hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11453.1
Confidence: Medium  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
PUF60 | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | 5 | UniProt   NCBI |
PRPF38B | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | 3 | UniProt   NCBI |
NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) | 5 | UniProt   NCBI |
JMJD6 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | 5 | UniProt   NCBI |
RBM26 | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | 5 | UniProt   NCBI |
KHSRP | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | 5 | UniProt   NCBI |
CPSF6 | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | 5 | UniProt   NCBI |
CWC25 | Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25) | 5 | UniProt   NCBI |
PHRF1 | PHD and RING finger domain-containing protein 1 | 4 | UniProt   NCBI |
RP9 | Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) | 5 | UniProt   NCBI |
KHDRBS3 | KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein T-Star) (Sam68-like mammalian protein 2) (SLM-2) (Sam68-like phosphotyrosine protein) | 5 | UniProt   NCBI |
RBM25 | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | 5 | UniProt   NCBI |
DDX41 | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | 5 | UniProt   NCBI |
SCAF4 | SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) | 5 | UniProt   NCBI |
PRPF38A | Pre-mRNA-splicing factor 38A | 5 | UniProt   NCBI |
SFSWAP | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | 4 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  GO:0006397 | 1.53789099491e-10 | 0.6875 | JMJD6 RBM25 KHDRBS3 DDX41 KHSRP CWC25 CPSF6 PUF60 PRPF38A SFSWAP NUDT21 | mRNA processing |
  GO:0008380 | 3.00896231108e-08 | 0.625 | RP9 RBM25 JMJD6 KHDRBS3 DDX41 CWC25 PRPF38A PUF60 SFSWAP KHSRP | RNA splicing |
  GO:0006396 | 3.00942600786e-08 | 0.75 | JMJD6 RBM25 RP9 KHDRBS3 DDX41 KHSRP CWC25 CPSF6 PUF60 PRPF38A SFSWAP NUDT21 | RNA processing |
  GO:0016071 | 3.87296890857e-08 | 0.6875 | JMJD6 RBM25 KHDRBS3 DDX41 KHSRP CWC25 CPSF6 PUF60 PRPF38A SFSWAP NUDT21 | mRNA metabolic process |
  GO:0000375 | 1.12138222381e-07 | 0.5625 | JMJD6 RBM25 KHDRBS3 DDX41 CWC25 PRPF38A PUF60 SFSWAP KHSRP | RNA splicing, via transesterification reactions |
  GO:0003723 | 1.15408542638e-06 | 0.8125 | JMJD6 RBM25 RP9 KHDRBS3 DDX41 NUDT21 CPSF6 SCAF4 PRPF38B PUF60 RBM26 PRPF38A KHSRP | RNA binding |
  GO:0000377 | 6.15089463466e-06 | 0.5 | JMJD6 RBM25 KHDRBS3 DDX41 CWC25 PRPF38A PUF60 SFSWAP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
  GO:0000398 | 6.15089463466e-06 | 0.5 | JMJD6 RBM25 KHDRBS3 DDX41 CWC25 PRPF38A PUF60 SFSWAP | mRNA splicing, via spliceosome |
  KEGG:03040 | 1.01466399686e-05 | 0.3125 | PUF60 RBM25 PRPF38B PRPF38A RP9 | Spliceosome |
  CORUM:351 | 1.22924158043e-05 | 0.3125 | PUF60 DDX41 RBM25 NUDT21 CPSF6 | Spliceosome |
  REAC:R-HSA-72203 | 8.22190933825e-05 | 0.375 | RBM25 DDX41 CWC25 PRPF38A PUF60 NUDT21 | Processing of Capped Intron-Containing Pre-mRNA |
  CORUM:1769 | 0.000153131458895 | 0.125 | CPSF6 NUDT21 | CPSF6-ITCH-NUDT21-POLR2A complex |
  CORUM:1767 | 0.000306067313039 | 0.125 | CPSF6 NUDT21 | CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex |
  CORUM:1768 | 0.000509786398016 | 0.125 | CPSF6 NUDT21 | CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex |
  REAC:R-HSA-72163 | 0.000528608390009 | 0.3125 | PUF60 DDX41 PRPF38A RBM25 CWC25 | mRNA Splicing - Major Pathway |
  REAC:R-HSA-72172 | 0.00062558307886 | 0.3125 | PUF60 DDX41 PRPF38A RBM25 CWC25 | mRNA Splicing |
  HPA:0301361 | 0.000652867068076 | 0.5 | RBM25 DDX41 SCAF4 CWC25 PRPF38B CPSF6 PUF60 KHSRP | lung; alveolar cells type I[>=Low] |
  REAC:R-HSA-8953854 | 0.00110168018053 | 0.4375 | RBM25 DDX41 KHSRP CWC25 PRPF38A PUF60 NUDT21 | Metabolism of RNA |
  GO:0048024 | 0.00115540580919 | 0.3125 | PUF60 SFSWAP RBM25 KHDRBS3 JMJD6 | regulation of mRNA splicing, via spliceosome |
  HPA:0090192 | 0.00121960251155 | 0.6875 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 RBM26 PUF60 SFSWAP KHSRP | cerebellum; cells in molecular layer[>=Medium] |
  HPA:0010012 | 0.00138546908188 | 0.625 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CPSF6 RBM26 PUF60 SFSWAP KHSRP | adipose tissue; adipocytes[>=Medium] |
  HPA:0570763 | 0.00196958750074 | 0.4375 | JMJD6 KHDRBS3 SCAF4 CWC25 CPSF6 PUF60 KHSRP | testis; pachytene spermatocytes[High] |
  HPA:0301362 | 0.00213351669665 | 0.4375 | RBM25 DDX41 SCAF4 CWC25 PRPF38B CPSF6 KHSRP | lung; alveolar cells type I[>=Medium] |
  HPA:0270352 | 0.00297766638632 | 0.6875 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 RBM26 PUF60 SFSWAP KHSRP | kidney; cells in glomeruli[>=Medium] |
  HPA:0570782 | 0.00333282481148 | 0.5 | JMJD6 RBM25 KHDRBS3 SCAF4 CWC25 CPSF6 PUF60 KHSRP | testis; preleptotene spermatocytes[>=Medium] |
  HPA:0570813 | 0.00339169439426 | 0.5 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 KHSRP | testis; spermatogonia cells[High] |
  GO:0050684 | 0.00356635821569 | 0.3125 | PUF60 SFSWAP RBM25 KHDRBS3 JMJD6 | regulation of mRNA processing |
  CORUM:1141 | 0.00395606553462 | 0.125 | CPSF6 NUDT21 | CF IIAm complex (Cleavage factor IIAm complex) |
  GO:0003676 | 0.00598077660945 | 0.8125 | JMJD6 RBM25 RP9 KHDRBS3 DDX41 NUDT21 CPSF6 SCAF4 PRPF38B PUF60 RBM26 PRPF38A KHSRP | nucleic acid binding |
  GO:1903311 | 0.00627116360803 | 0.375 | JMJD6 RBM25 KHDRBS3 SFSWAP PUF60 KHSRP | regulation of mRNA metabolic process |
  HPA:0600432 | 0.0068723277402 | 0.75 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 PRPF38B RBM26 PUF60 SFSWAP KHSRP | tonsil; germinal center cells[>=Medium] |
  HPA:0301371 | 0.00849779343155 | 0.5 | RBM25 DDX41 SCAF4 CWC25 PRPF38B CPSF6 PUF60 KHSRP | lung; alveolar cells type II[>=Low] |
  HPA:0380513 | 0.0152316698394 | 0.4375 | JMJD6 RBM25 SCAF4 CWC25 SFSWAP CPSF6 KHSRP | placenta; decidual cells[High] |
  HPA:0570792 | 0.0152738730621 | 0.5 | JMJD6 RBM25 KHDRBS3 SCAF4 CWC25 CPSF6 PUF60 KHSRP | testis; round or early spermatids[>=Medium] |
  HPA:0301372 | 0.0184302684774 | 0.4375 | RBM25 DDX41 SCAF4 CWC25 PRPF38B CPSF6 KHSRP | lung; alveolar cells type II[>=Medium] |
  HPA:0570781 | 0.0190038550956 | 0.5 | JMJD6 RBM25 KHDRBS3 SCAF4 CWC25 CPSF6 PUF60 KHSRP | testis; preleptotene spermatocytes[>=Low] |
  HPA:0570733 | 0.0196944530151 | 0.5 | JMJD6 DDX41 SCAF4 CPSF6 RBM26 PUF60 SFSWAP KHSRP | testis; Leydig cells[High] |
  HPA:0570802 | 0.0235745459407 | 0.5 | JMJD6 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 PUF60 KHSRP | testis; sertoli cells[>=Medium] |
  HPA:0570812 | 0.0253359094797 | 0.5625 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 PUF60 KHSRP | testis; spermatogonia cells[>=Medium] |
  GO:0043484 | 0.025809744143 | 0.3125 | PUF60 SFSWAP RBM25 KHDRBS3 JMJD6 | regulation of RNA splicing |
  HPA:0490692 | 0.026110767526 | 0.625 | JMJD6 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 RBM26 PUF60 SFSWAP KHSRP | smooth muscle; smooth muscle cells[>=Medium] |
  HPA:0460643 | 0.0264644798762 | 0.3125 | RBM26 CWC25 SCAF4 RBM25 CPSF6 | skin 1; Langerhans[High] |
  HPA:0100202 | 0.0287349948778 | 0.5625 | RBM25 DDX41 SCAF4 CWC25 RBM26 CPSF6 PUF60 SFSWAP KHSRP | cerebral cortex; endothelial cells[>=Medium] |
  HPA:0570801 | 0.0293551053322 | 0.5625 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 PUF60 KHSRP | testis; sertoli cells[>=Low] |
  HPA:0380523 | 0.0363927933192 | 0.5 | JMJD6 RBM25 SCAF4 CWC25 RBM26 CPSF6 SFSWAP KHSRP | placenta; trophoblastic cells[High] |
  HPA:0010011 | 0.0365160006986 | 0.6875 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 RBM26 PUF60 SFSWAP KHSRP | adipose tissue; adipocytes[>=Low] |
  HPA:0010000 | 0.0365160006986 | 0.6875 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 RBM26 PUF60 SFSWAP KHSRP | adipose tissue |
  HPA:0340461 | 0.0413953240098 | 0.6875 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 RBM26 PUF60 SFSWAP KHSRP | ovary; ovarian stroma cells[>=Low] |
  HPA:0420052 | 0.0418913597614 | 0.75 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 PRPF38B RBM26 PUF60 SFSWAP KHSRP | salivary gland; glandular cells[>=Medium] |
  HPA:0630052 | 0.0422803154684 | 0.6875 | JMJD6 RBM25 KHDRBS3 DDX41 SCAF4 CWC25 CPSF6 RBM26 PUF60 SFSWAP KHSRP | cervix; glandular cells[>=Medium] |
  GO:0016070 | 0.0423326252853 | 0.8125 | JMJD6 RBM25 RP9 KHDRBS3 DDX41 KHSRP CWC25 SCAF4 CPSF6 PUF60 PRPF38A SFSWAP NUDT21 | RNA metabolic process |
  HPA:0050012 | 0.0499980704384 | 0.4375 | JMJD6 DDX41 CPSF6 RBM26 PUF60 SFSWAP KHSRP | breast; adipocytes[>=Medium] |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD |
---|---|---|---|
 NUDT21 |  CPSF6 | 1.0 | 0.892           |
 JMJD6 |  RBM25 | 0.999 | 0.122           |
 JMJD6 |  SFSWAP | 0.998 | 0.054           |
 JMJD6 |  PHRF1 | 0.998 | 0.05           |
 JMJD6 |  PRPF38A | 0.996 | 0.088           |
 PUF60 |  JMJD6 | 0.993 | 0.126           |
 NUDT21 |  KHSRP | 0.974 | 0.786           |
 CWC25 |  DDX41 | 0.973 | 0.14           |
 JMJD6 |  CPSF6 | 0.969 | 0.172           |
 JMJD6 |  PRPF38B | 0.968 | 0.05           |
 PUF60 |  RBM25 | 0.963 | 0.694           |
 DDX41 |  PRPF38B | 0.919 | 0.12           |
 RP9 |  DDX41 | 0.909 | 0.084           |
 JMJD6 |  SCAF4 | 0.894 | 0.032           |
 JMJD6 |  NUDT21 | 0.886 | 0.18           |
 JMJD6 |  RBM26 | 0.867 | 0.096           |
 KHDRBS3 |  PRPF38A | 0.861 | 0.094           |
 CPSF6 |  RBM26 | 0.859 | 0.488           |
 RBM25 |  SFSWAP | 0.857 | 0.206           |
 JMJD6 |  RP9 | 0.835 | 0.06           |
 CWC25 |  RP9 | 0.834 | 0.15           |
 SCAF4 |  RBM26 | 0.832 | 0.228           |
 RP9 |  PRPF38A | 0.831 | 0.106           |
 RBM25 |  DDX41 | 0.829 | 0.468           |
 KHDRBS3 |  RBM26 | 0.817 | 0.09           |
 CPSF6 |  KHSRP | 0.812 | 0.696           |
 PHRF1 |  PRPF38A | 0.806 | 0.104           |
 KHDRBS3 |  DDX41 | 0.792 | 0.056           |
 CPSF6 |  RP9 | 0.789 | 0.118           |
 RP9 |  PRPF38B | 0.788 | 0.076           |
 KHDRBS3 |  SFSWAP | 0.781 | 0.034           |
 KHDRBS3 |  PRPF38B | 0.762 | 0.068           |
 PHRF1 |  RBM25 | 0.758 | 0.24           |
 RBM25 |  RBM26 | 0.749 | 0.566           |
 KHDRBS3 |  RP9 | 0.746 | 0.08           |
 JMJD6 |  DDX41 | 0.71 | 0.092           |
 RBM25 |  KHDRBS3 | 0.674 | 0.106           |
 RP9 |  SFSWAP | 0.613 | 0.1           |
 CWC25 |  PRPF38A | 0.566 | 0.18           |
 PHRF1 |  DDX41 | 0.565 | 0.108           |
 PHRF1 |  SFSWAP | 0.564 | 0.124           |
 RBM25 |  RP9 | 0.562 | 0.182           |
 RP9 |  RBM26 | 0.506 | 0.09           |
 PRPF38B |  SCAF4 | 0.492 | 0.294           |
 CWC25 |  SFSWAP | 0.481 | 0.202           |
 CWC25 |  SCAF4 | 0.477 | 0.123333333333           |
 CWC25 |  PRPF38B | 0.458 | 0.274           |
 KHDRBS3 |  SCAF4 | 0.453 | 0.062           |
 PRPF38A |  PRPF38B | 0.445 | 0.342           |
 CPSF6 |  KHDRBS3 | 0.439 | 0.14           |
 DDX41 |  RBM26 | 0.432 | 0.274           |
 PRPF38A |  DDX41 | 0.411 | 0.478           |
 CPSF6 |  SFSWAP | 0.408 | 0.156           |
 RBM25 |  NUDT21 | 0.379 | 0.612           |
 CPSF6 |  DDX41 | 0.366 | 0.236           |
 KHDRBS3 |  CWC25 | 0.364 | 0.04           |
 DDX41 |  SFSWAP | 0.358 | 0.128           |
 PRPF38B |  SFSWAP | 0.352 | 0.088           |
 SFSWAP |  RBM26 | 0.348 | 0.218           |
 NUDT21 |  KHDRBS3 | 0.339 | 0.174           |
 CWC25 |  RBM26 | 0.328 | 0.354           |
 SCAF4 |  SFSWAP | 0.328 | 0.178           |
 CPSF6 |  CWC25 | 0.325 | 0.4           |
 RBM25 |  PRPF38B | 0.323 | 0.238           |
 RBM25 |  CPSF6 | 0.306 | 0.75           |
 PHRF1 |  PRPF38B | 0.3 | 0.158           |
 RP9 |  SCAF4 | 0.288 | 0.066           |
 PHRF1 |  SCAF4 | 0.272 | 0.234           |
 PRPF38B |  RBM26 | 0.259 | 0.102           |
 PHRF1 |  RBM26 | 0.228 | 0.118           |
 PRPF38A |  SFSWAP | 0.22 | 0.194           |
 DDX41 |  SCAF4 | 0.215 | 0.108           |
 RBM25 |  KHSRP | 0.189 | 0.582           |
 RBM25 |  CWC25 | 0.188 | 0.358           |
 CPSF6 |  SCAF4 | 0.162 | 0.25           |
 PRPF38A |  RBM26 | 0.161 | 0.39           |
 PUF60 |  PHRF1 | 0.154 | 0.492           |
 PHRF1 |  CPSF6 | 0.143 | 0.188           |
 RBM25 |  PRPF38A | 0.135 | 0.466           |
 CPSF6 |  PRPF38A | 0.132 | 0.358           |
 PUF60 |  CPSF6 | 0.118 | 0.64           |
 PUF60 |  PRPF38A | 0.117 | 0.564           |
 RBM25 |  SCAF4 | 0.116 | 0.572           |
 NUDT21 |  RP9 | 0.092 | 0.112           |
 PHRF1 |  NUDT21 | 0.09 | 0.228           |
 PUF60 |  SFSWAP | 0.086 | 0.193333333333           |
 PUF60 |  RBM26 | 0.086 | 0.402           |
 PUF60 |  SCAF4 | 0.079 | 0.248           |
 NUDT21 |  SFSWAP | 0.075 | 0.142           |
 KHSRP |  RBM26 | 0.074 | 0.428           |
 PRPF38A |  SCAF4 | 0.074 | 0.146           |
 NUDT21 |  RBM26 | 0.064 | 0.218           |
 NUDT21 |  PRPF38A | 0.064 | 0.392           |
 NUDT21 |  SCAF4 | 0.046 | 0.344           |
 PUF60 |  PRPF38B | 0.04 | 0.128           |
 KHDRBS3 |  KHSRP | 0.04 | 0.09           |
 NUDT21 |  PRPF38B | 0.033 | 0.124           |
 RP9 |  KHSRP | 0.029 | 0.102           |
 CPSF6 |  PRPF38B | 0.025 | 0.206           |
 NUDT21 |  DDX41 | 0.023 | 0.232666666667           |
 PHRF1 |  KHSRP | 0.021 | 0.318           |
 NUDT21 |  CWC25 | 0.016 | 0.106           |
 PHRF1 |  RP9 | 0.015 | 0.122           |
 PHRF1 |  CWC25 | 0.014 | 0.142           |
 PUF60 |  DDX41 | 0.013 | 0.532           |
 PUF60 |  NUDT21 | 0.013 | 0.578           |
 CWC25 |  KHSRP | 0.012 | 0.13           |
 PUF60 |  CWC25 | 0.009 | 0.176           |
 PUF60 |  KHDRBS3 | 0.009 | 0.224           |
 PUF60 |  RP9 | 0.007 | 0.16           |
 KHSRP |  SCAF4 | 0.005 | 0.236           |
 PUF60 |  KHSRP | 0.003 | 0.654           |
 PRPF38A |  KHSRP | 0.003 | 0.162           |
 KHSRP |  SFSWAP | 0.003 | 0.15           |
 JMJD6 |  KHSRP | 0.001 | 0.19           |
 KHSRP |  PRPF38B | 0.001 | 0.144           |
 KHSRP |  DDX41 | 0.0 | 0.166           |
Related Complexes