hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11381.1
Complex Portal: CPX-20003
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STK38 | Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) | 5 | UniProt NCBI |
| MOB1B | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | 5 | UniProt NCBI |
| MOB1A | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | 5 | UniProt NCBI |
| STK38L | Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) | 5 | UniProt NCBI |
| LATS2 | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | 5 | UniProt NCBI |
| MOB2 | MOB kinase activator 2 (HCCA2) (Mob2 homolog) (Mps one binder kinase activator-like 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 5.15586089862e-06 | 0.5 | MOB1B MOB1A LATS2 | Hippo signaling pathway - multiple species |
| REAC:R-HSA-2028269 | 6.83169380613e-06 | 0.5 | MOB1B MOB1A LATS2 | Signaling by Hippo |
| WP:WP4542 | 1.00378310922e-05 | 0.5 | STK38L MOB1A LATS2 | Leukocyte intrinsic Hippo pathway functions |
| WP:WP5087 | 0.00042685807378 | 0.666666666667 | MOB1B LATS2 MOB1A STK38L | Pleural mesothelioma |
| KEGG:04390 | 0.000989019592829 | 0.5 | MOB1B MOB1A LATS2 | Hippo signaling pathway |
| WP:WP4537 | 0.00171766688832 | 0.333333333333 | STK38L LATS2 | Hippo YAP signaling |
| GO:0006468 | 0.00232878531203 | 1.0 | LATS2 MOB1B MOB2 STK38 STK38L MOB1A | protein phosphorylation |
| GO:0016310 | 0.00393304186908 | 1.0 | LATS2 MOB1B MOB2 STK38 STK38L MOB1A | phosphorylation |
| GO:0035329 | 0.0219369042126 | 0.5 | MOB1B MOB1A LATS2 | hippo signaling |
| GO:0001932 | 0.0376132764513 | 0.833333333333 | MOB2 MOB1B LATS2 STK38 MOB1A | regulation of protein phosphorylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| STK38L | MOB2 | 1.0 | 0.096 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| LATS2 | MOB1B | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK38L | MOB1B | 0.999 | 0.28 |
mutually_exclusive (Q9H8S9)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| STK38 | MOB2 | 0.999 | 0.304 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| STK38L | MOB1A | 0.999 | 0.16 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MOB1A | MOB1B | 0.99 | 0.672 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| STK38 | MOB1B | 0.97 | 0.124 |
mutually_exclusive (Q70IA6)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| STK38L | STK38 | 0.966 | 0.066 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| MOB2 | MOB1A | 0.868 | 0.056 |
mutually_exclusive (Q9Y2H1)
|
bioplex_WMM bioplex3_WMM WMM_only |
| MOB1A | LATS2 | 0.858 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| STK38L | LATS2 | 0.625 | bioplex_WMM bioplex3_WMM WMM_only | ||
| STK38 | MOB1A | 0.333 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only | |
| MOB2 | MOB1B | 0.197 | 0.096 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| STK38 | LATS2 | 0.011 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| MOB2 | LATS2 | 0.006 |
mutually_exclusive (Q7L9L4)
|
youn_WMM WMM_only |
Related Complexes