hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11357.1

Complex Portal: CPX-13233

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
COPB2	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)	5	UniProt NCBI
CYP4F3	Cytochrome P450 4F3 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYPIVF3) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase CYP4F3) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 2) (Leukotriene-B(4) omega-hydroxylase 2) (EC 1.14.14.94)	5	UniProt NCBI
COPG2	Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP)	5	UniProt NCBI
COPG1	Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)	5	UniProt NCBI
ARCN1	Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP)	5	UniProt NCBI
CD74	HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]	5	UniProt NCBI
COPZ2	Coatomer subunit zeta-2 (Zeta-2-coat protein) (Zeta-2 COP)	4	UniProt NCBI
COPZ1	Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP)	5	UniProt NCBI
KCNJ10	ATP-sensitive inward rectifier potassium channel 10 (ATP-dependent inwardly rectifying potassium channel Kir4.1) (Inward rectifier K(+) channel Kir1.2) (Potassium channel, inwardly rectifying subfamily J member 10)	5	UniProt NCBI
COPA	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]	5	UniProt NCBI
COPB1	Coatomer subunit beta (Beta-coat protein) (Beta-COP)	5	UniProt NCBI
KCNJ12	ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12)	5	UniProt NCBI
COPE	Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0030126	3.05349669742e-22	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	COPI vesicle coat
GO:0030663	1.03716537278e-20	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	COPI-coated vesicle membrane
GO:0030137	7.16056970181e-20	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	COPI-coated vesicle
GO:0030660	3.75470065178e-16	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Golgi-associated vesicle membrane
REAC:R-HSA-6811434	2.20066785993e-15	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	COPI-dependent Golgi-to-ER retrograde traffic
REAC:R-HSA-6807878	2.96426998974e-15	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	COPI-mediated anterograde transport
GO:0030120	3.80054213759e-15	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	vesicle coat
GO:0006891	1.30401399129e-14	0.615384615385	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA COPB1	intra-Golgi vesicle-mediated transport
GO:0005798	2.38700927565e-14	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Golgi-associated vesicle
REAC:R-HSA-8856688	3.73679453281e-14	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Golgi-to-ER retrograde transport
GO:0030662	1.0834114923e-13	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	coated vesicle membrane
REAC:R-HSA-199977	1.20437428087e-13	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	ER to Golgi Anterograde Transport
GO:0030117	2.15078500211e-13	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	membrane coat
GO:0048475	2.15078500211e-13	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	coated membrane
REAC:R-HSA-948021	6.58403793926e-13	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Transport to the Golgi and subsequent modification
REAC:R-HSA-6811442	1.89099467484e-12	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Intra-Golgi and retrograde Golgi-to-ER traffic
GO:0030135	7.68132011504e-12	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	coated vesicle
GO:0030133	2.6568747804e-11	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	transport vesicle
REAC:R-HSA-446203	6.15745116341e-11	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Asparagine N-linked glycosylation
GO:0000139	3.10023562103e-09	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	Golgi membrane
GO:0048193	7.35777454314e-09	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Golgi vesicle transport
GO:0005789	1.05610335767e-08	0.846153846154	COPZ2 COPG2 COPE COPB2 CYP4F3 COPZ1 COPG1 COPA CD74 ARCN1 COPB1	endoplasmic reticulum membrane
GO:0098827	1.25250620163e-08	0.846153846154	COPZ2 COPG2 COPE COPB2 CYP4F3 COPZ1 COPG1 COPA CD74 ARCN1 COPB1	endoplasmic reticulum subcompartment
GO:0042175	1.37308167147e-08	0.846153846154	COPZ2 COPG2 COPE COPB2 CYP4F3 COPZ1 COPG1 COPA CD74 ARCN1 COPB1	nuclear outer membrane-endoplasmic reticulum membrane network
REAC:R-HSA-199991	3.4934800239e-08	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Membrane Trafficking
REAC:R-HSA-5653656	5.66987906331e-08	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Vesicle-mediated transport
GO:0006890	9.90278250428e-08	0.461538461538	COPZ2 COPG2 COPB2 ARCN1 COPZ1 COPA	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0006888	1.54015249201e-07	0.538461538462	COPB1 COPB2 COPE ARCN1 COPG1 COPA COPG2	endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0031984	2.5505690792e-07	0.846153846154	COPZ2 COPG2 COPE COPB2 CYP4F3 COPZ1 COPG1 COPA CD74 ARCN1 COPB1	organelle subcompartment
GO:0030659	1.50469687255e-06	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	cytoplasmic vesicle membrane
GO:0012506	1.76071039887e-06	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	vesicle membrane
GO:0098796	1.15680585576e-05	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	membrane protein complex
GO:0005783	1.69838987719e-05	0.846153846154	COPZ2 COPG2 COPE COPB2 CYP4F3 COPZ1 COPG1 COPA CD74 ARCN1 COPB1	endoplasmic reticulum
REAC:R-HSA-597592	2.98907719811e-05	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Post-translational protein modification
GO:0046907	5.48243159446e-05	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	intracellular transport
GO:0005794	8.32683077374e-05	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	Golgi apparatus
REAC:R-HSA-392499	0.000501379658429	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	Metabolism of proteins
GO:0051649	0.000629021087222	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	establishment of localization in cell
GO:0098588	0.000943900091301	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	bounding membrane of organelle
GO:0006810	0.00112624997623	0.923076923077	COPZ2 COPG2 KCNJ12 COPB2 KCNJ10 COPZ1 COPG1 COPA CD74 COPE ARCN1 COPB1	transport
GO:0016192	0.00200337775669	0.692307692308	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA ARCN1 COPB1	vesicle-mediated transport
GO:0015031	0.00279550994299	0.615384615385	COPZ2 COPG2 COPB2 COPZ1 COPG1 COPA CD74 ARCN1	protein transport
GO:0051234	0.00329810686009	0.923076923077	COPZ2 COPG2 KCNJ12 COPB2 KCNJ10 COPZ1 COPG1 COPA CD74 COPE ARCN1 COPB1	establishment of localization
GO:0031410	0.00356320885352	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	cytoplasmic vesicle
GO:0097708	0.00362612809337	0.769230769231	COPZ2 COPG2 COPB2 COPE COPZ1 COPG1 COPA CD74 ARCN1 COPB1	intracellular vesicle
GO:0031090	0.00902823659397	0.846153846154	COPZ2 COPG2 COPE COPB2 CYP4F3 COPZ1 COPG1 COPA CD74 ARCN1 COPB1	organelle membrane
GO:0051179	0.0199727124555	0.923076923077	COPZ2 COPG2 KCNJ12 COPB2 KCNJ10 COPZ1 COPG1 COPA CD74 COPE ARCN1 COPB1	localization
GO:0045184	0.0224122970667	0.615384615385	COPZ2 COPG2 COPB2 COPZ1 COPG1 COPA CD74 ARCN1	establishment of protein localization
HPA:0180053	0.0346862806731	0.538461538462	COPB1 COPB2 COPE ARCN1 COPG1 COPA COPG2	epididymis; glandular cells[High]
GO:0071705	0.0387690228868	0.615384615385	COPZ2 COPG2 COPB2 COPZ1 COPG1 COPA CD74 ARCN1	nitrogen compound transport
REAC:R-HSA-1296059	0.0499595654642	0.153846153846	KCNJ12 KCNJ10	G protein gated Potassium channels
REAC:R-HSA-1296041	0.0499595654642	0.153846153846	KCNJ12 KCNJ10	Activation of G protein gated Potassium channels
REAC:R-HSA-997272	0.0499595654642	0.153846153846	KCNJ12 KCNJ10	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
COPB2	COPE	1.0	0.964
COPA	COPE	1.0	0.924
COPB1	COPE	1.0	0.962
COPB2	COPA	1.0	0.964	structurally_consistent (dimer)
COPG1	COPE	1.0	0.91	structurally_consistent (dimer)
COPB2	COPG1	1.0	0.962
COPG1	ARCN1	1.0	0.85	structurally_consistent (P53618)
ARCN1	COPB1	1.0	0.986	structurally_consistent (dimer)
COPG1	COPB1	1.0	0.99	structurally_consistent (dimer)
ARCN1	COPA	1.0	0.816
COPB2	ARCN1	1.0	0.972
COPA	COPB1	1.0	0.986	structurally_consistent (P35606) structurally_consistent (dimer)
COPG2	COPE	1.0	0.428
COPB2	COPB1	1.0	0.974	structurally_consistent (dimer)
COPG1	COPA	1.0	0.952
COPG2	COPG1	0.999	0.476	structurally_consistent (dimer)
ARCN1	COPE	0.999	0.88	structurally_consistent (dimer)
COPG2	COPB1	0.999	0.864	structurally_consistent (dimer)
COPG1	COPZ1	0.999	0.724	structurally_consistent (dimer)
COPG2	COPA	0.999	0.76	structurally_consistent (P53618)
COPG2	ARCN1	0.998	0.578
COPG2	COPZ1	0.998	0.464	structurally_consistent (P53618)
COPB2	COPG2	0.998	0.812
ARCN1	COPZ1	0.997	0.842
COPZ1	COPA	0.997	0.798
COPB2	COPZ1	0.996	0.916666666667
COPZ1	COPB1	0.996	0.912	structurally_consistent (dimer)
KCNJ12	KCNJ10	0.996		structurally_consistent (dimer)
COPZ1	COPE	0.996	0.882
COPG1	COPZ2	0.991	0.174	structurally_consistent (dimer)
COPG2	KCNJ10	0.988		structurally_consistent (dimer)
COPZ2	COPB1	0.987	0.332
COPZ2	COPA	0.984	0.332
COPB2	COPZ2	0.984	0.37
COPZ2	COPE	0.983	0.264	structurally_consistent (dimer)
ARCN1	COPZ2	0.98	0.316
COPG1	KCNJ10	0.974		structurally_consistent (Q9UBF2) structurally_consistent (dimer)
CD74	COPG1	0.936	0.172
COPB1	KCNJ10	0.923
CD74	COPG2	0.915	0.086
CD74	COPA	0.905	0.294
CYP4F3	CD74	0.902
COPA	KCNJ10	0.878
ARCN1	KCNJ10	0.828
CD74	ARCN1	0.825	0.176
CD74	COPB2	0.821	0.176
COPB2	KCNJ10	0.802
CD74	COPE	0.767	0.092
COPE	KCNJ10	0.594
CD74	COPB1	0.569	0.19
COPZ1	KCNJ10	0.555		mutually_exclusive (Q9Y678)
KCNJ12	COPG2	0.486
COPG2	COPZ2	0.127	0.142
KCNJ12	COPG1	0.096		mutually_exclusive (P78508)
KCNJ12	COPB2	0.096
KCNJ12	COPA	0.096
KCNJ12	COPB1	0.078
KCNJ12	COPE	0.062
KCNJ12	ARCN1	0.048
KCNJ12	COPZ1	0.035

Related Complexes

Genename	Complexes
COPB2	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
CYP4F3	huMAP3_03665.1 huMAP3_08221.1 huMAP3_11357.1 huMAP3_14691.1
COPG2	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
COPG1	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
ARCN1	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
CD74	huMAP3_04329.1 huMAP3_11357.1 huMAP3_14691.1
COPZ2	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
COPZ1	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
KCNJ10	huMAP3_08801.1 huMAP3_10156.1 huMAP3_11357.1 huMAP3_11837.1 huMAP3_12869.1
COPA	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
COPB1	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
KCNJ12	huMAP3_02988.1 huMAP3_03451.1 huMAP3_08801.1 huMAP3_11357.1 huMAP3_11358.1 huMAP3_12869.1 huMAP3_13438.1 huMAP3_14543.1 huMAP3_15147.1
COPE	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11357.1

Complex Portal: CPX-13233