hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11534.1
Complex Portal: CPX-23478
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPP1R14B | Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein) | 3 | UniProt NCBI |
| AARS1 | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42) | 5 | UniProt NCBI |
| ANKRD16 | Ankyrin repeat domain-containing protein 16 | 3 | UniProt NCBI |
| GARS1 | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | 5 | UniProt NCBI |
| PPA1 | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-379716 | 6.30285051125e-06 | 0.6 | AARS1 PPA1 GARS1 | Cytosolic tRNA aminoacylation |
| REAC:R-HSA-379724 | 3.5683276241e-05 | 0.6 | AARS1 PPA1 GARS1 | tRNA Aminoacylation |
| KEGG:00970 | 0.00408172507551 | 0.4 | AARS1 GARS1 | Aminoacyl-tRNA biosynthesis |
| REAC:R-HSA-72766 | 0.0119387407373 | 0.6 | AARS1 PPA1 GARS1 | Translation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PPA1 | GARS1 | 0.912 | 0.442 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| AARS1 | GARS1 | 0.888 | 0.272 | bioplex_WMM bioplex3_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM | |
| PPA1 | PPP1R14B | 0.878 | 0.178 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| AARS1 | ANKRD16 | 0.847 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPA1 | AARS1 | 0.825 | 0.324 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| AARS1 | PPP1R14B | 0.059 | 0.12 | bioplex_WMM bioplex3_WMM fraction | |
| PPP1R14B | GARS1 | 0.054 | 0.058 | bioplex_WMM bioplex3_WMM fraction | |
| ANKRD16 | GARS1 | 0.008 | 0.046 | bioplex3_HCT116 WMM_only | |
| PPA1 | ANKRD16 | 0.003 | 0.11 | bioplex3_HCT116 WMM_only |
Related Complexes