hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11576.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
DUS2	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2)	5	UniProt NCBI
PHF20L1	PHD finger protein 20-like protein 1	5	UniProt NCBI
KANSL3	KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD)	5	UniProt NCBI
MSL2	E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.-) (E3 ubiquitin-protein transferase MSL2) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184)	5	UniProt NCBI
KAT8	Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF)	5	UniProt NCBI
KANSL2	KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog)	5	UniProt NCBI
KANSL1L	KAT8 regulatory NSL complex subunit 1-like protein (MSL1v2)	3	UniProt NCBI
MSL3	Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1)	5	UniProt NCBI
MCRS1	Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2)	5	UniProt NCBI
PHF20	PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP)	5	UniProt NCBI
KANSL1	KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog)	5	UniProt NCBI
MSL1	Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1)	5	UniProt NCBI
C9JHY2		None	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:1902562	1.58055478552e-23	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	H4 histone acetyltransferase complex
GO:0044545	7.91961549209e-20	0.666666666667	KANSL1L KANSL2 KAT8 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	NSL complex
GO:0000123	1.17837120085e-19	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	histone acetyltransferase complex
GO:1902493	4.12257662719e-19	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	acetyltransferase complex
GO:0031248	4.12257662719e-19	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	protein acetyltransferase complex
CORUM:7221	3.48799657511e-16	0.5	KANSL2 KAT8 MCRS1 PHF20 KANSL3 KANSL1	NSL complex
REAC:R-HSA-3214847	1.43265604746e-14	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	HATs acetylate histones
REAC:R-HSA-9772755	1.40790182527e-13	0.583333333333	KANSL2 KAT8 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	Formation of WDR5-containing histone-modifying complexes
REAC:R-HSA-4839726	6.21104791502e-12	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	Chromatin organization
REAC:R-HSA-3247509	6.21104791502e-12	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	Chromatin modifying enzymes
CORUM:7220	1.58451975055e-11	0.333333333333	MSL1 MSL3 MSL2 KAT8	MSL complex
CORUM:610	1.58451975055e-11	0.333333333333	KANSL1 MSL3 MSL2 KAT8	MSL complex
GO:1990234	5.1209373747e-09	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	transferase complex
REAC:R-HSA-212165	5.43784439944e-09	0.583333333333	KANSL2 KAT8 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	Epigenetic regulation of gene expression
GO:0140535	9.65007281378e-09	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	intracellular protein-containing complex
GO:0000785	6.02066598012e-08	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	chromatin
GO:0072487	6.50952358374e-08	0.333333333333	MSL1 MSL3 MSL2 KAT8	MSL complex
GO:0032993	1.15043525895e-07	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	protein-DNA complex
CORUM:5386	2.34612483517e-07	0.333333333333	PHF20 KANSL1 KAT8 MCRS1	MLL1-WDR5 complex
GO:0005694	3.2172928117e-06	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	chromosome
GO:1902494	8.57493687429e-06	0.916666666667	KANSL1L KANSL2 MSL1 MSL3 KAT8 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	catalytic complex
GO:0071339	0.000405002050765	0.333333333333	PHF20 KANSL1 KAT8 MCRS1	MLL1 complex
GO:0045893	0.000449136406709	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	positive regulation of DNA-templated transcription
GO:1902680	0.000460579767212	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	positive regulation of RNA biosynthetic process
GO:0044665	0.000462656529812	0.333333333333	PHF20 KANSL1 KAT8 MCRS1	MLL1/2 complex
GO:0051254	0.00122729510908	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	positive regulation of RNA metabolic process
GO:0045935	0.00392911460506	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	positive regulation of nucleobase-containing compound metabolic process
REAC:R-HSA-74160	0.00615586937905	0.583333333333	KANSL2 KAT8 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	Gene expression (Transcription)
GO:0035097	0.00806066331254	0.333333333333	PHF20 KANSL1 KAT8 MCRS1	histone methyltransferase complex
GO:0006355	0.0231954695221	0.833333333333	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	regulation of DNA-templated transcription
GO:2001141	0.024593100625	0.833333333333	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	regulation of RNA biosynthetic process
GO:0010557	0.0257971861009	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	positive regulation of macromolecule biosynthetic process
GO:0016070	0.0295140519053	0.916666666667	DUS2 KANSL2 MSL1 MSL3 KAT8 KANSL3 MCRS1 PHF20 PHF20L1 MSL2 KANSL1	RNA metabolic process
GO:0031328	0.0333237547711	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	positive regulation of cellular biosynthetic process
GO:0034708	0.0335068326819	0.333333333333	PHF20 KANSL1 KAT8 MCRS1	methyltransferase complex
GO:0009891	0.0352175466622	0.75	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 KANSL3 KANSL1	positive regulation of biosynthetic process
GO:0006351	0.0366718397404	0.833333333333	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	DNA-templated transcription
GO:0032774	0.0406573052331	0.833333333333	KANSL2 MSL1 KAT8 MSL3 MSL2 MCRS1 PHF20 PHF20L1 KANSL3 KANSL1	RNA biosynthetic process

Edges

Protein 1	Protein 2	Score	ProteomeHD
PHF20	KANSL3	1.0	0.286
PHF20	KANSL1	0.999	0.41
MSL2	KAT8	0.999	0.146
PHF20L1	KANSL1	0.999	0.19
KANSL2	KANSL1	0.999	0.492
MSL1	KAT8	0.999	0.39
MSL2	MSL3	0.998	0.216
KAT8	KANSL3	0.998	0.18
MCRS1	KANSL1	0.997	0.482
PHF20L1	KANSL3	0.997	0.204
PHF20L1	KAT8	0.997	0.146
PHF20L1	MCRS1	0.997	0.314
PHF20L1	KANSL2	0.997	0.164
MSL1	MSL2	0.996	0.32
KANSL2	PHF20	0.995	0.316
KANSL1	DUS2	0.995	0.046
KANSL1	KAT8	0.994	0.192
MCRS1	PHF20	0.992	0.374
KANSL1	KANSL3	0.991	0.348
MCRS1	KAT8	0.99	0.584
MSL1	MSL3	0.99	0.242
PHF20	KAT8	0.99	0.266
MCRS1	KANSL2	0.99	0.676
KANSL2	KANSL3	0.988	0.534
KANSL1L	PHF20L1	0.984
KANSL3	C9JHY2	0.977
MCRS1	KANSL3	0.954	0.332
PHF20L1	C9JHY2	0.903
KAT8	C9JHY2	0.901
KANSL1	C9JHY2	0.897
MCRS1	MSL1	0.896	0.486
KANSL2	C9JHY2	0.88
KAT8	MSL3	0.855	0.17
MCRS1	C9JHY2	0.841
KANSL2	KAT8	0.78	0.278
PHF20L1	DUS2	0.572	0.07
PHF20	DUS2	0.572	0.07
MCRS1	MSL3	0.423	0.248
KANSL1L	KANSL3	0.415
KANSL1L	KANSL1	0.415
KANSL1L	C9JHY2	0.415
KANSL1L	KAT8	0.415
KANSL2	DUS2	0.303	0.122
PHF20L1	PHF20	0.265	0.236
MSL2	KANSL1	0.248	0.242
KANSL1	MSL3	0.248	0.18
PHF20	C9JHY2	0.245
MSL2	KANSL3	0.232	0.232
KANSL1L	KANSL2	0.21
MCRS1	MSL2	0.192	0.358
MSL1	KANSL1	0.192	0.394
KANSL3	MSL3	0.192	0.128
MCRS1	DUS2	0.143	0.076
KANSL2	MSL1	0.089	0.472
KANSL1L	MCRS1	0.078
MSL1	KANSL3	0.063	0.25

Related Complexes

Genename	Complexes
DUS2	huMAP3_03399.1 huMAP3_03971.1 huMAP3_04875.1 huMAP3_07062.1 huMAP3_10027.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
PHF20L1	huMAP3_00594.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
KANSL3	huMAP3_04283.1 huMAP3_08515.1 huMAP3_10050.1 huMAP3_10106.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
MSL2	huMAP3_03334.1 huMAP3_03404.1 huMAP3_05936.1 huMAP3_06991.1 huMAP3_08116.1 huMAP3_11576.1 huMAP3_12676.1
KAT8	huMAP3_03404.1 huMAP3_03971.1 huMAP3_05936.1 huMAP3_07062.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
KANSL2	huMAP3_02631.1 huMAP3_06050.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
KANSL1L	huMAP3_00594.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
MSL3	huMAP3_05936.1 huMAP3_08116.1 huMAP3_11576.1 huMAP3_11792.1 huMAP3_12676.1 huMAP3_15215.1
MCRS1	huMAP3_01995.1 huMAP3_03971.1 huMAP3_06050.1 huMAP3_08515.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_14133.1 huMAP3_14284.1
PHF20	huMAP3_03399.1 huMAP3_03971.1 huMAP3_07062.1 huMAP3_08515.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
KANSL1	huMAP3_03399.1 huMAP3_03971.1 huMAP3_04875.1 huMAP3_07062.1 huMAP3_10027.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
MSL1	huMAP3_03334.1 huMAP3_03404.1 huMAP3_05936.1 huMAP3_08116.1 huMAP3_11576.1 huMAP3_12676.1
C9JHY2	huMAP3_04283.1 huMAP3_08515.1 huMAP3_10050.1 huMAP3_10106.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11576.1