hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11482.1
Complex Portal: CPX-11949
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARHGAP24 | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | 5 | UniProt NCBI |
| TK2 | Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (2'-deoxyuridine kinase TK2) (EC 2.7.1.74) (Deoxycytidine kinase TK2) (EC 2.7.1.-) (Mt-TK) | 5 | UniProt NCBI |
| DKK1 | Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012531 | 0.0434073386094 | 1.0 | DKK1 ARHGAP24 TK2 | Pain |
| HP:0000763 | 0.047155317063 | 0.666666666667 | DKK1 TK2 | Sensory neuropathy |
| CORUM:7544 | 0.0499402709677 | 0.333333333333 | DKK1 | DKK1-KREMEN1-LRP6 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DKK1 | TK2 | 0.999 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ARHGAP24 | DKK1 | 0.995 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARHGAP24 | TK2 | 0.303 | 0.113142857143 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| ARHGAP24 | huMAP3_03075.1 huMAP3_11482.1 |
| TK2 | huMAP3_04191.1 huMAP3_07363.1 huMAP3_08163.1 huMAP3_09464.1 huMAP3_11479.1 huMAP3_11482.1 huMAP3_11872.1 huMAP3_15078.1 |
| DKK1 | huMAP3_03075.1 huMAP3_11482.1 |