippo Merlin signaling dysregulation |
| KEGG:04015 | 0.010376143546 | 0.666666666667 | CSF1R PDGFRB | Rap1 signaling pathway |
| WP:WP4223 | 0.0120750625641 | 0.666666666667 | CSF1R PDGFRB | Ras signaling |
| KEGG:04014 | 0.0127453972967 | 0.666666666667 | CSF1R PDGFRB | Ras signaling pathway |
| KEGG:04010 | 0.0221986078054 | 0.666666666667 | CSF1R PDGFRB | MAPK signaling pathway |
| KEGG:04151 | 0.0307080825491 | 0.666666666667 | CSF1R PDGFRB | PI3K-Akt signaling pathway |
| HP:0002172 | 0.0340663843581 | 0.666666666667 | CSF1R PDGFRB | Postural instability |
| WP:WP3932 | 0.0343043102958 | 0.666666666667 | CSF1R PDGFRB | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP4172 | 0.0409328508823 | 0.666666666667 | CSF1R PDGFRB | PI3K Akt signaling pathway |
| CORUM:6413 | 0.0499402709677 | 0.333333333333 | PDGFRB | PDGFB-PDGFRB complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PDGFRB | CSF1R | 0.942 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DEPDC1 | PDGFRB | 0.895 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DEPDC1 | CSF1R | 0.113 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| DEPDC1 | huMAP3_04567.1 huMAP3_04775.1 huMAP3_05359.1 huMAP3_06891.1 huMAP3_09642.1 huMAP3_09966.1 huMAP3_09977.1 huMAP3_11354.1 huMAP3_13071.1 |
| CSF1R | huMAP3_11354.1 |
| PDGFRB | huMAP3_05000.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09311.1 huMAP3_11354.1 |