hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11592.1
Complex Portal: CPX-16743
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WNK3 | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | 5 | UniProt NCBI |
| UCK1 | Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) | 5 | UniProt NCBI |
| KLHL2 | Kelch-like protein 2 (Actin-binding protein Mayven) | 5 | UniProt NCBI |
| UCKL1 | Uridine-cytidine kinase-like 1 (EC 2.7.1.48) | 5 | UniProt NCBI |
| UPRT | Uracil phosphoribosyltransferase homolog | 5 | UniProt NCBI |
| TRIM8 | E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-73614 | 0.0014177632075 | 0.333333333333 | UCK1 UCKL1 | Pyrimidine salvage |
| REAC:R-HSA-8956321 | 0.00540340354533 | 0.333333333333 | UCK1 UCKL1 | Nucleotide salvage |
| KEGG:00240 | 0.0071411999113 | 0.333333333333 | UCK1 UCKL1 | Pyrimidine metabolism |
| KEGG:00983 | 0.0158846761267 | 0.333333333333 | UCK1 UCKL1 | Drug metabolism - other enzymes |
| KEGG:01232 | 0.0173407760832 | 0.333333333333 | UCK1 UCKL1 | Nucleotide metabolism |
| GO:0004849 | 0.042122686785 | 0.333333333333 | UCK1 UCKL1 | uridine kinase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UPRT | UCKL1 | 1.0 | 0.216 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UPRT | UCK1 | 0.999 | 0.082 |
structurally_consistent (Q9NWZ5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UCKL1 | UCK1 | 0.993 | 0.15 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| KLHL2 | TRIM8 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KLHL2 | UCK1 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| WNK3 | KLHL2 | 0.965 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KLHL2 | UCKL1 | 0.954 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KLHL2 | UPRT | 0.921 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TRIM8 | UCK1 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WNK3 | UCKL1 | 0.486 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| WNK3 | TRIM8 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TRIM8 | UPRT | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TRIM8 | UCKL1 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WNK3 | UCK1 | 0.172 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| WNK3 | UPRT | 0.164 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes