hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11493.1

Complex Portal: CPX-11032

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
AP3B1	AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)	5	UniProt NCBI
EPB41L3	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]	5	UniProt NCBI
EPB41L2	Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G)	5	UniProt NCBI
EPB41	Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1)	5	UniProt NCBI
AP3M2	AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B)	5	UniProt NCBI
AP3M1	AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin)	5	UniProt NCBI
AP3D1	AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin)	5	UniProt NCBI
AP3S2	AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b)	5	UniProt NCBI
AP3B2	AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP)	5	UniProt NCBI
SCML1	Sex comb on midleg-like protein 1	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:59	3.52919404404e-18	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	AP3 adaptor complex
GO:0035654	2.17398353113e-15	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	clathrin-coated vesicle cargo loading, AP-3-mediated
GO:0035652	2.17398353113e-15	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	clathrin-coated vesicle cargo loading
CORUM:652	2.51982178335e-15	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	AP3-BLOC1 complex
GO:0030123	2.60786186274e-14	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	AP-3 adaptor complex
GO:0048490	5.75424749836e-12	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	anterograde synaptic vesicle transport
GO:0099514	5.75424749836e-12	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	synaptic vesicle cytoskeletal transport
GO:0099517	5.75424749836e-12	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	synaptic vesicle transport along microtubule
GO:0035459	2.27701408273e-10	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	vesicle cargo loading
GO:0048489	2.80198489354e-10	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	synaptic vesicle transport
GO:0030119	5.01622720499e-10	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	AP-type membrane coat adaptor complex
GO:0097479	7.18199869363e-10	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	synaptic vesicle localization
KEGG:04142	1.30735181881e-09	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	Lysosome
GO:0047496	1.38809802007e-09	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	vesicle transport along microtubule
GO:0008089	1.61916207817e-09	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	anterograde axonal transport
GO:0098930	7.95494071982e-09	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	axonal transport
GO:0008088	1.54036817355e-08	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	axo-dendritic transport
GO:0016183	1.65724193228e-08	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	synaptic vesicle coating
GO:0099518	2.08944516331e-08	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	vesicle cytoskeletal trafficking
GO:0072384	4.39801891241e-08	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	organelle transport along microtubule
GO:0070142	1.1594342202e-07	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	synaptic vesicle budding
GO:0016185	1.1594342202e-07	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	synaptic vesicle budding from presynaptic endocytic zone membrane
GO:0048475	1.54633511862e-07	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	coated membrane
GO:0030117	1.54633511862e-07	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	membrane coat
GO:0010970	2.38562301447e-06	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	transport along microtubule
GO:0099111	4.88279931126e-06	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	microtubule-based transport
GO:0051650	8.6121214011e-06	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	establishment of vesicle localization
GO:1903232	1.01062722265e-05	0.444444444444	AP3D1 AP3B1 AP3S2 AP3M1	melanosome assembly
GO:0030705	1.02870456841e-05	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	cytoskeleton-dependent intracellular transport
GO:0051648	1.06525470456e-05	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	vesicle localization
GO:0060155	1.97504384826e-05	0.444444444444	AP3D1 AP3B1 AP3S2 AP3M1	platelet dense granule organization
CORUM:2307	2.73623797451e-05	0.222222222222	AP3D1 AP3S2	AP3D1-AP3S2 complex
WP:WP5408	7.24291195209e-05	0.333333333333	AP3M2 AP3B2 AP3D1	15q25 copy number variation
GO:0005769	0.000150819802301	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	early endosome
GO:0007018	0.000154207033683	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	microtubule-based movement
GO:0006901	0.000172125683501	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	vesicle coating
GO:0016050	0.00019169778958	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	vesicle organization
GO:0048753	0.000193588306398	0.444444444444	AP3D1 AP3B1 AP3S2 AP3M1	pigment granule organization
GO:0032438	0.000193588306398	0.444444444444	AP3D1 AP3B1 AP3S2 AP3M1	melanosome organization
GO:0033363	0.000242456263636	0.444444444444	AP3D1 AP3B1 AP3S2 AP3M1	secretory granule organization
GO:0048488	0.000488457397695	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	synaptic vesicle endocytosis
GO:0140238	0.000488457397695	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	presynaptic endocytosis
GO:0051656	0.000948805948679	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	establishment of organelle localization
GO:0036465	0.00103422373522	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	synaptic vesicle recycling
GO:0033059	0.00111503328238	0.444444444444	AP3D1 AP3B1 AP3S2 AP3M1	cellular pigmentation
HP:0011125	0.00306165140522	0.222222222222	AP3B1 AP3D1	Abnormality of dermal melanosomes
GO:0006900	0.00334782846127	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	vesicle budding from membrane
GO:0043473	0.00354093280479	0.444444444444	AP3D1 AP3B1 AP3S2 AP3M1	pigmentation
GO:0051640	0.00409383984994	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	organelle localization
GO:0099504	0.0154150912184	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	synaptic vesicle cycle
GO:0099003	0.0172675356747	0.444444444444	AP3S2 AP3M2 AP3B2 AP3D1	vesicle-mediated transport in synapse
WP:WP4148	0.0202568688475	0.222222222222	EPB41L3 EPB41L2	Splicing factor NOVA regulated synaptic proteins
HP:0001022	0.0366109494459	0.222222222222	AP3B1 AP3D1	Albinism
GO:0007017	0.0416877457662	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	microtubule-based process
GO:0005768	0.047286302086	0.666666666667	AP3B1 AP3M1 AP3D1 AP3B2 AP3S2 AP3M2	endosome

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
AP3M1	AP3B2	1.0	0.044	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
AP3B1	AP3M1	1.0	0.782	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM
AP3M1	AP3D1	1.0	0.794	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
EPB41L3	EPB41L2	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
AP3B1	AP3M2	0.999	0.28	mutually_exclusive (Q9Y2T2)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction
EPB41L3	AP3M2	0.998			bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
AP3M2	AP3M1	0.998	0.636	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
EPB41L3	AP3B1	0.996			bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
EPB41L3	AP3M1	0.995			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
AP3M2	AP3D1	0.995	0.604		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction
AP3B1	AP3D1	0.993	0.806	mutually_exclusive (Q9Y2T2) structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM
AP3M1	AP3S2	0.991	0.068	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
AP3B1	AP3B2	0.991	0.04	mutually_exclusive (Q9Y2T2)	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41L3	EPB41	0.991			bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only
AP3M2	AP3B2	0.98	0.036	mutually_exclusive (Q9Y2T2)	bioplex_WMM bioplex3_WMM WMM_only
AP3M2	AP3S2	0.978	0.074	mutually_exclusive (Q9Y2T2)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
EPB41L3	AP3D1	0.971			bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
AP3D1	AP3S2	0.938	0.136	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
AP3D1	AP3B2	0.921	0.038	mutually_exclusive (Q9Y2T2)	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41L3	AP3B2	0.913			bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41L3	SCML1	0.906			bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only
EPB41	EPB41L2	0.887	0.054		bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
AP3B1	AP3S2	0.834	0.066	structurally_consistent (O14617)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
EPB41	SCML1	0.826			bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only
AP3S2	AP3B2	0.747	0.06		bioplex_WMM bioplex3_WMM WMM_only
EPB41L3	AP3S2	0.741			bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only
EPB41L2	SCML1	0.722			bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only
SCML1	AP3S2	0.097			bioplex3_WMM WMM_only
SCML1	AP3M2	0.097			bioplex3_WMM WMM_only
SCML1	AP3B2	0.087			bioplex3_WMM WMM_only
EPB41L2	AP3B1	0.063	0.082		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM
EPB41L2	AP3M1	0.061	0.046		bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM gupta_WMM bioplex_WMM
SCML1	AP3B1	0.049			bioplex3_WMM youn_WMM WMM_only
EPB41L2	AP3M2	0.047	0.056		bioplex3_WMM youn_WMM WMM_only
SCML1	AP3D1	0.041			bioplex3_WMM youn_WMM WMM_only
SCML1	AP3M1	0.028			bioplex3_WMM youn_WMM WMM_only
EPB41L2	AP3D1	0.022	0.132		bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
EPB41	AP3M1	0.015	0.046		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
EPB41	AP3B1	0.013	0.048		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41	AP3M2	0.013	0.032		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41	AP3B2	0.013	0.058		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
EPB41L2	AP3B2	0.011	0.044		bioplex3_WMM youn_WMM WMM_only
EPB41L2	AP3S2	0.008	0.038		bioplex3_WMM youn_WMM WMM_only
EPB41	AP3D1	0.006	0.044		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41	AP3S2	0.005	0.062		bioplex3_WMM youn_WMM WMM_only

Related Complexes

Genename	Complexes
AP3B1	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04281.1 huMAP3_06230.1 huMAP3_11077.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_13786.1 huMAP3_14281.1 huMAP3_15082.1
EPB41L3	huMAP3_00103.1 huMAP3_07467.1 huMAP3_08647.1 huMAP3_09803.1 huMAP3_11077.1 huMAP3_11121.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_12829.1 huMAP3_14281.1 huMAP3_15082.1
EPB41L2	huMAP3_00373.1 huMAP3_00489.1 huMAP3_00734.1 huMAP3_08365.1 huMAP3_08647.1 huMAP3_09637.1 huMAP3_09803.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_11077.1 huMAP3_11493.1
EPB41	huMAP3_00103.1 huMAP3_04708.1 huMAP3_07467.1 huMAP3_08647.1 huMAP3_09803.1 huMAP3_11077.1 huMAP3_11121.1 huMAP3_11493.1 huMAP3_12217.1 huMAP3_12829.1 huMAP3_15035.1
AP3M2	huMAP3_03149.1 huMAP3_04148.1 huMAP3_04238.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
AP3M1	huMAP3_03149.1 huMAP3_04148.1 huMAP3_04238.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
AP3D1	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04238.1 huMAP3_06230.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
AP3S2	huMAP3_03149.1 huMAP3_03809.1 huMAP3_04148.1 huMAP3_04238.1 huMAP3_06631.1 huMAP3_07739.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
AP3B2	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04238.1 huMAP3_06230.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
SCML1	huMAP3_01025.1 huMAP3_01972.1 huMAP3_03635.1 huMAP3_07122.1 huMAP3_07970.1 huMAP3_09181.1 huMAP3_09551.1 huMAP3_10162.1 huMAP3_10209.1 huMAP3_11493.1 huMAP3_12829.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11493.1

Complex Portal: CPX-11032