hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11597.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPC1 | Glypican-1 [Cleaved into: Secreted glypican-1] | 5 | UniProt NCBI |
| GPC6 | Glypican-6 [Cleaved into: Secreted glypican-6] | 5 | UniProt NCBI |
| CEACAM7 | Carcinoembryonic antigen-related cell adhesion molecule 7 (CEA cell adhesion molecule 7) (Carcinoembryonic antigen CGM2) | 5 | UniProt NCBI |
| GPC4 | Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4] | 5 | UniProt NCBI |
| LRRTM3 | Leucine-rich repeat transmembrane neuronal protein 3 | 5 | UniProt NCBI |
| GPC3 | Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit] | 5 | UniProt NCBI |
| HBEGF | Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)] | 5 | UniProt NCBI |
| USP3 | Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656237 | 7.82847303023e-09 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-3656253 | 7.82847303023e-09 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-9694614 | 1.86009193219e-08 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Attachment and Entry |
| REAC:R-HSA-4420332 | 2.39102266359e-08 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560783 | 2.39102266359e-08 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-3560801 | 2.39102266359e-08 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-2024096 | 5.71078496603e-08 | 0.5 | GPC3 GPC4 GPC1 GPC6 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 8.29203003935e-08 | 0.5 | GPC3 GPC4 GPC1 GPC6 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 1.59637187216e-07 | 0.5 | GPC3 GPC4 GPC1 GPC6 | HS-GAG biosynthesis |
| REAC:R-HSA-9772572 | 3.18690821415e-07 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Early SARS-CoV-2 Infection Events |
| REAC:R-HSA-3560782 | 5.74251600696e-07 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 7.10666264099e-07 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 9.59028444154e-07 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 1.26728835517e-06 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1638091 | 1.78693125766e-06 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Heparan sulfate/heparin (HS-GAG) metabolism |
| REAC:R-HSA-2187338 | 1.09999749188e-05 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Visual phototransduction |
| REAC:R-HSA-1630316 | 4.42080215782e-05 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Glycosaminoglycan metabolism |
| REAC:R-HSA-3781865 | 4.75382642053e-05 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Diseases of glycosylation |
| REAC:R-HSA-196854 | 0.000184608764319 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Metabolism of vitamins and cofactors |
| HP:5201010 | 0.000226027933833 | 0.25 | GPC4 GPC3 | Microform cleft of the upper lip |
| HP:0006176 | 0.000226027933833 | 0.25 | GPC4 GPC3 | Two carpal ossification centers present at birth |
| HP:0009101 | 0.000226027933833 | 0.25 | GPC4 GPC3 | Submucous cleft lip |
| REAC:R-HSA-5668914 | 0.00037140085884 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Diseases of metabolism |
| REAC:R-HSA-9709957 | 0.000567724058779 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Sensory Perception |
| HP:0004464 | 0.000677898190386 | 0.25 | GPC4 GPC3 | Postauricular pit |
| HP:0008416 | 0.000677898190386 | 0.25 | GPC4 GPC3 | Six lumbar vertebrae |
| REAC:R-HSA-71387 | 0.00129598700925 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Metabolism of carbohydrates |
| HP:0005580 | 0.00135542525381 | 0.25 | GPC4 GPC3 | Duplication of renal pelvis |
| HP:0003185 | 0.00135542525381 | 0.25 | GPC4 GPC3 | Short greater sciatic notch |
| HP:0002711 | 0.00135542525381 | 0.25 | GPC4 GPC3 | Exaggerated median tongue furrow |
| REAC:R-HSA-9694516 | 0.00167221986087 | 0.5 | GPC3 GPC4 GPC1 GPC6 | SARS-CoV-2 Infection |
| HP:0009908 | 0.00225842370351 | 0.25 | GPC4 GPC3 | Anterior creases of earlobe |
| HP:0002946 | 0.00225842370351 | 0.25 | GPC4 GPC3 | Supernumerary vertebrae |
| HP:0003517 | 0.00225842370351 | 0.25 | GPC4 GPC3 | Birth length greater than 97th percentile |
| HP:0030304 | 0.00225842370351 | 0.25 | GPC4 GPC3 | Abnormal number of vertebrae |
| GO:0005796 | 0.002326053637 | 0.5 | GPC3 GPC4 GPC1 GPC6 | Golgi lumen |
| GO:0009986 | 0.00259800019368 | 0.75 | GPC3 HBEGF CEACAM7 GPC1 GPC6 GPC4 | cell surface |
| HP:0008523 | 0.00338670821406 | 0.25 | GPC4 GPC3 | Posterior helix pit |
| GO:0043202 | 0.00349206859402 | 0.5 | GPC3 GPC4 GPC1 GPC6 | lysosomal lumen |
| KEGG:05205 | 0.0050295788442 | 0.375 | GPC3 GPC1 HBEGF | Proteoglycans in cancer |
| REAC:R-HSA-9679506 | 0.00591668210798 | 0.5 | GPC3 GPC4 GPC1 GPC6 | SARS-CoV Infections |
| REAC:R-HSA-5663205 | 0.00732097255999 | 0.625 | GPC3 GPC4 GPC1 HBEGF GPC6 | Infectious disease |
| HP:0001233 | 0.0101490036868 | 0.25 | GPC4 GPC3 | 2-3 finger syndactyly |
| HP:0001799 | 0.0124009419501 | 0.25 | GPC4 GPC3 | Short nail |
| HP:0005160 | 0.014877056319 | 0.25 | GPC4 GPC3 | Total anomalous pulmonary venous return |
| HP:0000891 | 0.014877056319 | 0.25 | GPC4 GPC3 | Cervical ribs |
| HP:0004510 | 0.014877056319 | 0.25 | GPC4 GPC3 | Pancreatic islet-cell hyperplasia |
| HP:0009536 | 0.014877056319 | 0.25 | GPC4 GPC3 | Short 2nd finger |
| HP:0000879 | 0.0175771621337 | 0.25 | GPC4 GPC3 | Short sternum |
| GO:1905475 | 0.0179481315058 | 0.5 | GPC3 GPC4 GPC1 GPC6 | regulation of protein localization to membrane |
| HP:0006264 | 0.020501074829 | 0.25 | GPC4 GPC3 | Aplasia/Hypoplasia of the 2nd finger |
| HP:0002869 | 0.0306138099712 | 0.25 | GPC4 GPC3 | Flared iliac wing |
| HP:0005622 | 0.0306789550085 | 0.375 | GPC4 GPC6 GPC3 | Broad long bones |
| HP:0006714 | 0.0344311064357 | 0.25 | GPC4 GPC3 | Aplasia/Hypoplasia of the sternum |
| HP:0003375 | 0.0384712883781 | 0.25 | GPC4 GPC3 | Narrow greater sciatic notch |
| HP:0010456 | 0.0427341718023 | 0.25 | GPC4 GPC3 | Abnormal greater sciatic notch morphology |
| GO:0005775 | 0.0433830596151 | 0.5 | GPC3 GPC4 GPC1 GPC6 | vacuolar lumen |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GPC4 | GPC1 | 0.99 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| HBEGF | GPC1 | 0.986 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPC1 | CEACAM7 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPC4 | HBEGF | 0.973 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPC6 | GPC4 | 0.97 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GPC1 | GPC3 | 0.948 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP3 | GPC1 | 0.94 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GPC4 | GPC3 | 0.916 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LRRTM3 | GPC3 | 0.912 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| LRRTM3 | GPC4 | 0.885 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| LRRTM3 | GPC1 | 0.78 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GPC6 | GPC3 | 0.498 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPC6 | GPC1 | 0.347 | 0.228 | bioplex_WMM bioplex3_WMM WMM_only |
| LRRTM3 | GPC6 | 0.141 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| USP3 | GPC3 | 0.02 | bioplex_WMM WMM_only | |
| GPC4 | USP3 | 0.009 | 0.082 | bioplex_WMM WMM_only |
Related Complexes