hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11523.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MTMR9 | Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9) | 5 | UniProt NCBI |
| MTMR7 | Myotubularin-related protein 7 (Inositol 1,3-bisphosphate phosphatase) (EC 3.1.3.-) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
| MTMR8 | Myotubularin-related protein 8 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
| MTMR6 | Myotubularin-related protein 6 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4971 | 2.67742980805e-09 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | Phosphoinositides metabolism |
| WP:WP5346 | 2.67742980805e-09 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | 8p23 1 copy number variation syndrome |
| REAC:R-HSA-1483255 | 9.87962469194e-08 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | PI Metabolism |
| GO:0046856 | 1.5748109659e-07 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | phosphatidylinositol dephosphorylation |
| GO:0046839 | 9.46202211089e-07 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | phospholipid dephosphorylation |
| REAC:R-HSA-1483257 | 3.70978327464e-06 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | Phospholipid metabolism |
| KEGG:00562 | 1.49470084516e-05 | 0.75 | MTMR6 MTMR7 MTMR8 | Inositol phosphate metabolism |
| REAC:R-HSA-1660499 | 2.27017011202e-05 | 0.75 | MTMR9 MTMR8 MTMR6 | Synthesis of PIPs at the plasma membrane |
| KEGG:04070 | 3.37636371132e-05 | 0.75 | MTMR6 MTMR7 MTMR8 | Phosphatidylinositol signaling system |
| GO:0004438 | 0.000109904886398 | 0.75 | MTMR6 MTMR7 MTMR8 | phosphatidylinositol-3-phosphate phosphatase activity |
| GO:0106018 | 0.000139871762976 | 0.75 | MTMR6 MTMR7 MTMR8 | phosphatidylinositol-3,5-bisphosphate phosphatase activity |
| GO:0052744 | 0.000139871762976 | 0.75 | MTMR6 MTMR7 MTMR8 | phosphatidylinositol monophosphate phosphatase activity |
| GO:0046488 | 0.000255005574346 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | phosphatidylinositol metabolic process |
| GO:0030258 | 0.000369531169251 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | lipid modification |
| REAC:R-HSA-556833 | 0.000555830316912 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | Metabolism of lipids |
| REAC:R-HSA-1660517 | 0.000563428413222 | 0.5 | MTMR9 MTMR7 | Synthesis of PIPs at the late endosome membrane |
| REAC:R-HSA-1855183 | 0.000676052383047 | 0.5 | MTMR9 MTMR7 | Synthesis of IP2, IP, and Ins in the cytosol |
| GO:0034593 | 0.000777349058504 | 0.75 | MTMR6 MTMR7 MTMR8 | phosphatidylinositol bisphosphate phosphatase activity |
| GO:0052866 | 0.00125794076491 | 0.75 | MTMR6 MTMR7 MTMR8 | phosphatidylinositol phosphate phosphatase activity |
| GO:0016311 | 0.00199346123908 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | dephosphorylation |
| WP:WP5411 | 0.002190823719 | 0.5 | MTMR8 MTMR6 | Phosphatidyl inositol phosphate pathway |
| GO:0006650 | 0.00325897222687 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | glycerophospholipid metabolic process |
| GO:0006644 | 0.00728390316897 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | phospholipid metabolic process |
| REAC:R-HSA-1483249 | 0.007571530532 | 0.5 | MTMR9 MTMR7 | Inositol phosphate metabolism |
| GO:0046486 | 0.00770077352423 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | glycerolipid metabolic process |
| REAC:R-HSA-1430728 | 0.0393174957935 | 1.0 | MTMR6 MTMR9 MTMR7 MTMR8 | Metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MTMR9 | MTMR6 | 1.0 | 0.582 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| MTMR9 | MTMR7 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MTMR7 | MTMR6 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MTMR9 | MTMR8 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MTMR7 | MTMR8 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MTMR6 | MTMR8 | 0.699 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| MTMR9 | huMAP3_01393.1 huMAP3_10161.1 huMAP3_11523.1 |
| MTMR7 | huMAP3_01393.1 huMAP3_10161.1 huMAP3_11523.1 |
| MTMR8 | huMAP3_02821.1 huMAP3_10161.1 huMAP3_11523.1 |
| MTMR6 | huMAP3_01393.1 huMAP3_10161.1 huMAP3_11523.1 |