hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11548.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TCAIM | T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1) | 3 | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | 5 | UniProt NCBI |
| ARMS2 | Age-related maculopathy susceptibility protein 2 | 3 | UniProt NCBI |
| KGD4 | Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4) | 3 | UniProt NCBI |
| EXOC3L2 | Exocyst complex component 3-like protein 2 (HBV X-transactivated gene 7 protein) (HBV XAg-transactivated protein 7) | 3 | UniProt NCBI |
| PRR20C | Proline-rich protein 20C | 5 | UniProt NCBI |
| SIAH1 | E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a) | 5 | UniProt NCBI |
| PAGE2B | Putative G antigen family E member 3 (Prostate-associated gene 2B protein) (PAGE-2B) | 2 | UniProt NCBI |
| SLX4IP | Protein SLX4IP (SLX4-interacting protein) | 3 | UniProt NCBI |
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | 5 | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | 5 | UniProt NCBI |
| SIAH2 | E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) | 5 | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 1.49641459906e-10 | 0.416666666667 | OGDH DLD DLST OGDHL KGD4 | oxoglutarate dehydrogenase complex |
| GO:0045240 | 3.28685663218e-09 | 0.416666666667 | OGDH DLD DLST OGDHL KGD4 | dihydrolipoyl dehydrogenase complex |
| KEGG:00785 | 4.11766794219e-08 | 0.333333333333 | OGDH DLD OGDHL DLST | Lipoic acid metabolism |
| GO:0045239 | 4.39185568067e-08 | 0.416666666667 | OGDH DLD DLST OGDHL KGD4 | tricarboxylic acid cycle enzyme complex |
| CORUM:7267 | 1.02854698163e-07 | 0.25 | DLD OGDH DLST | KAT2A-Oxoglutarate dehydrogenase complex |
| KEGG:01210 | 3.66838312054e-07 | 0.333333333333 | OGDH DLD OGDHL DLST | 2-Oxocarboxylic acid metabolism |
| KEGG:00020 | 3.66838312054e-07 | 0.333333333333 | OGDH DLD OGDHL DLST | Citrate cycle (TCA cycle) |
| GO:0006103 | 9.27604366858e-06 | 0.333333333333 | OGDH DLST OGDHL KGD4 | 2-oxoglutarate metabolic process |
| REAC:R-HSA-71064 | 1.88928409724e-05 | 0.25 | DLD OGDH DLST | Lysine catabolism |
| GO:0004591 | 2.11464090368e-05 | 0.25 | OGDH OGDHL KGD4 | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| WP:WP2453 | 2.75024778999e-05 | 0.25 | DLD OGDH DLST | TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc |
| WP:WP78 | 4.00380105814e-05 | 0.25 | DLD OGDH DLST | TCA cycle aka Krebs or citric acid cycle |
| KEGG:01200 | 5.95814893286e-05 | 0.333333333333 | OGDH DLD OGDHL DLST | Carbon metabolism |
| GO:0106077 | 8.45465618902e-05 | 0.25 | DLD OGDH DLST | histone succinylation |
| GO:0018335 | 8.45465618902e-05 | 0.25 | DLD OGDH DLST | protein succinylation |
| GO:0006099 | 0.000137193142432 | 0.333333333333 | OGDH DLST OGDHL KGD4 | tricarboxylic acid cycle |
| REAC:R-HSA-71403 | 0.000151585507878 | 0.25 | DLD OGDH DLST | Citric acid cycle (TCA cycle) |
| REAC:R-HSA-389661 | 0.000261656080241 | 0.25 | DLD OGDH DLST | Glyoxylate metabolism and glycine degradation |
| WP:WP5352 | 0.000785011244429 | 0.25 | DLD OGDHL DLST | 10q11 21q11 23 copy number variation syndrome |
| GO:1990204 | 0.000916596208509 | 0.416666666667 | OGDH DLD DLST OGDHL KGD4 | oxidoreductase complex |
| GO:0016903 | 0.0011716924702 | 0.333333333333 | OGDH DLD OGDHL KGD4 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| GO:0016624 | 0.00118146610329 | 0.25 | OGDH OGDHL KGD4 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| REAC:R-HSA-71406 | 0.00248297703919 | 0.25 | DLD OGDH DLST | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP3925 | 0.00437471755022 | 0.25 | DLD OGDH DLST | Amino acid metabolism |
| WP:WP4932 | 0.00676210235326 | 0.25 | DLD OGDH DLST | 7q11 23 copy number variation syndrome |
| GO:0043648 | 0.00806066331254 | 0.333333333333 | OGDH DLST OGDHL KGD4 | dicarboxylic acid metabolic process |
| KEGG:00380 | 0.0167221426666 | 0.166666666667 | DLD DLST | Tryptophan metabolism |
| HPA:0570811 | 0.0347988370265 | 0.666666666667 | PAGE2B SIAH2 SIAH1 OGDHL DLST OGDH DLD KGD4 | testis; spermatogonia cells[>=Low] |
| HP:0012401 | 0.0499631138006 | 0.166666666667 | DLD OGDH | Abnormal urine alpha-ketoglutarate concentration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| SIAH1 | SIAH2 | 1.0 | |
| OGDH | DLST | 1.0 | 0.658 |
| OGDHL | DLD | 1.0 | 0.332 |
| OGDH | KGD4 | 0.999 | 0.512 |
| KGD4 | DLST | 0.999 | 0.336 |
| OGDHL | DLST | 0.999 | 0.74 |
| DLD | DLST | 0.998 | 0.736 |
| DLD | KGD4 | 0.998 | 0.346 |
| OGDHL | OGDH | 0.998 | 0.966 |
| OGDHL | KGD4 | 0.997 | 0.53 |
| DLD | OGDH | 0.995 | 0.478 |
| EXOC3L2 | SIAH1 | 0.994 | 0.084 |
| PRR20C | SIAH2 | 0.988 | |
| TCAIM | DLD | 0.985 | |
| OGDHL | PAGE2B | 0.981 | |
| SIAH1 | PRR20C | 0.981 | |
| SIAH1 | DLST | 0.979 | 0.068 |
| SIAH2 | DLD | 0.965 | |
| TCAIM | DLST | 0.965 | |
| SIAH1 | OGDHL | 0.965 | 0.078 |
| SIAH1 | KGD4 | 0.957 | 0.11 |
| OGDHL | TCAIM | 0.956 | |
| SIAH1 | OGDH | 0.942 | 0.118 |
| TCAIM | KGD4 | 0.936 | |
| TCAIM | OGDH | 0.934 | |
| SIAH2 | DLST | 0.9 | |
| OGDHL | SIAH2 | 0.897 | |
| DLD | SLX4IP | 0.892 | 0.206 |
| SIAH2 | OGDH | 0.817 | |
| OGDHL | ARMS2 | 0.811 | |
| SIAH2 | KGD4 | 0.752 | |
| PAGE2B | DLST | 0.704 | |
| SIAH1 | DLD | 0.657 | 0.0858235294118 |
| SIAH2 | TCAIM | 0.377 | |
| PAGE2B | DLD | 0.319 | |
| OGDHL | SLX4IP | 0.228 | 0.032 |
| SIAH1 | TCAIM | 0.224 | |
| TCAIM | SLX4IP | 0.188 | |
| SIAH2 | SLX4IP | 0.17 | |
| PAGE2B | KGD4 | 0.159 | |
| OGDH | ARMS2 | 0.13 | |
| DLST | SLX4IP | 0.129 | 0.08 |
| SIAH1 | SLX4IP | 0.128 | 0.102 |
| PAGE2B | OGDH | 0.11 | |
| DLD | ARMS2 | 0.099 | |
| KGD4 | ARMS2 | 0.074 | |
| DLST | ARMS2 | 0.072 | |
| PAGE2B | TCAIM | 0.055 | |
| OGDH | SLX4IP | 0.04 | 0.106 |
| KGD4 | SLX4IP | 0.031 | 0.074 |
| PRR20C | DLD | 0.017 | |
| PRR20C | DLST | 0.012 | |
| EXOC3L2 | DLD | 0.003 | 0.082 |
Related Complexes