hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11389.1

Confidence: Medium

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Genename	Protein Name	Uniprot Annotation Score	Links
ACO1	Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)	5	UniProt NCBI
GAS7	Growth arrest-specific protein 7 (GAS-7)	5	UniProt NCBI
LDLRAD4	Low-density lipoprotein receptor class A domain-containing protein 4	5	UniProt NCBI
RNF168	E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)	5	UniProt NCBI
SMAD2	Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)	5	UniProt NCBI
SMAD3	Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)	5	UniProt NCBI
SMAD9	Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9)	5	UniProt NCBI
ZFYVE9	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)	5	UniProt NCBI

Showing 1 to 8 of 8 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1827	3.92798604902e-08	0.375	ZFYVE9 SMAD3 SMAD2	PML-SMAD2/3-SARA complex
WP:WP560	4.11262197767e-07	0.5	SMAD9 SMAD3 ZFYVE9 SMAD2	TGF beta receptor signaling
WP:WP4816	4.96305994219e-07	0.5	SMAD9 SMAD3 ZFYVE9 SMAD2	TGF beta receptor signaling in skeletal dysplasias
KEGG:04350	3.98597497177e-06	0.5	SMAD9 SMAD3 ZFYVE9 SMAD2	TGF-beta signaling pathway
WP:WP4331	4.83580446453e-05	0.375	SMAD9 SMAD3 SMAD2	Neovascularisation processes
CORUM:2834	7.17483486175e-05	0.25	SMAD3 SMAD2	SMAD4-SMAD2-SMAD3 complex
CORUM:2830	7.17483486175e-05	0.25	SMAD3 SMAD2	TIF1gamma-SMAD2-SMAD3 complex
REAC:R-HSA-3315487	0.000167311042734	0.25	SMAD3 SMAD2	SMAD2/3 MH2 Domain Mutants in Cancer
REAC:R-HSA-3304347	0.000167311042734	0.25	SMAD3 SMAD2	Loss of Function of SMAD4 in Cancer
REAC:R-HSA-3311021	0.000167311042734	0.25	SMAD3 SMAD2	SMAD4 MH2 Domain Mutants in Cancer

Showing 1 to 10 of 82 entries

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Protein 1	Protein 2	Score	ProteomeHD	Evidence
ZFYVE9	SMAD2	0.998	0.088	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
ZFYVE9	SMAD3	0.996	0.212	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
SMAD2	SMAD3	0.993	0.29	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SMAD3	SMAD9	0.989		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
RNF168	LDLRAD4	0.972		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SMAD2	SMAD9	0.965		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
ZFYVE9	GAS7	0.902	0.044	bioplex_WMM bioplex3_WMM WMM_only
SMAD2	LDLRAD4	0.855		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SMAD3	LDLRAD4	0.846		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SMAD9	ACO1	0.835		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_HCT116

Showing 1 to 10 of 13 entries

Related Complexes

Genename	Complexes
SMAD3	huMAP3_00500.1 huMAP3_00785.1 huMAP3_05180.1 huMAP3_09080.1 huMAP3_11389.1 huMAP3_13623.1 huMAP3_14587.1
SMAD2	huMAP3_00500.1 huMAP3_00785.1 huMAP3_05180.1 huMAP3_09080.1 huMAP3_11389.1 huMAP3_12636.1 huMAP3_13623.1 huMAP3_14587.1
ACO1	huMAP3_05161.1 huMAP3_10716.1 huMAP3_11389.1 huMAP3_12414.1 huMAP3_13623.1 huMAP3_14587.1
SMAD9	huMAP3_00785.1 huMAP3_02949.1 huMAP3_05180.1 huMAP3_09080.1 huMAP3_11389.1 huMAP3_13623.1 huMAP3_14587.1
RNF168	huMAP3_03094.1 huMAP3_10060.1 huMAP3_11389.1 huMAP3_11781.1
GAS7	huMAP3_03325.1 huMAP3_08945.1 huMAP3_10301.1 huMAP3_11389.1 huMAP3_13447.1 huMAP3_13623.1 huMAP3_14587.1 huMAP3_15340.1
ZFYVE9	huMAP3_00020.1 huMAP3_00500.1 huMAP3_05180.1 huMAP3_06304.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09080.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_11389.1 huMAP3_13623.1 huMAP3_14504.1 huMAP3_14587.1
LDLRAD4	huMAP3_03094.1 huMAP3_06467.1 huMAP3_06903.1 huMAP3_10060.1 huMAP3_11389.1 huMAP3_11781.1