hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11599.1
Complex Portal: CPX-24587
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRMP1 | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | 5 | UniProt NCBI |
| DPYSL3 | Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) | 5 | UniProt NCBI |
| SLC12A5 | Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter) | 5 | UniProt NCBI |
| TTLL6 | Tubulin polyglutamylase TTLL6 (EC 6.3.2.-) (Protein polyglutamylase TTLL6) (Tubulin--tyrosine ligase-like protein 6) | 5 | UniProt NCBI |
| DPYSL2 | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | 5 | UniProt NCBI |
| DPYS | Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase) | 5 | UniProt NCBI |
| DPYSL4 | Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) | 5 | UniProt NCBI |
| DPYSL5 | Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016812 | 9.56047657747e-14 | 0.75 | DPYSL4 DPYSL3 DPYS DPYSL5 DPYSL2 CRMP1 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| REAC:R-HSA-399956 | 6.43259852157e-12 | 0.625 | DPYSL5 DPYSL4 CRMP1 DPYSL2 DPYSL3 | CRMPs in Sema3A signaling |
| REAC:R-HSA-373755 | 1.06433850395e-08 | 0.625 | DPYSL5 DPYSL4 CRMP1 DPYSL2 DPYSL3 | Semaphorin interactions |
| GO:0016810 | 1.07816014704e-07 | 0.75 | DPYSL4 DPYSL3 DPYS DPYSL5 DPYSL2 CRMP1 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| REAC:R-HSA-422475 | 0.000419447735437 | 0.625 | DPYSL5 DPYSL4 CRMP1 DPYSL2 DPYSL3 | Axon guidance |
| GO:0031005 | 0.00045145282213 | 0.375 | DPYSL4 CRMP1 DPYSL3 | filamin binding |
| REAC:R-HSA-9675108 | 0.000502626611933 | 0.625 | DPYSL5 DPYSL4 CRMP1 DPYSL2 DPYSL3 | Nervous system development |
| REAC:R-HSA-1266738 | 0.00691845604305 | 0.625 | DPYSL5 DPYSL4 CRMP1 DPYSL2 DPYSL3 | Developmental Biology |
| GO:0004157 | 0.0131096201623 | 0.25 | DPYS DPYSL2 | dihydropyrimidinase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DPYSL4 | DPYSL5 | 1.0 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| DPYSL2 | DPYSL5 | 1.0 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| DPYSL3 | DPYSL4 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | ||
| DPYS | DPYSL5 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| DPYSL3 | DPYSL2 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| CRMP1 | DPYSL3 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | ||
| DPYSL3 | DPYSL5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | ||
| DPYSL2 | DPYSL4 | 0.999 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| DPYSL3 | DPYS | 0.999 |
mutually_exclusive (Q16555)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DPYSL2 | DPYS | 0.997 |
mutually_exclusive (Q14195)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CRMP1 | DPYSL4 | 0.967 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| CRMP1 | DPYSL5 | 0.954 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| CRMP1 | DPYSL2 | 0.93 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | ||
| CRMP1 | TTLL6 | 0.89 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CRMP1 | SLC12A5 | 0.862 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DPYSL3 | SLC12A5 | 0.845 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DPYSL2 | SLC12A5 | 0.845 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| DPYSL5 | SLC12A5 | 0.734 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| DPYS | DPYSL4 | 0.71 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DPYSL3 | TTLL6 | 0.517 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CRMP1 | DPYS | 0.364 | bioplex3_WMM WMM_only | ||
| DPYSL4 | SLC12A5 | 0.05 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes