hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11457.1
Complex Portal: CPX-22159
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCAPH | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | 5 | UniProt NCBI |
| GPR137B | Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein) | 5 | UniProt NCBI |
| KLKB1 | Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] | 5 | UniProt NCBI |
| TRIM38 | E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet) | 5 | UniProt NCBI |
| NCAPD3 | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | 5 | UniProt NCBI |
| NCAPD2 | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | 5 | UniProt NCBI |
| NCAPG2 | Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2) | 5 | UniProt NCBI |
| SMC4 | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | 5 | UniProt NCBI |
| NCAPG | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | 5 | UniProt NCBI |
| SMC2 | Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000796 | 1.70069372575e-18 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | condensin complex |
| GO:1905821 | 1.70069372575e-18 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | positive regulation of chromosome condensation |
| GO:0060623 | 2.55012376737e-17 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | regulation of chromosome condensation |
| CORUM:167 | 3.31256423358e-15 | 0.5 | NCAPH SMC2 NCAPG NCAPD2 SMC4 | Condensin I complex |
| CORUM:157 | 3.31256423358e-15 | 0.5 | NCAPH SMC2 NCAPG NCAPD2 SMC4 | Condensin I complex |
| CORUM:10 | 3.31256423358e-15 | 0.5 | NCAPH SMC2 NCAPG NCAPD2 SMC4 | Condensin I complex |
| CORUM:159 | 1.98697170849e-14 | 0.5 | NCAPH SMC2 NCAPG NCAPD2 SMC4 | Condensin I-PARP-1-XRCC1 complex |
| GO:0051984 | 2.50807537986e-13 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | positive regulation of chromosome segregation |
| GO:1905820 | 2.50807537986e-13 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | positive regulation of chromosome separation |
| GO:0030261 | 4.31075191565e-13 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | chromosome condensation |
| GO:0007076 | 3.87847613343e-12 | 0.6 | NCAPD3 NCAPD2 SMC2 NCAPG NCAPH SMC4 | mitotic chromosome condensation |
| REAC:R-HSA-2514853 | 5.05572175402e-12 | 0.5 | NCAPH SMC2 NCAPG NCAPD2 SMC4 | Condensation of Prometaphase Chromosomes |
| GO:0000794 | 1.13011078121e-11 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | condensed nuclear chromosome |
| CORUM:160 | 4.03199797571e-11 | 0.4 | NCAPD3 SMC2 SMC4 NCAPG2 | Condensin II |
| GO:1905818 | 1.63840637493e-10 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | regulation of chromosome separation |
| GO:0051304 | 3.09575584204e-10 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | chromosome separation |
| GO:2001252 | 4.75477463092e-09 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | positive regulation of chromosome organization |
| GO:0051983 | 1.16726094409e-08 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | regulation of chromosome segregation |
| GO:0000070 | 1.00801413132e-07 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | mitotic sister chromatid segregation |
| GO:0000228 | 1.67918026877e-07 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | nuclear chromosome |
| REAC:R-HSA-68886 | 2.34154077037e-07 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | M Phase |
| GO:0090068 | 2.80618624806e-07 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | positive regulation of cell cycle process |
| GO:0000819 | 4.68967544982e-07 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | sister chromatid segregation |
| GO:0000793 | 5.39438611834e-07 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | condensed chromosome |
| GO:0140014 | 1.11171621038e-06 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | mitotic nuclear division |
| GO:0033044 | 1.29722056719e-06 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | regulation of chromosome organization |
| GO:0098813 | 1.80051044163e-06 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | nuclear chromosome segregation |
| GO:0045787 | 1.85357767037e-06 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | positive regulation of cell cycle |
| REAC:R-HSA-69278 | 1.98415441168e-06 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 8.32723293103e-06 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | Cell Cycle |
| GO:0000280 | 1.14801626056e-05 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | nuclear division |
| REAC:R-HSA-2299718 | 1.27793125135e-05 | 0.4 | NCAPD3 SMC2 SMC4 NCAPG2 | Condensation of Prophase Chromosomes |
| GO:0007059 | 1.36862021135e-05 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | chromosome segregation |
| REAC:R-HSA-68877 | 2.31623318665e-05 | 0.5 | NCAPH SMC2 NCAPG NCAPD2 SMC4 | Mitotic Prometaphase |
| GO:0048285 | 2.59971732821e-05 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | organelle fission |
| CORUM:5239 | 3.07577115383e-05 | 0.2 | SMC4 SMC2 | CAP(C)-CAP(E) complex |
| GO:0010638 | 5.30154786565e-05 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | positive regulation of organelle organization |
| CORUM:353 | 9.22394575203e-05 | 0.2 | SMC4 SMC2 | DNA ligase IV-condensin complex |
| REAC:R-HSA-68875 | 0.000225524796323 | 0.4 | NCAPD3 SMC2 SMC4 NCAPG2 | Mitotic Prophase |
| GO:0051276 | 0.000296937740753 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | chromosome organization |
| GO:0010564 | 0.00058130042194 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | regulation of cell cycle process |
| CORUM:49 | 0.00064473409071 | 0.2 | SMC4 SMC2 | DNMT3B complex |
| GO:1903047 | 0.000999658920399 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | mitotic cell cycle process |
| GO:0000278 | 0.0037104493197 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | mitotic cell cycle |
| GO:0051130 | 0.00567480827352 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | positive regulation of cellular component organization |
| GO:0051726 | 0.00867855843311 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | regulation of cell cycle |
| GO:0033043 | 0.0164641748695 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | regulation of organelle organization |
| GO:0022402 | 0.0299417551952 | 0.7 | NCAPD3 NCAPG2 SMC2 NCAPD2 NCAPG NCAPH SMC4 | cell cycle process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NCAPD3 | NCAPG2 | 1.0 | 0.598 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo fraction | |
| SMC2 | SMC4 | 0.999 | 0.926 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| NCAPH | NCAPG | 0.999 | 0.954 |
structurally_consistent (Q15021)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction |
| NCAPG2 | SMC4 | 0.999 | 0.224 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () fraction boldt_WMM | |
| NCAPH | NCAPD2 | 0.998 | 0.944 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo fraction boldt_WMM |
| NCAPG | NCAPD2 | 0.998 | 0.964 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| NCAPG2 | SMC2 | 0.997 | 0.19 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () fraction boldt_WMM | |
| NCAPD3 | SMC4 | 0.993 | 0.16 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () fraction treiber_WMM | |
| SMC2 | NCAPG | 0.991 | 0.912 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| NCAPG2 | NCAPG | 0.991 | 0.194 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| NCAPD3 | SMC2 | 0.99 | 0.136 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () fraction | |
| NCAPD3 | NCAPG | 0.987 | 0.224 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCAPH | NCAPD3 | 0.986 | 0.12 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCAPH | SMC4 | 0.985 | 0.86 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction boldt_WMM | |
| NCAPH | NCAPG2 | 0.983 | 0.162 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCAPH | SMC2 | 0.981 | 0.84 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction boldt_WMM | |
| SMC2 | NCAPD2 | 0.981 | 0.93 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM | |
| SMC4 | NCAPD2 | 0.977 | 0.95 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () fraction boldt_WMM treiber_WMM | |
| SMC4 | NCAPG | 0.974 | 0.916 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM | |
| NCAPD3 | NCAPD2 | 0.96 | 0.158 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | |
| GPR137B | SMC4 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NCAPH | GPR137B | 0.928 |
mutually_exclusive (Q9BPX3)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KLKB1 | NCAPH | 0.919 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NCAPG2 | NCAPD2 | 0.911 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| GPR137B | NCAPD2 | 0.828 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TRIM38 | SMC2 | 0.811 | 0.044 | hein_WMM youn_WMM WMM_only | |
| GPR137B | SMC2 | 0.78 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GPR137B | NCAPG | 0.367 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KLKB1 | SMC4 | 0.015 | bioplex () | ||
| TRIM38 | NCAPG | 0.011 | 0.04 | youn_WMM WMM_only | |
| TRIM38 | SMC4 | 0.01 | 0.052 | youn_WMM WMM_only | |
| TRIM38 | NCAPH | 0.009 | 0.068 | youn_WMM WMM_only | |
| KLKB1 | NCAPD3 | 0.009 | bioplex () | ||
| KLKB1 | SMC2 | 0.006 | bioplex3_HEK293 WMM_only |
Related Complexes