hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11472.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STK4 | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | 5 | UniProt NCBI |
| STK3 | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | 5 | UniProt NCBI |
| RASSF1 | Ras association domain-containing protein 1 | 5 | UniProt NCBI |
| RASSF2 | Ras association domain-containing protein 2 | 5 | UniProt NCBI |
| RASSF6 | Ras association domain-containing protein 6 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 1.90728148797e-09 | 0.8 | RASSF1 RASSF6 STK3 RASSF2 | Hippo signaling pathway - multiple species |
| CORUM:6716 | 4.09448956317e-05 | 0.4 | STK4 STK3 | DLG5-MST1-MST2 complex |
| WP:WP5087 | 0.000127149559662 | 0.8 | RASSF1 RASSF6 STK3 RASSF2 | Pleural mesothelioma |
| KEGG:04390 | 0.000467209213785 | 0.6 | RASSF1 STK3 RASSF6 | Hippo signaling pathway |
| WP:WP4537 | 0.00100346979189 | 0.4 | RASSF1 STK3 | Hippo YAP signaling |
| REAC:R-HSA-2028269 | 0.00259338296865 | 0.4 | STK4 STK3 | Signaling by Hippo |
| GO:0050821 | 0.00685002760202 | 0.8 | RASSF1 RASSF2 STK4 STK3 | protein stabilization |
| WP:WP3959 | 0.00774618498599 | 0.4 | RASSF1 STK3 | DNA IR double strand breaks and cellular response via ATM |
| KEGG:05223 | 0.0102617382696 | 0.4 | RASSF1 STK4 | Non-small cell lung cancer |
| WP:WP4255 | 0.0128896073912 | 0.4 | RASSF1 STK4 | Non small cell lung cancer |
| GO:0031647 | 0.0276602054215 | 0.8 | RASSF1 RASSF2 STK4 STK3 | regulation of protein stability |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| STK4 | RASSF1 | 1.0 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| STK3 | RASSF1 | 1.0 | 0.106 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| STK4 | RASSF2 | 0.999 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| STK4 | STK3 | 0.999 | 0.266 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| STK3 | RASSF2 | 0.999 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| STK4 | RASSF6 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| STK3 | RASSF6 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes