hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11458.1

Complex Portal: CPX-16184

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
FANCB	Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95)	5	UniProt NCBI
FANCL	E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL)	5	UniProt NCBI
CDH16	Cadherin-16 (Kidney-specific cadherin) (Ksp-cadherin)	5	UniProt NCBI
GRK7	Rhodopsin kinase GRK7 (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7)	5	UniProt NCBI
FANCC	Fanconi anemia group C protein (Protein FACC)	5	UniProt NCBI
FAAP100	Fanconi anemia core complex-associated protein 100 (Fanconi anemia-associated protein of 100 kDa)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1624	6.71926075272e-11	0.666666666667	FANCL FAAP100 FANCB FANCC	FA core complex (Fanconi anemia core complex)
CORUM:245	6.71926075272e-11	0.666666666667	FANCL FAAP100 FANCB FANCC	FA core complex (Fanconi anemia core complex)
CORUM:6884	1.20933446315e-10	0.666666666667	FANCL FAAP100 FANCB FANCC	Fanconi anemia FAAP100 complex
CORUM:6885	4.67737426163e-09	0.5	FANCL FANCB FAAP100	L-B-P100 subcomplex
REAC:R-HSA-6783310	7.57200209391e-08	0.666666666667	FANCL FAAP100 FANCB FANCC	Fanconi Anemia Pathway
KEGG:03460	8.61424993064e-08	0.666666666667	FANCL FAAP100 FANCB FANCC	Fanconi anemia pathway
CORUM:1152	1.63607282644e-07	0.5	FANCL FANCB FANCC	FA complex (Fanconi anemia complex)
GO:0043240	1.9520016395e-07	0.666666666667	FANCL FAAP100 FANCB FANCC	Fanconi anaemia nuclear complex
CORUM:2739	5.6068011168e-07	0.5	FANCL FANCB FANCC	FA complex (Fanconi anemia complex)
WP:WP4946	3.60267251917e-06	0.666666666667	FANCL FAAP100 FANCB FANCC	DNA repair pathways full network
GO:0036297	1.60994442835e-05	0.666666666667	FANCL FAAP100 FANCB FANCC	interstrand cross-link repair
HP:0005522	4.54129898225e-05	0.5	FANCL FANCB FANCC	Pyridoxine-responsive sideroblastic anemia
HP:0010469	5.22168897407e-05	0.5	FANCL FANCB FANCC	Absent testis
GO:0006513	5.85430293603e-05	0.666666666667	FANCL FAAP100 FANCB FANCC	protein monoubiquitination
HP:0003974	5.96672480776e-05	0.5	FANCL FANCB FANCC	Absent radius
HP:0009822	6.77932406197e-05	0.5	FANCL FANCB FANCC	Aplasia involving forearm bones
HP:0003953	6.77932406197e-05	0.5	FANCL FANCB FANCC	Absent forearm bone
HP:0012848	8.6188740938e-05	0.5	FANCL FANCB FANCC	Small intestinal stenosis
HP:0100867	8.6188740938e-05	0.5	FANCL FANCB FANCC	Duodenal stenosis
HP:0010293	8.6188740938e-05	0.5	FANCL FANCB FANCC	Aplasia/Hypoplasia of the uvula
HP:0002245	9.65165097732e-05	0.5	FANCL FANCB FANCC	Meckel diverticulum
HP:0100760	9.65165097732e-05	0.5	FANCL FANCB FANCC	Clubbing of toes
HP:0100587	0.000119577601747	0.5	FANCL FANCB FANCC	Abnormal preputium morphology
HP:0001924	0.000146039911068	0.5	FANCL FANCB FANCC	Sideroblastic anemia
HP:0001549	0.00022859990461	0.5	FANCL FANCB FANCC	Abnormal ileum morphology
CORUM:1625	0.00025612721106	0.333333333333	FANCB FANCC	FA core complex (Fanconi anemia core complex)
HP:0000813	0.000416966817366	0.5	FANCL FANCB FANCC	Bicornuate uterus
REAC:R-HSA-73894	0.000502730176626	0.666666666667	FANCL FAAP100 FANCB FANCC	DNA Repair
HP:0007874	0.000508000048987	0.5	FANCL FANCB FANCC	Almond-shaped palpebral fissure
HP:0100026	0.000541046995004	0.5	FANCL FANCB FANCC	Arteriovenous malformation
HP:0003022	0.000611367064879	0.5	FANCL FANCB FANCC	Hypoplasia of the ulna
CORUM:248	0.000614368794823	0.333333333333	FANCL FANCC	BRAFT complex
HP:0003220	0.000648697584007	0.5	FANCL FANCB FANCC	Abnormality of chromosome stability
HP:0200005	0.000687513326152	0.5	FANCL FANCB FANCC	Abnormal shape of the palpebral fissure
HP:0009777	0.000687513326152	0.5	FANCL FANCB FANCC	Absent thumb
HP:0006495	0.000769715072349	0.5	FANCL FANCB FANCC	Aplasia/Hypoplasia of the ulna
HP:0007565	0.00085820130959	0.5	FANCL FANCB FANCC	Multiple cafe-au-lait spots
CORUM:244	0.000938276380634	0.333333333333	FANCL FANCC	BRAFT complex
HP:0001199	0.00122069304557	0.5	FANCL FANCB FANCC	Triphalangeal thumb
HP:0000072	0.00134028574518	0.5	FANCL FANCB FANCC	Hydroureter
HP:0009821	0.00160231496954	0.5	FANCL FANCB FANCC	Forearm undergrowth
HP:0006501	0.00167274695187	0.5	FANCL FANCB FANCC	Aplasia/Hypoplasia of the radius
HP:0008572	0.00197502349026	0.5	FANCL FANCB FANCC	External ear malformation
HP:0009380	0.00205587120443	0.5	FANCL FANCB FANCC	Aplasia of the fingers
HP:0002246	0.0023115348624	0.5	FANCL FANCB FANCC	Abnormal duodenum morphology
HP:0009824	0.0023115348624	0.5	FANCL FANCB FANCC	Upper limb undergrowth
HP:0005344	0.00249319307056	0.5	FANCL FANCB FANCC	Abnormal carotid artery morphology
HP:0002575	0.00288444095262	0.5	FANCL FANCB FANCC	Tracheoesophageal fistula
HP:0000027	0.00309448033966	0.5	FANCL FANCB FANCC	Azoospermia
HP:0006503	0.00320320212918	0.5	FANCL FANCB FANCC	Aplasia/hypoplasia involving forearm bones
HP:0012745	0.00485475790375	0.5	FANCL FANCB FANCC	Short palpebral fissure
HP:0008669	0.00561569644834	0.5	FANCL FANCB FANCC	Abnormal spermatogenesis
HP:0002863	0.00561569644834	0.5	FANCL FANCB FANCC	Myelodysplasia
HP:0001053	0.00577679393552	0.5	FANCL FANCB FANCC	Hypopigmented skin patches
HP:0010161	0.00577679393552	0.5	FANCL FANCB FANCC	Abnormal toe phalanx morphology
HP:0000957	0.00662835320171	0.5	FANCL FANCB FANCC	Cafe-au-lait spot
HP:0008055	0.00680807287808	0.5	FANCL FANCB FANCC	Aplasia/Hypoplasia affecting the uvea
HP:0008053	0.00680807287808	0.5	FANCL FANCB FANCC	Aplasia/Hypoplasia of the iris
HP:0000453	0.00680807287808	0.5	FANCL FANCB FANCC	Choanal atresia
HP:0002414	0.0069909928987	0.5	FANCL FANCB FANCC	Spina bifida
HP:0001217	0.00717714082957	0.5	FANCL FANCB FANCC	Clubbing
HP:0000415	0.00836335600305	0.5	FANCL FANCB FANCC	Abnormality of the choanae
HP:0009892	0.00841070885474	0.333333333333	FANCL FANCB	Anotia
HP:0008062	0.00857286967155	0.5	FANCL FANCB FANCC	Aplasia/Hypoplasia affecting the anterior segment of the eye
HP:0000324	0.00878583114312	0.5	FANCL FANCB FANCC	Facial asymmetry
HP:0010301	0.00900226782501	0.5	FANCL FANCB FANCC	Spinal dysraphism
HP:0009601	0.00922220710687	0.5	FANCL FANCB FANCC	Aplasia/Hypoplasia of the thumb
HP:0002023	0.00944567636069	0.5	FANCL FANCB FANCC	Anal atresia
HP:0000010	0.0108621519105	0.5	FANCL FANCB FANCC	Recurrent urinary tract infections
HP:0004362	0.0111110959064	0.5	FANCL FANCB FANCC	Abnormal enteric ganglion morphology
HP:0031105	0.0111110959064	0.5	FANCL FANCB FANCC	Abnormal uterus morphology
HP:0002251	0.0111110959064	0.5	FANCL FANCB FANCC	Aganglionic megacolon
HP:0003221	0.011317974846	0.333333333333	FANCL FANCC	Chromosomal breakage induced by crosslinking agents
HP:0012331	0.0113637882169	0.5	FANCL FANCB FANCC	Abnormal autonomic nervous system morphology
HP:0025028	0.0113637882169	0.5	FANCL FANCB FANCC	Abnormal enteric nervous system morphology
HP:0025633	0.0113637882169	0.5	FANCL FANCB FANCC	Abnormal ureter morphology
HP:0040071	0.0116202560559	0.5	FANCL FANCB FANCC	Abnormal morphology of ulna
HP:0001882	0.0118805266195	0.5	FANCL FANCB FANCC	Leukopenia
HP:0012041	0.0121446270864	0.5	FANCL FANCB FANCC	Decreased fertility in males
HP:0008517	0.0129324670968	0.333333333333	FANCL FANCB	Aplasia/Hypoplasia of the sacrum
HP:0002778	0.0159387886898	0.5	FANCL FANCB FANCC	Abnormal tracheal morphology
HP:0001646	0.0165841502586	0.5	FANCL FANCB FANCC	Abnormal aortic valve morphology
HP:0012145	0.0169132111595	0.5	FANCL FANCB FANCC	Abnormality of multiple cell lineages in the bone marrow
HP:0010468	0.0182726158894	0.5	FANCL FANCB FANCC	Aplasia/Hypoplasia of the testes
HP:0001562	0.0197023659792	0.5	FANCL FANCB FANCC	Oligohydramnios
HP:0001636	0.0208218734023	0.5	FANCL FANCB FANCC	Tetralogy of Fallot
HP:0000340	0.0219826348817	0.5	FANCL FANCB FANCC	Sloping forehead
HP:0010972	0.0219826348817	0.5	FANCL FANCB FANCC	Anemia of inadequate production
HP:0000172	0.0223788473695	0.5	FANCL FANCB FANCC	Abnormal uvula morphology
HP:0045058	0.023595733488	0.5	FANCL FANCB FANCC	Abnormality of the testis size
HP:0001034	0.0244307972482	0.5	FANCL FANCB FANCC	Hypermelanotic macule
HP:0000268	0.0257196332323	0.5	FANCL FANCB FANCC	Dolichocephaly
HP:0009602	0.0257196332323	0.5	FANCL FANCB FANCC	Abnormality of thumb phalanx
HP:0005561	0.0261590153267	0.5	FANCL FANCB FANCC	Abnormal bone marrow cell morphology
HP:0000104	0.0279660997661	0.5	FANCL FANCB FANCC	Renal agenesis
HP:0034915	0.0293741864658	0.5	FANCL FANCB FANCC	Abnormal anus morphology
HP:0002818	0.0293741864658	0.5	FANCL FANCB FANCC	Abnormal morphology of the radius
HP:0001010	0.0298537414198	0.5	FANCL FANCB FANCC	Hypopigmentation of the skin
HP:0006101	0.0303384366223	0.5	FANCL FANCB FANCC	Finger syndactyly
HP:0000483	0.0338774376034	0.5	FANCL FANCB FANCC	Astigmatism
HP:0000025	0.034936339568	0.5	FANCL FANCB FANCC	Functional abnormality of male internal genitalia
HP:0040072	0.0365652768554	0.5	FANCL FANCB FANCC	Abnormal forearm bone morphology
HP:0002973	0.0371191829266	0.5	FANCL FANCB FANCC	Abnormal forearm morphology
HP:0007400	0.0376785959704	0.5	FANCL FANCB FANCC	Irregular hyperpigmentation
HP:0004378	0.0376785959704	0.5	FANCL FANCB FANCC	Abnormality of the anus
HP:0002032	0.037751561683	0.333333333333	FANCL FANCB	Esophageal atresia
HP:0002031	0.0393901375023	0.5	FANCL FANCB FANCC	Abnormal esophagus morphology
HP:0012733	0.0393901375023	0.5	FANCL FANCB FANCC	Macule
HP:0001770	0.0454639361427	0.5	FANCL FANCB FANCC	Toe syndactyly
HP:0000130	0.0480563748242	0.5	FANCL FANCB FANCC	Abnormality of the uterus
HP:0100542	0.0487193538173	0.5	FANCL FANCB FANCC	Abnormal localization of kidney
HP:0009826	0.0487193538173	0.5	FANCL FANCB FANCC	Limb undergrowth

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
FANCL	FAAP100	0.995	0.175	hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM
FAAP100	FANCB	0.994	0.124	hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM
FANCL	FANCC	0.994		bioplex3_WMM bioplex3_HCT116 WMM_only
FANCB	FANCC	0.993		bioplex3_WMM bioplex3_HCT116 WMM_only
FANCL	FANCB	0.991	0.226	hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM
GRK7	FAAP100	0.988		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
CDH16	FANCL	0.975		bioplex3_HEK293 bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
FANCB	huMAP3_05216.1 huMAP3_05580.1 huMAP3_07422.1 huMAP3_09841.1 huMAP3_10668.1 huMAP3_11458.1 huMAP3_13616.1 huMAP3_13765.1 huMAP3_15070.1 huMAP3_15301.1
FANCL	huMAP3_00342.1 huMAP3_05216.1 huMAP3_05580.1 huMAP3_07422.1 huMAP3_07690.1 huMAP3_09841.1 huMAP3_10668.1 huMAP3_11458.1 huMAP3_13616.1 huMAP3_13765.1 huMAP3_14301.1 huMAP3_15070.1 huMAP3_15301.1
CDH16	huMAP3_00342.1 huMAP3_05216.1 huMAP3_05580.1 huMAP3_07690.1 huMAP3_09841.1 huMAP3_10668.1 huMAP3_11458.1 huMAP3_11598.1 huMAP3_13616.1 huMAP3_13765.1 huMAP3_14301.1
GRK7	huMAP3_00382.1 huMAP3_05331.1 huMAP3_10668.1 huMAP3_11458.1 huMAP3_12312.1 huMAP3_13616.1
FANCC	huMAP3_07422.1 huMAP3_09841.1 huMAP3_10668.1 huMAP3_11139.1 huMAP3_11458.1 huMAP3_13616.1 huMAP3_13765.1 huMAP3_15070.1 huMAP3_15301.1
FAAP100	huMAP3_00382.1 huMAP3_05331.1 huMAP3_10668.1 huMAP3_11458.1 huMAP3_12312.1 huMAP3_13616.1 huMAP3_15070.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11458.1

Complex Portal: CPX-16184