hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11557.1
Complex Portal: CPX-24784
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LIX1L | LIX1-like protein | 2 | UniProt NCBI |
| CAPNS2 | Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) | 5 | UniProt NCBI |
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | 4 | UniProt NCBI |
| CAPN2 | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | 5 | UniProt NCBI |
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | 5 | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | 5 | UniProt NCBI |
| WNT8B | Protein Wnt-8b | 5 | UniProt NCBI |
| CAST | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8862803 | 2.13041126881e-08 | 0.571428571429 | CAST CAPN1 CAPNS2 CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 2.13041126881e-08 | 0.571428571429 | CAST CAPN1 CAPNS2 CAPNS1 | Neurodegenerative Diseases |
| REAC:R-HSA-9734009 | 3.78054911863e-08 | 0.571428571429 | CAST CAPN1 CAPNS2 CAPNS1 | Defective Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-1474228 | 6.99658095042e-08 | 0.714285714286 | CAST CAPN8 CAPNS2 CAPNS1 CAPN1 | Degradation of the extracellular matrix |
| GO:0004198 | 3.03561565333e-07 | 0.571428571429 | CAPN8 CAPNS2 CAPNS1 CAPN1 | calcium-dependent cysteine-type endopeptidase activity |
| REAC:R-HSA-1474244 | 3.50957983152e-06 | 0.714285714286 | CAST CAPN8 CAPNS2 CAPNS1 CAPN1 | Extracellular matrix organization |
| REAC:R-HSA-9645723 | 9.40454269709e-06 | 0.571428571429 | CAST CAPN1 CAPNS2 CAPNS1 | Diseases of programmed cell death |
| GO:0110158 | 1.34540429244e-05 | 0.428571428571 | CAPN1 CAPNS2 CAPNS1 | calpain complex |
| CORUM:6710 | 2.05265451394e-05 | 0.285714285714 | CAPN1 CAPNS1 | Calpain 1 |
| GO:0008303 | 0.000282244947588 | 0.428571428571 | CAPN1 CAPNS2 CAPNS1 | caspase complex |
| GO:0004197 | 0.000835286748042 | 0.571428571429 | CAPN8 CAPNS2 CAPNS1 CAPN1 | cysteine-type endopeptidase activity |
| KEGG:05131 | 0.00645082416518 | 0.428571428571 | CAPN1 CAST CAPNS1 | Shigellosis |
| GO:0008234 | 0.00767441269742 | 0.571428571429 | CAPN8 CAPNS2 CAPNS1 CAPN1 | cysteine-type peptidase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAST | CAPN1 | 1.0 | 0.144 |
mutually_exclusive (P17655)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| CAPN1 | CAPNS1 | 1.0 | 0.604 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| LIX1L | CAPNS2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAST | CAPN8 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CAPN1 | CAPNS2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CAST | CAPNS1 | 0.997 | 0.186 |
mutually_exclusive (P17655)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CAPN8 | CAPN1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CAST | CAPNS2 | 0.991 |
mutually_exclusive (P17655)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPN2 | CAPNS1 | 0.987 | 0.336 |
mutually_exclusive (Q96L46)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CAPN8 | CAPNS1 | 0.972 |
mutually_exclusive (Q96L46)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPN2 | CAPN1 | 0.963 | 0.16 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| CAST | LIX1L | 0.959 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| CAPNS1 | CAPNS2 | 0.888 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPNS2 | WNT8B | 0.885 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CAST | CAPN2 | 0.707 | 0.142 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| LIX1L | CAPNS1 | 0.641 | 0.038 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LIX1L | CAPN1 | 0.577 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only | |
| CAPN8 | CAPN2 | 0.56 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CAPN2 | CAPNS2 | 0.55 |
mutually_exclusive (P04632)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LIX1L | CAPN2 | 0.101 | 0.094 |
mutually_exclusive (Q96L46)
|
bioplex_WMM bioplex3_WMM WMM_only |
| CAPN1 | WNT8B | 0.059 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes