hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11445.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BECN1 | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] | 5 | UniProt NCBI |
| UVRAG | UV radiation resistance-associated gene protein (p63) | 5 | UniProt NCBI |
| RUBCN | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | 5 | UniProt NCBI |
| PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | 5 | UniProt NCBI |
| RUBCNL | Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6472 | 1.12081835382e-08 | 0.6 | PIK3C3 BECN1 UVRAG | Bcl-2-Beclin1-UVRAG-PI(3)KC3 complex |
| GO:0097352 | 1.71703288855e-08 | 1.0 | PIK3C3 BECN1 RUBCNL RUBCN UVRAG | autophagosome maturation |
| REAC:R-HSA-9679504 | 5.14505990951e-07 | 0.6 | PIK3C3 BECN1 UVRAG | Translation of Replicase and Assembly of the Replication Transcription Complex |
| REAC:R-HSA-9694676 | 6.85937538545e-07 | 0.6 | PIK3C3 BECN1 UVRAG | Translation of Replicase and Assembly of the Replication Transcription Complex |
| KEGG:04140 | 3.00693972585e-06 | 0.8 | PIK3C3 BECN1 RUBCN UVRAG | Autophagy - animal |
| WP:WP4923 | 3.94574948313e-06 | 0.6 | PIK3C3 BECN1 UVRAG | Autophagy |
| REAC:R-HSA-9772572 | 1.69745830215e-05 | 0.6 | PIK3C3 BECN1 UVRAG | Early SARS-CoV-2 Infection Events |
| GO:0032984 | 2.06169322324e-05 | 1.0 | PIK3C3 BECN1 RUBCNL RUBCN UVRAG | protein-containing complex disassembly |
| GO:0035032 | 3.362820138e-05 | 0.6 | PIK3C3 BECN1 UVRAG | phosphatidylinositol 3-kinase complex, class III |
| GO:0016236 | 0.000109670539315 | 1.0 | PIK3C3 BECN1 RUBCNL RUBCN UVRAG | macroautophagy |
| GO:0036092 | 0.000115261178119 | 0.6 | PIK3C3 BECN1 UVRAG | phosphatidylinositol-3-phosphate biosynthetic process |
| GO:0005776 | 0.000168126820122 | 0.8 | PIK3C3 BECN1 RUBCNL UVRAG | autophagosome |
| GO:0022411 | 0.000807544779987 | 1.0 | PIK3C3 BECN1 RUBCNL RUBCN UVRAG | cellular component disassembly |
| WP:WP4863 | 0.00089796435942 | 0.4 | BECN1 PIK3C3 | Host pathogen interaction of human coronaviruses autophagy |
| REAC:R-HSA-1632852 | 0.00100303062327 | 0.6 | PIK3C3 BECN1 UVRAG | Macroautophagy |
| REAC:R-HSA-9678108 | 0.00115380230305 | 0.6 | PIK3C3 BECN1 UVRAG | SARS-CoV-1 Infection |
| GO:0061919 | 0.00130936938487 | 1.0 | PIK3C3 BECN1 RUBCNL RUBCN UVRAG | process utilizing autophagic mechanism |
| GO:0006914 | 0.00130936938487 | 1.0 | PIK3C3 BECN1 RUBCNL RUBCN UVRAG | autophagy |
| WP:WP2509 | 0.00135500760343 | 0.4 | BECN1 UVRAG | Nanoparticle triggered autophagic cell death |
| REAC:R-HSA-9612973 | 0.00140702215103 | 0.6 | PIK3C3 BECN1 UVRAG | Autophagy |
| GO:0016241 | 0.00167734490804 | 0.8 | PIK3C3 BECN1 RUBCN UVRAG | regulation of macroautophagy |
| KEGG:04136 | 0.00196978543336 | 0.4 | BECN1 PIK3C3 | Autophagy - other |
| GO:0005942 | 0.00220577099344 | 0.6 | PIK3C3 BECN1 UVRAG | phosphatidylinositol 3-kinase complex |
| REAC:R-HSA-9705683 | 0.00333687251766 | 0.6 | PIK3C3 BECN1 UVRAG | SARS-CoV-2-host interactions |
| WP:WP4577 | 0.00456408083355 | 0.4 | BECN1 PIK3C3 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| REAC:R-HSA-983170 | 0.00531742996423 | 0.4 | BECN1 PIK3C3 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-9694516 | 0.0101788028745 | 0.6 | PIK3C3 BECN1 UVRAG | SARS-CoV-2 Infection |
| WP:WP5205 | 0.0132783799217 | 0.4 | BECN1 PIK3C3 | Clock controlled autophagy in bone metabolism |
| GO:0034272 | 0.0140440992017 | 0.4 | BECN1 PIK3C3 | phosphatidylinositol 3-kinase complex, class III, type II |
| GO:0034271 | 0.0140440992017 | 0.4 | BECN1 PIK3C3 | phosphatidylinositol 3-kinase complex, class III, type I |
| GO:0046854 | 0.0155155487472 | 0.6 | PIK3C3 BECN1 UVRAG | phosphatidylinositol phosphate biosynthetic process |
| REAC:R-HSA-9679506 | 0.0263889851162 | 0.6 | PIK3C3 BECN1 UVRAG | SARS-CoV Infections |
| KEGG:04371 | 0.0273394134018 | 0.4 | BECN1 PIK3C3 | Apelin signaling pathway |
| KEGG:05017 | 0.0346393491085 | 0.4 | BECN1 PIK3C3 | Spinocerebellar ataxia |
| GO:0010506 | 0.0389526852651 | 0.8 | PIK3C3 BECN1 RUBCN UVRAG | regulation of autophagy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BECN1 | PIK3C3 | 0.999 | 0.138 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| BECN1 | UVRAG | 0.997 | 0.246 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PIK3C3 | RUBCNL | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UVRAG | RUBCNL | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UVRAG | RUBCN | 0.995 | 0.176 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only |
| BECN1 | RUBCN | 0.994 | 0.154 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () |
| BECN1 | RUBCNL | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RUBCN | PIK3C3 | 0.992 | 0.076 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only |
| UVRAG | PIK3C3 | 0.979 | 0.152 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes