hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11467.1
Complex Portal: CPX-13608
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IFRD2 | Interferon-related developmental regulator 2 (Protein SKMC15) | 4 | UniProt NCBI |
| DRG1 | Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-) | 5 | UniProt NCBI |
| SUB1 | Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14) | 5 | UniProt NCBI |
| THUMPD2 | THUMP domain-containing protein 2 | 3 | UniProt NCBI |
| EIF1AX | Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (eIF1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) | 5 | UniProt NCBI |
| PSIP1 | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | 5 | UniProt NCBI |
| ZC3H15 | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | 5 | UniProt NCBI |
| BUD23 | Probable 18S rRNA (guanine-N(7))-methyltransferase (EC 2.1.1.-) (Bud site selection protein 23 homolog) (Metastasis-related methyltransferase 1) (Williams-Beuren syndrome chromosomal region 22 protein) (rRNA methyltransferase and ribosome maturation factor) | 5 | UniProt NCBI |
| EIF1AY | Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (eIF1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) | 4 | UniProt NCBI |
| TRMT112 | Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070476 | 0.0210690324038 | 0.2 | BUD23 TRMT112 | rRNA (guanine-N7)-methylation |
| WP:WP107 | 0.0479442074014 | 0.2 | EIF1AY EIF1AX | Translation factors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ZC3H15 | DRG1 | 0.998 | 0.908 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM fraction boldt_WMM | |
| TRMT112 | BUD23 | 0.998 | 0.508 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF1AX | IFRD2 | 0.966 | 0.074 | hein_WMM bioplex3_WMM WMM_only | |
| EIF1AY | EIF1AX | 0.96 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EIF1AX | BUD23 | 0.914 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PSIP1 | DRG1 | 0.913 | 0.15 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| EIF1AX | PSIP1 | 0.863 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TRMT112 | THUMPD2 | 0.859 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DRG1 | BUD23 | 0.839 | 0.274 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PSIP1 | BUD23 | 0.833 | 0.086 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EIF1AX | TRMT112 | 0.83 | 0.342 | hein_WMM bioplex3_WMM WMM_only | |
| DRG1 | IFRD2 | 0.824 | 0.104 | hein_WMM bioplex3_HEK293 bioplex () Guru bioplex3_WMM youn_WMM fraction | |
| EIF1AX | SUB1 | 0.813 | 0.098 | Guru bioplex3_WMM fraction | |
| IFRD2 | BUD23 | 0.809 | 0.136 | hein_WMM bioplex3_WMM WMM_only | |
| DRG1 | TRMT112 | 0.695 | 0.23 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction | |
| PSIP1 | IFRD2 | 0.613 | 0.024 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| IFRD2 | TRMT112 | 0.518 | 0.098 | hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IFRD2 | SUB1 | 0.497 | 0.052 | bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM fraction | |
| PSIP1 | TRMT112 | 0.44 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM fraction | |
| EIF1AX | DRG1 | 0.414 | 0.35 | hein_WMM bioplex_WMM bioplex3_WMM fraction | |
| ZC3H15 | IFRD2 | 0.284 | 0.11 | bioplex3_HEK293 bioplex () bioplex3_WMM fraction | |
| EIF1AY | IFRD2 | 0.205 | 0.048 | bioplex3_HEK293 bioplex () bioplex3_WMM | |
| ZC3H15 | BUD23 | 0.184 | 0.248 | bioplex3_WMM fraction | |
| EIF1AX | ZC3H15 | 0.163 | 0.158 | bioplex3_WMM WMM_only | |
| ZC3H15 | SUB1 | 0.058 | 0.088 | bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| PSIP1 | ZC3H15 | 0.057 | 0.122 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| BUD23 | SUB1 | 0.054 | 0.02 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EIF1AY | SUB1 | 0.022 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM treiber_WMM | |
| PSIP1 | SUB1 | 0.02 | 0.174 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| EIF1AY | DRG1 | 0.014 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EIF1AY | BUD23 | 0.012 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ZC3H15 | TRMT112 | 0.011 | 0.168 | bioplex3_WMM youn_WMM gupta_WMM fraction | |
| EIF1AY | TRMT112 | 0.01 | 0.02 | bioplex3_HEK293 bioplex () bioplex3_WMM | |
| DRG1 | SUB1 | 0.009 | 0.166 | bioplex_WMM bioplex3_WMM boldt youn_WMM fraction boldt_WMM | |
| SUB1 | THUMPD2 | 0.008 | 0.108 | bioplex3_HEK293 bioplex () | |
| TRMT112 | SUB1 | 0.006 | 0.068 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EIF1AY | PSIP1 | 0.005 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| EIF1AY | ZC3H15 | 0.005 | 0.032 | bioplex3_HEK293 bioplex () bioplex3_WMM gupta_WMM | |
| EIF1AY | THUMPD2 | 0.003 | 0.082 | bioplex3_HEK293 bioplex () | |
| PSIP1 | THUMPD2 | 0.003 | 0.06 | bioplex3_HEK293 bioplex () |
Related Complexes