hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11389.1
Complex Portal: CPX-21949
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMAD3 | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | 5 | UniProt NCBI |
| SMAD2 | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | 5 | UniProt NCBI |
| ACO1 | Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) | 5 | UniProt NCBI |
| SMAD9 | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | 5 | UniProt NCBI |
| RNF168 | E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) | 5 | UniProt NCBI |
| GAS7 | Growth arrest-specific protein 7 (GAS-7) | 5 | UniProt NCBI |
| ZFYVE9 | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | 5 | UniProt NCBI |
| LDLRAD4 | Low-density lipoprotein receptor class A domain-containing protein 4 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1827 | 3.92798604902e-08 | 0.375 | ZFYVE9 SMAD3 SMAD2 | PML-SMAD2/3-SARA complex |
| WP:WP560 | 4.11262197767e-07 | 0.5 | ZFYVE9 SMAD9 SMAD3 SMAD2 | TGF beta receptor signaling |
| WP:WP4816 | 4.96305994219e-07 | 0.5 | ZFYVE9 SMAD9 SMAD3 SMAD2 | TGF beta receptor signaling in skeletal dysplasias |
| KEGG:04350 | 3.98597497177e-06 | 0.5 | ZFYVE9 SMAD9 SMAD3 SMAD2 | TGF-beta signaling pathway |
| WP:WP4331 | 4.83580446453e-05 | 0.375 | SMAD9 SMAD3 SMAD2 | Neovascularisation processes |
| CORUM:2834 | 7.17483486175e-05 | 0.25 | SMAD3 SMAD2 | SMAD4-SMAD2-SMAD3 complex |
| CORUM:2830 | 7.17483486175e-05 | 0.25 | SMAD3 SMAD2 | TIF1gamma-SMAD2-SMAD3 complex |
| REAC:R-HSA-3315487 | 0.000167311042734 | 0.25 | SMAD3 SMAD2 | SMAD2/3 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3304347 | 0.000167311042734 | 0.25 | SMAD3 SMAD2 | Loss of Function of SMAD4 in Cancer |
| REAC:R-HSA-3311021 | 0.000167311042734 | 0.25 | SMAD3 SMAD2 | SMAD4 MH2 Domain Mutants in Cancer |
| GO:0071141 | 0.0001882019462 | 0.375 | SMAD9 SMAD3 SMAD2 | SMAD protein complex |
| GO:0071144 | 0.0001882019462 | 0.375 | SMAD9 SMAD3 SMAD2 | heteromeric SMAD protein complex |
| GO:0007179 | 0.000281322020506 | 0.625 | ZFYVE9 SMAD9 SMAD3 LDLRAD4 SMAD2 | transforming growth factor beta receptor signaling pathway |
| REAC:R-HSA-3304356 | 0.000334530488176 | 0.25 | SMAD3 SMAD2 | SMAD2/3 Phosphorylation Motif Mutants in Cancer |
| REAC:R-HSA-3656532 | 0.000334530488176 | 0.25 | SMAD3 SMAD2 | TGFBR1 KD Mutants in Cancer |
| WP:WP4904 | 0.000501688733948 | 0.25 | LDLRAD4 SMAD2 | LDLRAD4 and what we know about it |
| GO:0071560 | 0.000546529050406 | 0.625 | ZFYVE9 SMAD9 SMAD3 LDLRAD4 SMAD2 | cellular response to transforming growth factor beta stimulus |
| REAC:R-HSA-3656534 | 0.000557398190654 | 0.25 | SMAD3 SMAD2 | Loss of Function of TGFBR1 in Cancer |
| REAC:R-HSA-3304349 | 0.000557398190654 | 0.25 | SMAD3 SMAD2 | Loss of Function of SMAD2/3 in Cancer |
| WP:WP5353 | 0.000625219299609 | 0.375 | SMAD9 SMAD3 SMAD2 | A network map of Macrophage stimulating protein MSP signaling |
| GO:0071559 | 0.00063230522663 | 0.625 | ZFYVE9 SMAD9 SMAD3 LDLRAD4 SMAD2 | response to transforming growth factor beta |
| GO:0046332 | 0.000668834683502 | 0.5 | LDLRAD4 SMAD9 SMAD3 SMAD2 | SMAD binding |
| GO:0060395 | 0.000828238133244 | 0.5 | LDLRAD4 SMAD9 SMAD3 SMAD2 | SMAD protein signal transduction |
| REAC:R-HSA-3304351 | 0.000835868410279 | 0.25 | SMAD3 SMAD2 | Signaling by TGF-beta Receptor Complex in Cancer |
| CORUM:2829 | 0.000859567015467 | 0.25 | SMAD3 SMAD2 | RSmad complex |
| KEGG:04550 | 0.00145234226842 | 0.375 | SMAD9 SMAD3 SMAD2 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP5382 | 0.00157457895347 | 0.25 | SMAD3 SMAD2 | TGF Smad signaling pathway |
| REAC:R-HSA-9796292 | 0.00200443712543 | 0.25 | SMAD3 SMAD2 | Formation of axial mesoderm |
| REAC:R-HSA-9823730 | 0.00200443712543 | 0.25 | SMAD3 SMAD2 | Formation of definitive endoderm |
| GO:0141091 | 0.00203933986446 | 0.625 | ZFYVE9 SMAD9 SMAD3 LDLRAD4 SMAD2 | transforming growth factor beta receptor superfamily signaling pathway |
| HP:0008419 | 0.00225842370351 | 0.25 | SMAD3 SMAD2 | Intervertebral disc degeneration |
| GO:0070411 | 0.00244160521127 | 0.375 | SMAD9 SMAD3 SMAD2 | I-SMAD binding |
| WP:WP3874 | 0.00250295506608 | 0.25 | SMAD3 SMAD2 | Canonical and non canonical TGF B signaling |
| WP:WP3859 | 0.00250295506608 | 0.25 | SMAD3 SMAD2 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition |
| REAC:R-HSA-1502540 | 0.00250486048439 | 0.25 | SMAD3 SMAD2 | Signaling by Activin |
| WP:WP366 | 0.00261051604069 | 0.375 | ZFYVE9 SMAD3 SMAD2 | TGF beta signaling pathway |
| GO:0007178 | 0.00265724086038 | 0.625 | ZFYVE9 SMAD9 SMAD3 LDLRAD4 SMAD2 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| REAC:R-HSA-9754189 | 0.00367178411278 | 0.25 | SMAD3 SMAD2 | Germ layer formation at gastrulation |
| WP:WP5103 | 0.00407177869695 | 0.25 | SMAD3 SMAD2 | Progeria associated lipodystrophy |
| GO:0070412 | 0.0043754188034 | 0.375 | LDLRAD4 SMAD3 SMAD2 | R-SMAD binding |
| REAC:R-HSA-9006936 | 0.00455165033631 | 0.375 | SMAD9 SMAD3 SMAD2 | Signaling by TGFB family members |
| WP:WP3668 | 0.00656300097601 | 0.25 | SMAD3 SMAD2 | Hypothesized pathways in pathogenesis of cardiovascular disease |
| REAC:R-HSA-9617828 | 0.00666866305696 | 0.25 | SMAD3 SMAD2 | FOXO-mediated transcription of cell cycle genes |
| HP:0100718 | 0.00812142628406 | 0.25 | SMAD3 SMAD2 | Uterine rupture |
| HP:0005086 | 0.00812142628406 | 0.25 | SMAD3 SMAD2 | Knee osteoarthritis |
| REAC:R-HSA-1181150 | 0.00849789009901 | 0.25 | SMAD3 SMAD2 | Signaling by NODAL |
| WP:WP2870 | 0.00897861635867 | 0.25 | SMAD3 SMAD2 | Extracellular vesicle mediated signaling in recipient cells |
| KEGG:04144 | 0.0101901500628 | 0.375 | ZFYVE9 SMAD3 SMAD2 | Endocytosis |
| WP:WP3850 | 0.0103268762936 | 0.25 | SMAD3 SMAD2 | Factors and pathways affecting insulin like growth factor IGF1 Akt signaling |
| KEGG:05321 | 0.0115899115219 | 0.25 | SMAD3 SMAD2 | Inflammatory bowel disease |
| REAC:R-HSA-2173788 | 0.0140328389809 | 0.25 | SMAD3 SMAD2 | Downregulation of TGF-beta receptor signaling |
| HP:0008843 | 0.014877056319 | 0.25 | SMAD3 SMAD2 | Hip osteoarthritis |
| HP:0005294 | 0.014877056319 | 0.25 | SMAD3 SMAD2 | Arterial dissection |
| REAC:R-HSA-9615017 | 0.0166306183768 | 0.25 | SMAD3 SMAD2 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| WP:WP4535 | 0.016652650636 | 0.25 | SMAD3 SMAD2 | Envelope proteins and their potential roles in EDMD physiopathology |
| WP:WP1971 | 0.0184665051061 | 0.25 | SMAD3 SMAD2 | Integrated cancer pathway |
| REAC:R-HSA-2173795 | 0.0224821270291 | 0.25 | SMAD3 SMAD2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| WP:WP4879 | 0.0255436500108 | 0.25 | SMAD3 SMAD2 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| WP:WP5144 | 0.0255436500108 | 0.25 | SMAD3 SMAD2 | NRP1 triggered signaling pathways in pancreatic cancer |
| KEGG:05212 | 0.032546331302 | 0.25 | SMAD3 SMAD2 | Pancreatic cancer |
| HP:0002170 | 0.0328794606484 | 0.375 | SMAD3 RNF168 SMAD2 | Intracranial hemorrhage |
| HP:0004959 | 0.0344311064357 | 0.25 | SMAD3 SMAD2 | Descending thoracic aorta aneurysm |
| HP:0012180 | 0.0344311064357 | 0.25 | SMAD3 SMAD2 | Cystic medial necrosis |
| HP:0032079 | 0.0344311064357 | 0.25 | SMAD3 SMAD2 | Medial degeneration |
| HP:0200146 | 0.0344311064357 | 0.25 | SMAD3 SMAD2 | Mucoid extracellular matrix accumulation |
| REAC:R-HSA-2173796 | 0.0348192347107 | 0.25 | SMAD3 SMAD2 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| REAC:R-HSA-9758941 | 0.0367988237757 | 0.25 | SMAD3 SMAD2 | Gastrulation |
| WP:WP5356 | 0.0376097283422 | 0.25 | SMAD3 SMAD2 | Affected pathways in Duchenne muscular dystrophy |
| KEGG:05210 | 0.0381752840247 | 0.25 | SMAD3 SMAD2 | Colorectal cancer |
| HP:0012763 | 0.0384712883781 | 0.25 | SMAD3 SMAD2 | Paroxysmal dyspnea |
| HP:0012432 | 0.0384712883781 | 0.25 | SMAD3 SMAD2 | Chronic fatigue |
| WP:WP5158 | 0.0402976114103 | 0.25 | SMAD3 SMAD2 | Urotensin II mediated signaling pathway |
| WP:WP2324 | 0.0416757621985 | 0.25 | SMAD3 SMAD2 | AGE RAGE pathway |
| GO:0071363 | 0.0427090045815 | 0.625 | ZFYVE9 SMAD9 SMAD3 LDLRAD4 SMAD2 | cellular response to growth factor stimulus |
| HP:0012499 | 0.0427341718023 | 0.25 | SMAD3 SMAD2 | Descending aortic dissection |
| REAC:R-HSA-2173789 | 0.0452582424141 | 0.25 | SMAD3 SMAD2 | TGF-beta receptor signaling activates SMADs |
| KEGG:04933 | 0.0474398326563 | 0.25 | SMAD3 SMAD2 | AGE-RAGE signaling pathway in diabetic complications |
| CORUM:3733 | 0.0499436884912 | 0.125 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3729 | 0.0499436884912 | 0.125 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3199 | 0.0499436884912 | 0.125 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3198 | 0.0499436884912 | 0.125 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3039 | 0.0499436884912 | 0.125 | SMAD2 | SMAD2-FAST1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ZFYVE9 | SMAD2 | 0.998 | 0.088 |
mutually_exclusive (Q99717)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ZFYVE9 | SMAD3 | 0.996 | 0.212 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| SMAD2 | SMAD3 | 0.993 | 0.29 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SMAD3 | SMAD9 | 0.989 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RNF168 | LDLRAD4 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SMAD2 | SMAD9 | 0.965 |
mutually_exclusive (P84022)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| ZFYVE9 | GAS7 | 0.902 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD2 | LDLRAD4 | 0.855 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SMAD3 | LDLRAD4 | 0.846 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SMAD9 | ACO1 | 0.835 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_HCT116 | ||
| SMAD2 | RNF168 | 0.502 | 0.19 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD3 | RNF168 | 0.502 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZFYVE9 | SMAD9 | 0.353 |
mutually_exclusive (P84022)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes