hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11438.1
Complex Portal: CPX-16002
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HS3ST1 | Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1) | 5 | UniProt NCBI |
| BMP4 | Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) | 5 | UniProt NCBI |
| VGF | Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] | 5 | UniProt NCBI |
| EDDM3A | Epididymal secretory protein E3-alpha (Human epididymis-specific protein 3-alpha) (HE3-alpha) | 3 | UniProt NCBI |
| VIP | VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] | 5 | UniProt NCBI |
| IL20 | Interleukin-20 (IL-20) (Cytokine Zcyto10) | 5 | UniProt NCBI |
| TWSG1 | Twisted gastrulation protein homolog 1 | 5 | UniProt NCBI |
| PMCH | Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)] | 4 | UniProt NCBI |
| CORT | Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17] | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04080 | 0.00362594816438 | 0.428571428571 | CORT VGF VIP | Neuroactive ligand-receptor interaction |
| CORUM:1970 | 0.0499958217778 | 0.142857142857 | TWSG1 | BMP4-TWSG1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VGF | EDDM3A | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| VGF | PMCH | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| VIP | VGF | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| IL20 | VGF | 0.983 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BMP4 | HS3ST1 | 0.983 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TWSG1 | BMP4 | 0.979 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HS3ST1 | CORT | 0.955 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BMP4 | PMCH | 0.939 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BMP4 | VIP | 0.939 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BMP4 | CORT | 0.932 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BMP4 | IL20 | 0.932 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BMP4 | EDDM3A | 0.932 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EDDM3A | HS3ST1 | 0.914 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IL20 | HS3ST1 | 0.813 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BMP4 | VGF | 0.298 | bioplex3_WMM WMM_only | ||
| VGF | HS3ST1 | 0.298 |
mutually_exclusive (Q9NYY1)
|
bioplex3_WMM WMM_only | |
| TWSG1 | HS3ST1 | 0.042 | bioplex3_WMM WMM_only |
Related Complexes