hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11506.1

Complex Portal: CPX-24456

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
PRRT4	Proline-rich transmembrane protein 4	3	UniProt NCBI
PITPNM1	Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)	5	UniProt NCBI
RASSF1	Ras association domain-containing protein 1	5	UniProt NCBI
PITPNM2	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	5	UniProt NCBI
OSBP2	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4)	5	UniProt NCBI
OSBPL9	Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)	5	UniProt NCBI
SLC22A15	Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)	5	UniProt NCBI
RAB3GAP2	Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit)	5	UniProt NCBI
OSBPL10	Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10)	5	UniProt NCBI
PITPNM3	Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1)	5	UniProt NCBI
OSBPL2	Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)	5	UniProt NCBI
VAPA	Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)	5	UniProt NCBI
RAB3GAP1	Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP)	5	UniProt NCBI
OSBPL11	Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)	5	UniProt NCBI
USP33	Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)	5	UniProt NCBI
MYL4	Myosin light chain 4 (Myosin light chain 1, embryonic muscle/atrial isoform) (Myosin light chain alkali GT-1 isoform)	5	UniProt NCBI
RASSF3	Ras association domain-containing protein 3	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005319	7.01068108106e-09	0.5	OSBPL11 OSBPL10 OSBP2 PITPNM3 PITPNM2 OSBPL2 OSBPL9 PITPNM1	lipid transporter activity
GO:0015248	2.55331552972e-06	0.3125	OSBP2 OSBPL2 OSBPL11 OSBPL10 OSBPL9	sterol transporter activity
REAC:R-HSA-1483226	3.14359141046e-06	0.1875	PITPNM3 PITPNM1 PITPNM2	Synthesis of PI
GO:0008526	3.34342729474e-06	0.25	OSBPL2 PITPNM3 PITPNM1 PITPNM2	phosphatidylinositol transfer activity
GO:0005548	3.26892151473e-05	0.3125	OSBPL10 PITPNM3 OSBPL2 PITPNM1 PITPNM2	phospholipid transporter activity
GO:0032934	5.87607676074e-05	0.3125	OSBP2 OSBPL2 OSBPL11 OSBPL10 OSBPL9	sterol binding
GO:0120014	0.000229594433106	0.25	OSBPL2 PITPNM3 PITPNM1 PITPNM2	phospholipid transfer activity
GO:0005496	0.000288967006385	0.3125	OSBP2 OSBPL2 OSBPL11 OSBPL10 OSBPL9	steroid binding
REAC:R-HSA-556833	0.000524545448156	0.4375	OSBPL9 PITPNM3 PITPNM2 OSBPL2 OSBPL10 VAPA PITPNM1	Metabolism of lipids
REAC:R-HSA-1483206	0.00125261092449	0.25	OSBPL10 PITPNM3 PITPNM1 PITPNM2	Glycerophospholipid biosynthesis
GO:0005215	0.00129407080238	0.5625	OSBPL11 OSBPL10 OSBP2 SLC22A15 PITPNM2 OSBPL2 OSBPL9 PITPNM1 PITPNM3	transporter activity
GO:0120013	0.00384929632588	0.25	OSBPL2 PITPNM3 PITPNM1 PITPNM2	lipid transfer activity
REAC:R-HSA-1483257	0.00965951100191	0.25	OSBPL10 PITPNM3 PITPNM1 PITPNM2	Phospholipid metabolism
HP:0100952	0.0121905443004	0.125	RAB3GAP1 RAB3GAP2	Enlarged sylvian cistern
GO:0008289	0.0273724502911	0.4375	OSBPL11 OSBPL10 OSBP2 PITPNM2 OSBPL2 OSBPL9 PITPNM1	lipid binding

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
RAB3GAP2	RAB3GAP1	0.999	0.936	structurally_consistent (dimer)
VAPA	OSBPL2	0.999	0.074
VAPA	OSBPL9	0.998	0.106
OSBPL9	OSBPL11	0.997	0.428
VAPA	OSBPL11	0.997	0.068
VAPA	OSBP2	0.997	0.142
VAPA	OSBPL10	0.994	0.032
VAPA	PITPNM3	0.992
VAPA	PITPNM1	0.983	0.11	structurally_consistent (dimer)
SLC22A15	VAPA	0.957
VAPA	PITPNM2	0.944	0.104363095238	structurally_consistent (dimer)
VAPA	RAB3GAP2	0.918	0.052
SLC22A15	OSBPL2	0.904
PRRT4	RASSF1	0.904
SLC22A15	RASSF3	0.904
PRRT4	PITPNM2	0.902
OSBP2	PRRT4	0.902
PRRT4	OSBPL2	0.902
SLC22A15	PITPNM2	0.902
PITPNM1	RASSF3	0.902	0.088
PITPNM3	PRRT4	0.902
PITPNM2	RASSF3	0.902	0.072
SLC22A15	PRRT4	0.902
SLC22A15	PITPNM1	0.902
PRRT4	RASSF3	0.902
PITPNM1	PRRT4	0.902
OSBP2	PITPNM2	0.897	0.082
PITPNM1	OSBP2	0.897	0.108
PRRT4	OSBPL9	0.892
SLC22A15	RASSF1	0.892
PRRT4	OSBPL11	0.892
VAPA	USP33	0.89	0.158
OSBPL11	RAB3GAP1	0.889	0.11
PITPNM1	PITPNM2	0.881	0.086	mutually_exclusive (Q9P0L0)
OSBPL11	RAB3GAP2	0.88	0.104
PITPNM1	OSBPL10	0.88	0.064
PITPNM2	OSBPL10	0.88	0.036
OSBPL2	RASSF3	0.869	0.056
OSBP2	OSBPL9	0.862	0.138
OSBPL11	MYL4	0.857	0.01
OSBP2	OSBPL10	0.849	0.09
PITPNM3	PITPNM2	0.843
PITPNM1	PITPNM3	0.843
PITPNM1	RASSF1	0.828	0.068
USP33	RAB3GAP1	0.826	0.112
PITPNM3	USP33	0.818
RASSF3	RASSF1	0.81	0.09
PITPNM2	OSBPL2	0.797	0.086
PITPNM1	OSBPL2	0.797	0.088
PITPNM3	RASSF1	0.793
PITPNM3	OSBPL2	0.793
VAPA	RAB3GAP1	0.792	0.048
PITPNM2	RASSF1	0.781	0.06
PITPNM3	OSBP2	0.778
OSBPL9	USP33	0.778	0.296
PITPNM1	OSBPL11	0.772	0.044
PITPNM2	OSBPL11	0.772	0.07
PITPNM1	OSBPL9	0.772	0.056
PITPNM2	OSBPL9	0.772	0.062
SLC22A15	OSBPL11	0.768
RAB3GAP2	OSBPL10	0.761	0.102
PRRT4	RAB3GAP1	0.754
OSBPL9	MYL4	0.746	0.016
PITPNM1	RAB3GAP1	0.739	0.062
OSBPL2	RASSF1	0.739	0.082
PITPNM2	RAB3GAP1	0.739	0.04
PRRT4	RAB3GAP2	0.737
OSBPL9	RAB3GAP1	0.733	0.136
RAB3GAP1	RASSF1	0.729	0.092
PITPNM3	RASSF3	0.722
SLC22A15	OSBP2	0.722
SLC22A15	PITPNM3	0.717
OSBP2	OSBPL11	0.716	0.128
OSBPL9	RASSF3	0.715	0.044
SLC22A15	RAB3GAP1	0.715
OSBPL11	RASSF3	0.715	0.062
OSBPL11	RASSF1	0.704	0.102
OSBPL9	RASSF1	0.704	0.164
OSBPL2	OSBPL11	0.701	0.026
PITPNM1	USP33	0.699	0.054
PITPNM2	USP33	0.699	0.064
SLC22A15	OSBPL9	0.697
OSBPL2	RAB3GAP1	0.682	0.044
OSBPL9	OSBPL2	0.681	0.056
PRRT4	OSBPL10	0.676
PRRT4	USP33	0.675
RAB3GAP1	RASSF3	0.675	0.044
VAPA	RASSF1	0.673	0.100194444444
SLC22A15	USP33	0.663
PITPNM3	RAB3GAP1	0.652
OSBP2	RASSF3	0.647	0.066
OSBPL2	OSBPL10	0.641	0.02
SLC22A15	OSBPL10	0.633
OSBPL11	USP33	0.63	0.074
PITPNM3	OSBPL11	0.625
OSBPL9	OSBPL10	0.624	0.804
OSBPL11	OSBPL10	0.624	0.528
OSBPL10	RASSF1	0.623	0.08
PITPNM3	OSBPL10	0.617
OSBP2	USP33	0.614	0.088
USP33	RASSF1	0.614	0.132
PITPNM3	OSBPL9	0.611
USP33	RAB3GAP2	0.604	0.208
PITPNM3	RAB3GAP2	0.603
OSBP2	RASSF1	0.594	0.09
OSBP2	OSBPL2	0.594	0.1
PITPNM2	RAB3GAP2	0.58	0.098
PITPNM1	RAB3GAP2	0.58	0.114
OSBPL2	USP33	0.572	0.058
USP33	RASSF3	0.552	0.09
RAB3GAP2	RASSF1	0.548	0.166
OSBP2	RAB3GAP1	0.548	0.068
RAB3GAP1	OSBPL10	0.539	0.058
OSBPL9	RAB3GAP2	0.539	0.086
USP33	OSBPL10	0.475	0.122
OSBP2	RAB3GAP2	0.445	0.116
RASSF3	OSBPL10	0.401	0.032
SLC22A15	RAB3GAP2	0.388
RAB3GAP2	RASSF3	0.343	0.064
OSBPL2	RAB3GAP2	0.339	0.064
VAPA	PRRT4	0.188
VAPA	RASSF3	0.099	0.082

Related Complexes

Genename	Complexes
PRRT4	huMAP3_00802.1 huMAP3_01083.1 huMAP3_01422.1 huMAP3_03470.1 huMAP3_06849.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
PITPNM1	huMAP3_00112.1 huMAP3_00443.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
RASSF1	huMAP3_10317.1 huMAP3_11472.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12772.1 huMAP3_13169.1 huMAP3_14729.1
PITPNM2	huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07722.1 huMAP3_08743.1 huMAP3_09375.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
OSBP2	huMAP3_00802.1 huMAP3_00862.1 huMAP3_01422.1 huMAP3_03016.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_08942.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_12614.1 huMAP3_12946.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1 huMAP3_14847.1
OSBPL9	huMAP3_00802.1 huMAP3_01422.1 huMAP3_01764.1 huMAP3_01831.1 huMAP3_03880.1 huMAP3_08937.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_13000.1 huMAP3_13169.1 huMAP3_14473.1
SLC22A15	huMAP3_00112.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11633.1 huMAP3_11729.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
RAB3GAP2	huMAP3_01063.1 huMAP3_04734.1 huMAP3_07014.1 huMAP3_07983.1 huMAP3_11130.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_14177.1 huMAP3_14856.1
OSBPL10	huMAP3_07560.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
PITPNM3	huMAP3_00750.1 huMAP3_00802.1 huMAP3_02032.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11833.1 huMAP3_12915.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
OSBPL2	huMAP3_00802.1 huMAP3_01468.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14729.1
VAPA	huMAP3_00112.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_14473.1
RAB3GAP1	huMAP3_01063.1 huMAP3_04734.1 huMAP3_07014.1 huMAP3_07588.1 huMAP3_07937.1 huMAP3_11130.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12653.1 huMAP3_13964.1 huMAP3_14131.1 huMAP3_14177.1 huMAP3_14473.1 huMAP3_14623.1 huMAP3_14791.1 huMAP3_15032.1
OSBPL11	huMAP3_00802.1 huMAP3_01422.1 huMAP3_01764.1 huMAP3_01831.1 huMAP3_03880.1 huMAP3_08937.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11815.1 huMAP3_13000.1 huMAP3_14177.1 huMAP3_14856.1
USP33	huMAP3_00802.1 huMAP3_01370.1 huMAP3_01422.1 huMAP3_04282.1 huMAP3_06849.1 huMAP3_07360.1 huMAP3_08743.1 huMAP3_10759.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13964.1 huMAP3_14131.1 huMAP3_14473.1 huMAP3_14623.1 huMAP3_14791.1 huMAP3_15032.1
MYL4	huMAP3_11485.1 huMAP3_11506.1 huMAP3_11815.1 huMAP3_13000.1 huMAP3_13982.1 huMAP3_14177.1 huMAP3_14856.1
RASSF3	huMAP3_01602.1 huMAP3_04903.1 huMAP3_07687.1 huMAP3_07691.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12772.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1 huMAP3_15155.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11506.1

Complex Portal: CPX-24456