hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11460.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TBC1D17 | TBC1 domain family member 17 | 5 | UniProt NCBI |
| MMACHC | Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) | 5 | UniProt NCBI |
| MTHFR | Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53) | 5 | UniProt NCBI |
| BNIP5 | Protein BNIP5 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003286 | 0.000334337547576 | 0.5 | MMACHC MTHFR | Cystathioninemia |
| HP:0003658 | 0.000501460556964 | 0.5 | MMACHC MTHFR | Hypomethioninemia |
| HP:0002156 | 0.00120317586686 | 0.5 | MMACHC MTHFR | Homocystinuria |
| HP:0002160 | 0.00260592941411 | 0.5 | MMACHC MTHFR | Hyperhomocystinemia |
| HP:0033095 | 0.00260592941411 | 0.5 | MMACHC MTHFR | Increased sulfur amino acid level in urine |
| HP:0010919 | 0.00303997345979 | 0.5 | MMACHC MTHFR | Abnormal circulating homocysteine concentration |
| HP:0010901 | 0.00350734148159 | 0.5 | MMACHC MTHFR | Abnormal circulating methionine concentration |
| HP:0002625 | 0.00400802433742 | 0.5 | MMACHC MTHFR | Deep venous thrombosis |
| HP:0006827 | 0.00400802433742 | 0.5 | MMACHC MTHFR | Atrophy of the spinal cord |
| HP:0007344 | 0.0051092979876 | 0.5 | MMACHC MTHFR | Atrophy/Degeneration involving the spinal cord |
| HP:0010899 | 0.00771122114953 | 0.5 | MMACHC MTHFR | Abnormal circulating aspartate family amino acid concentration |
| HP:0004339 | 0.00844485194452 | 0.5 | MMACHC MTHFR | Abnormal circulating sulfur amino acid concentration |
| HP:0002204 | 0.0165423111708 | 0.5 | MMACHC MTHFR | Pulmonary embolism |
| HP:0033100 | 0.018706736024 | 0.5 | MMACHC MTHFR | Increased proteinogenic amino acid level in urine |
| WP:WP1495 | 0.0373138951921 | 0.25 | MTHFR | Glycine metabolism |
| REAC:R-HSA-3359474 | 0.0499436884912 | 0.25 | MMACHC | Defective MMACHC causes MAHCC |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BNIP5 | TBC1D17 | 0.966 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MMACHC | BNIP5 | 0.96 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| BNIP5 | MTHFR | 0.866 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MMACHC | TBC1D17 | 0.076 | 0.07 | bioplex3_WMM WMM_only |
| MTHFR | TBC1D17 | 0.069 | 0.042 | bioplex3_WMM WMM_only |
| MMACHC | MTHFR | 0.062 | 0.09 | bioplex3_WMM WMM_only |
Related Complexes