hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11522.1
Complex Portal: CPX-20805
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRPF40B | Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) | 5 | UniProt NCBI |
| GNB5 | Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) | 5 | UniProt NCBI |
| RGS6 | Regulator of G-protein signaling 6 (RGS6) (S914) | 5 | UniProt NCBI |
| RGS7 | Regulator of G-protein signaling 7 (RGS7) | 5 | UniProt NCBI |
| RGS9 | Regulator of G-protein signaling 9 (RGS9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6814122 | 2.23277738459e-08 | 0.8 | RGS6 RGS9 GNB5 RGS7 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-390466 | 8.61057377169e-07 | 0.8 | RGS6 RGS9 GNB5 RGS7 | Chaperonin-mediated protein folding |
| WP:WP536 | 1.02045626229e-06 | 0.8 | RGS6 RGS9 GNB5 RGS7 | Calcium regulation in cardiac cells |
| REAC:R-HSA-391251 | 1.18778119207e-06 | 0.8 | RGS6 RGS9 GNB5 RGS7 | Protein folding |
| WP:WP289 | 1.92306432459e-06 | 0.8 | RGS6 RGS9 GNB5 RGS7 | Myometrial relaxation and contraction pathways |
| REAC:R-HSA-418594 | 2.04162706146e-05 | 0.8 | RGS6 RGS9 GNB5 RGS7 | G alpha (i) signalling events |
| REAC:R-HSA-388396 | 0.000311311377346 | 0.8 | RGS6 RGS9 GNB5 RGS7 | GPCR downstream signalling |
| REAC:R-HSA-372790 | 0.000523441642203 | 0.8 | RGS6 RGS9 GNB5 RGS7 | Signaling by GPCR |
| GO:0005096 | 0.00492038984684 | 0.8 | RGS6 RGS9 GNB5 RGS7 | GTPase activator activity |
| GO:0003924 | 0.0180995584082 | 0.8 | RGS6 RGS9 GNB5 RGS7 | GTPase activity |
| CORUM:7213 | 0.0498708842806 | 0.2 | GNB5 | GNAS-L-GNB5-GNG13 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GNB5 | RGS6 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GNB5 | RGS9 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRPF40B | RGS9 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RGS7 | GNB5 | 0.971 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GNB5 | PRPF40B | 0.89 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RGS7 | RGS6 | 0.214 |
mutually_exclusive (O14775)
|
bioplex3_WMM WMM_only |
Related Complexes