hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11602.1

Complex Portal: CPX-18950

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
UTY	Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY)	5	UniProt NCBI
SETD1B	Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)	5	UniProt NCBI
ZXDC	Zinc finger protein ZXDC (ZXD-like zinc finger protein)	5	UniProt NCBI
KMT2D	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	5	UniProt NCBI
HCFC2	Host cell factor 2 (HCF-2) (C2 factor)	5	UniProt NCBI
HCFC1	Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]	5	UniProt NCBI
DPY30	Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)	5	UniProt NCBI
SETD1A	Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)	5	UniProt NCBI
NCOA6	Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)	5	UniProt NCBI
C21orf58	Uncharacterized protein C21orf58	2	UniProt NCBI
KDM6A	Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)	5	UniProt NCBI
KMT2B	Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)	5	UniProt NCBI
MEN1	Menin	5	UniProt NCBI
AK7	Adenylate kinase 7 (AK 7) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 7)	5	UniProt NCBI
BOD1L1	Biorientation of chromosomes in cell division protein 1-like 1	5	UniProt NCBI
KMT2A	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	5	UniProt NCBI
PAGR1	PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1)	5	UniProt NCBI
CXXC1	CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)	5	UniProt NCBI
RBBP5	Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)	5	UniProt NCBI
KMT2C	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)	5	UniProt NCBI
WDR5	WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)	5	UniProt NCBI
PAXIP1	PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)	5	UniProt NCBI
BOD1	Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B)	5	UniProt NCBI
ASH2L	Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)	5	UniProt NCBI
ATN1	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9772755	2.94540825343e-47	0.8	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 PAXIP1 HCFC2 KMT2C PAGR1 NCOA6 KMT2B KMT2A DPY30 SETD1A RBBP5 KDM6A SETD1B KMT2D BOD1L1	Formation of WDR5-containing histone-modifying complexes
GO:0035097	4.61217351719e-43	0.84	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 NCOA6 KMT2B KMT2D PAXIP1 DPY30 SETD1A RBBP5 KDM6A SETD1B UTY BOD1L1	histone methyltransferase complex
GO:0034708	2.4610935498e-39	0.84	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 NCOA6 KMT2B KMT2D PAXIP1 DPY30 SETD1A RBBP5 KDM6A SETD1B UTY BOD1L1	methyltransferase complex
REAC:R-HSA-212165	1.21022111298e-32	0.8	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 PAXIP1 HCFC2 KMT2C PAGR1 NCOA6 KMT2B KMT2A DPY30 SETD1A RBBP5 KDM6A SETD1B KMT2D BOD1L1	Epigenetic regulation of gene expression
CORUM:5195	1.05356576255e-27	0.4	ASH2L PAXIP1 WDR5 KMT2B NCOA6 KMT2C DPY30 RBBP5 KDM6A PAGR1	PTIP-HMT complex
GO:0044666	1.37421621202e-27	0.44	PAXIP1 WDR5 ASH2L KMT2C NCOA6 KMT2D DPY30 RBBP5 KDM6A PAGR1 UTY	MLL3/4 complex
CORUM:6470	6.94055501789e-26	0.4	BOD1 HCFC1 WDR5 HCFC2 DPY30 BOD1L1 ASH2L SETD1B CXXC1 RBBP5	Set1B complex
GO:0048188	4.9889708651e-25	0.44	BOD1 HCFC1 WDR5 HCFC2 DPY30 BOD1L1 RBBP5 ASH2L SETD1B CXXC1 SETD1A	Set1C/COMPASS complex
CORUM:6467	9.61773845486e-25	0.36	WDR5 ASH2L NCOA6 PAXIP1 DPY30 RBBP5 KDM6A PAGR1 KMT2D	MLL4 complex
CORUM:6461	9.61773845486e-25	0.36	PAXIP1 WDR5 ASH2L KMT2C NCOA6 DPY30 RBBP5 KDM6A PAGR1	MLL3 complex
CORUM:6469	3.71106475058e-20	0.32	HCFC1 WDR5 HCFC2 DPY30 SETD1A ASH2L CXXC1 RBBP5	Set1A complex
CORUM:6460	3.71106475058e-20	0.32	WDR5 HCFC1 DPY30 HCFC2 MEN1 RBBP5 ASH2L KMT2D	MLL2 complex
CORUM:3075	4.07372846082e-19	0.32	PAXIP1 ASH2L KMT2C NCOA6 WDR5 RBBP5 KDM6A KMT2D	UTX-MLL2/3 complex
GO:1990234	6.90012888494e-19	0.84	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 NCOA6 KMT2B KMT2D PAXIP1 DPY30 SETD1A RBBP5 KDM6A SETD1B UTY BOD1L1	transferase complex
CORUM:6462	5.35950664847e-18	0.28	MEN1 HCFC1 WDR5 ASH2L DPY30 RBBP5 KMT2A	MLL1 complex
WP:WP5351	2.90406233925e-17	0.36	PAXIP1 WDR5 ASH2L KMT2C NCOA6 DPY30 RBBP5 KDM6A PAGR1	Kleefstra syndrome
GO:0140513	1.13384972021e-15	0.84	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 NCOA6 KMT2B KMT2D PAXIP1 DPY30 SETD1A RBBP5 KDM6A SETD1B UTY BOD1L1	nuclear protein-containing complex
REAC:R-HSA-3214841	2.39277316092e-15	0.4	WDR5 KMT2B KMT2C KMT2D DPY30 SETD1A ASH2L SETD1B KMT2A RBBP5	PKMTs methylate histone lysines
CORUM:1256	3.60565229633e-15	0.24	HCFC1 MEN1 ASH2L WDR5 RBBP5 KMT2A	MLL-HCF complex
CORUM:1254	3.60565229633e-15	0.24	DPY30 ASH2L WDR5 RBBP5 KMT2B MEN1	Menin-associated histone methyltransferase complex
REAC:R-HSA-74160	8.96276876682e-15	0.8	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 PAXIP1 HCFC2 KMT2C PAGR1 NCOA6 KMT2B KMT2A DPY30 SETD1A RBBP5 KDM6A SETD1B KMT2D BOD1L1	Gene expression (Transcription)
REAC:R-HSA-4839726	1.10580703006e-14	0.52	ASH2L HCFC1 WDR5 KMT2A KMT2B KMT2C KMT2D DPY30 SETD1A KDM6A SETD1B UTY RBBP5	Chromatin organization
REAC:R-HSA-3247509	1.10580703006e-14	0.52	ASH2L HCFC1 WDR5 KMT2A KMT2B KMT2C KMT2D DPY30 SETD1A KDM6A SETD1B UTY RBBP5	Chromatin modifying enzymes
REAC:R-HSA-8936459	1.33983922752e-14	0.4	WDR5 KMT2B KMT2C KMT2D DPY30 SETD1A ASH2L SETD1B KMT2A RBBP5	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
GO:0044665	3.34913418491e-14	0.36	WDR5 HCFC1 DPY30 HCFC2 MEN1 RBBP5 KMT2B ASH2L KMT2A	MLL1/2 complex
REAC:R-HSA-5619507	2.52961586365e-13	0.4	PAXIP1 WDR5 ASH2L NCOA6 KMT2C DPY30 RBBP5 KDM6A PAGR1 KMT2D	Activation of HOX genes during differentiation
REAC:R-HSA-5617472	2.52961586365e-13	0.4	PAXIP1 WDR5 ASH2L NCOA6 KMT2C DPY30 RBBP5 KDM6A PAGR1 KMT2D	Activation of anterior HOX genes in hindbrain development during early embryogenesis
CORUM:6851	3.76695501641e-13	0.2	WDR5 DPY30 ASH2L KMT2A RBBP5	MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30)
GO:1902494	9.39596841762e-13	0.84	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 NCOA6 KMT2B KMT2D PAXIP1 DPY30 SETD1A RBBP5 KDM6A SETD1B UTY BOD1L1	catalytic complex
CORUM:2730	2.25759466966e-12	0.2	WDR5 SETD1B ASH2L CXXC1 RBBP5	Set1B complex
CORUM:2731	2.25759466966e-12	0.2	WDR5 ASH2L SETD1A RBBP5 CXXC1	Set1A complex
CORUM:1400	7.89256721305e-12	0.2	ASH2L KMT2C KMT2D RBBP5 NCOA6	ASCOM complex
GO:0071339	8.08446377659e-12	0.32	WDR5 HCFC1 DPY30 HCFC2 MEN1 RBBP5 ASH2L KMT2A	MLL1 complex
CORUM:1401	9.43870208634e-11	0.2	KMT2A WDR5 KMT2D RBBP5 SETD1A	MOF complex
CORUM:6457	2.62090379737e-10	0.16	WDR5 ASH2L KMT2A RBBP5	MLL1 core complex
CORUM:6849	2.62090379737e-10	0.16	DPY30 ASH2L RBBP5 WDR5	WRAD complex (WDR5, RBBP5, ASH2L, DPY30)
CORUM:1399	2.62090379737e-10	0.16	WDR5 ASH2L KMT2D RBBP5	WDR5-ASH2L-RBBP5-MLL2 complex
REAC:R-HSA-8878171	2.79234740194e-10	0.4	WDR5 KMT2B KMT2C KMT2D DPY30 SETD1A ASH2L SETD1B KMT2A RBBP5	Transcriptional regulation by RUNX1
GO:0042800	3.00880252119e-10	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	histone H3K4 methyltransferase activity
CORUM:6340	1.30894511668e-09	0.16	PAXIP1 ASH2L KMT2D RBBP5	PITX2-MLL4-ASH2L-RBBP5-PTIP complex
CORUM:5386	2.41919912754e-08	0.2	WDR5 ASH2L HCFC1 RBBP5 KMT2A	MLL1-WDR5 complex
KEGG:00310	3.23154997611e-08	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	Lysine degradation
WP:WP2369	9.15724431371e-08	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	Histone modifications
GO:0006325	1.29339355838e-07	0.48	WDR5 HCFC1 MEN1 HCFC2 PAXIP1 KMT2A DPY30 SETD1A ASH2L KDM6A KMT2D RBBP5	chromatin organization
CORUM:7367	1.74075664942e-07	0.12	WDR5 RBBP5 ASH2L	ASH2L-KDM6B-KDM6B-WDR5 complex
CORUM:6850	1.74075664942e-07	0.12	WDR5 RBBP5 ASH2L	WRA complex (WDR5, RBBP5, ASH2L)
CORUM:2721	4.70464008937e-07	0.16	WDR5 ASH2L HCFC1 SETD1A	HCF-1 complex
GO:0045815	5.76492606644e-07	0.24	MEN1 DPY30 ASH2L WDR5 RBBP5 KMT2A	transcription initiation-coupled chromatin remodeling
CORUM:6845	6.95516388627e-07	0.12	WDR5 RBBP5 ASH2L	NIF1-ASH2L-RBBP5-WDR5 complex
GO:0141137	7.03815856693e-07	0.24	MEN1 DPY30 ASH2L WDR5 RBBP5 KMT2A	positive regulation of gene expression, epigenetic
GO:0071824	7.23801988737e-07	0.48	WDR5 HCFC1 MEN1 HCFC2 PAXIP1 KMT2A DPY30 SETD1A ASH2L KDM6A KMT2D RBBP5	protein-DNA complex organization
GO:0006338	8.20115914183e-07	0.44	WDR5 HCFC1 DPY30 HCFC2 PAXIP1 KMT2A MEN1 RBBP5 ASH2L KDM6A KMT2D	chromatin remodeling
GO:0140938	1.02915357022e-06	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	histone H3 methyltransferase activity
GO:0005654	2.22828821495e-06	0.88	PAXIP1 WDR5 PAGR1 ASH2L NCOA6 UTY MEN1 KMT2B SETD1B KMT2A BOD1L1 BOD1 HCFC2 RBBP5 KDM6A CXXC1 HCFC1 KMT2C DPY30 SETD1A KMT2D ATN1	nucleoplasm
GO:0006352	3.42832146998e-06	0.32	MEN1 WDR5 ASH2L NCOA6 PAXIP1 DPY30 RBBP5 KMT2A	DNA-templated transcription initiation
KEGG:04934	3.47452133862e-06	0.24	MEN1 ASH2L KMT2A WDR5 RBBP5 KMT2D	Cushing syndrome
GO:0042054	5.86645642053e-06	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	histone methyltransferase activity
GO:0016279	6.71745447672e-06	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	protein-lysine N-methyltransferase activity
GO:0016278	7.66851979898e-06	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	lysine N-methyltransferase activity
GO:0031981	8.68652695584e-06	0.88	PAXIP1 WDR5 PAGR1 ASH2L NCOA6 UTY MEN1 KMT2B SETD1B KMT2A BOD1L1 BOD1 HCFC2 RBBP5 KDM6A CXXC1 HCFC1 KMT2C DPY30 SETD1A KMT2D ATN1	nuclear lumen
GO:0140993	9.27382325707e-06	0.32	KMT2A KMT2B KMT2C KMT2D SETD1A KDM6A SETD1B UTY	histone modifying activity
REAC:R-HSA-1266738	1.7279654678e-05	0.44	PAXIP1 WDR5 ASH2L KMT2C NCOA6 KMT2D DPY30 RBBP5 KDM6A PAGR1 KMT2A	Developmental Biology
GO:0006367	3.52990080439e-05	0.28	MEN1 DPY30 ASH2L PAXIP1 WDR5 RBBP5 KMT2A	transcription initiation at RNA polymerase II promoter
HP:0007655	0.000104918110483	0.12	KDM6A KMT2D KMT2A	Eversion of lateral third of lower eyelids
REAC:R-HSA-212436	0.00011098604837	0.44	WDR5 DPY30 KMT2B KMT2C KMT2A MEN1 SETD1A ASH2L SETD1B KMT2D RBBP5	Generic Transcription Pathway
GO:0008170	0.000122090076991	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	N-methyltransferase activity
REAC:R-HSA-3769402	0.000122714344573	0.16	MEN1 ASH2L KMT2D RBBP5	Deactivation of the beta-catenin transactivating complex
GO:0008276	0.000155214918881	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	protein methyltransferase activity
REAC:R-HSA-73857	0.000334254932195	0.44	WDR5 DPY30 KMT2B KMT2C KMT2A MEN1 SETD1A ASH2L SETD1B KMT2D RBBP5	RNA Polymerase II Transcription
GO:0010557	0.000369210970618	0.6	WDR5 HCFC1 CXXC1 MEN1 KMT2A KMT2B KMT2C NCOA6 ZXDC PAXIP1 DPY30 RBBP5 ASH2L PAGR1 KMT2D	positive regulation of macromolecule biosynthetic process
GO:0040029	0.000382953243697	0.28	MEN1 WDR5 ASH2L KMT2D DPY30 RBBP5 KMT2A	epigenetic regulation of gene expression
CORUM:1257	0.000554393175707	0.12	WDR5 KMT2A RBBP5	ALL-1 supercomplex
GO:0031328	0.00055566379204	0.6	WDR5 HCFC1 CXXC1 MEN1 KMT2A KMT2B KMT2C NCOA6 ZXDC PAXIP1 DPY30 RBBP5 ASH2L PAGR1 KMT2D	positive regulation of cellular biosynthetic process
GO:0009891	0.000606884336311	0.6	WDR5 HCFC1 CXXC1 MEN1 KMT2A KMT2B KMT2C NCOA6 ZXDC PAXIP1 DPY30 RBBP5 ASH2L PAGR1 KMT2D	positive regulation of biosynthetic process
GO:0006351	0.000717118355083	0.68	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C ZXDC NCOA6 PAXIP1 DPY30 RBBP5 KMT2B PAGR1 KMT2D ATN1	DNA-templated transcription
WP:WP4949	0.000724973262957	0.16	PAXIP1 PAGR1 KMT2D KMT2C	16p11 2 proximal deletion syndrome
GO:0031974	0.000771803447463	0.88	PAXIP1 WDR5 PAGR1 ASH2L NCOA6 UTY MEN1 KMT2B SETD1B KMT2A BOD1L1 BOD1 HCFC2 RBBP5 KDM6A CXXC1 HCFC1 KMT2C DPY30 SETD1A KMT2D ATN1	membrane-enclosed lumen
GO:0070013	0.000771803447463	0.88	PAXIP1 WDR5 PAGR1 ASH2L NCOA6 UTY MEN1 KMT2B SETD1B KMT2A BOD1L1 BOD1 HCFC2 RBBP5 KDM6A CXXC1 HCFC1 KMT2C DPY30 SETD1A KMT2D ATN1	intracellular organelle lumen
GO:0043233	0.000771803447463	0.88	PAXIP1 WDR5 PAGR1 ASH2L NCOA6 UTY MEN1 KMT2B SETD1B KMT2A BOD1L1 BOD1 HCFC2 RBBP5 KDM6A CXXC1 HCFC1 KMT2C DPY30 SETD1A KMT2D ATN1	organelle lumen
GO:0032774	0.000846816995532	0.68	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C ZXDC NCOA6 PAXIP1 DPY30 RBBP5 KMT2B PAGR1 KMT2D ATN1	RNA biosynthetic process
HP:0011298	0.000849106800314	0.16	KDM6A KMT2D ATN1 KMT2A	Prominent digit pad
GO:0006366	0.00115780852281	0.6	WDR5 HCFC1 MEN1 KMT2A HCFC2 KMT2C ZXDC NCOA6 PAXIP1 DPY30 RBBP5 ASH2L PAGR1 KMT2D ATN1	transcription by RNA polymerase II
GO:0005634	0.00145266710489	0.92	PAXIP1 WDR5 PAGR1 ASH2L ZXDC UTY MEN1 KMT2B SETD1B KMT2A BOD1L1 BOD1 HCFC2 RBBP5 KDM6A CXXC1 HCFC1 KMT2C KMT2D DPY30 SETD1A NCOA6 ATN1	nucleus
GO:0010468	0.00145844579991	0.76	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 ZXDC UTY PAXIP1 DPY30 NCOA6 RBBP5 KMT2B KDM6A KMT2D ATN1	regulation of gene expression
GO:0045893	0.00194346487836	0.48	HCFC1 CXXC1 WDR5 KMT2A KMT2B KMT2C NCOA6 ZXDC PAXIP1 MEN1 PAGR1 KMT2D	positive regulation of DNA-templated transcription
GO:1902680	0.00200617874889	0.48	HCFC1 CXXC1 WDR5 KMT2A KMT2B KMT2C NCOA6 ZXDC PAXIP1 MEN1 PAGR1 KMT2D	positive regulation of RNA biosynthetic process
GO:0010556	0.00249930001227	0.76	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 ZXDC UTY PAXIP1 DPY30 NCOA6 RBBP5 KMT2B KDM6A KMT2D ATN1	regulation of macromolecule biosynthetic process
REAC:R-HSA-201722	0.00268927117463	0.16	MEN1 ASH2L KMT2D RBBP5	Formation of the beta-catenin:TCF transactivating complex
GO:0008757	0.00309908982581	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	S-adenosylmethionine-dependent methyltransferase activity
GO:0031326	0.00365368806431	0.76	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 ZXDC UTY PAXIP1 DPY30 NCOA6 RBBP5 KMT2B KDM6A KMT2D ATN1	regulation of cellular biosynthetic process
CORUM:7221	0.00395240359945	0.08	WDR5 HCFC1	NSL complex
GO:0009889	0.00404578246992	0.76	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 ZXDC UTY PAXIP1 DPY30 NCOA6 RBBP5 KMT2B KDM6A KMT2D ATN1	regulation of biosynthetic process
HP:0000826	0.00421494454294	0.2	MEN1 KDM6A KMT2C KMT2D KMT2B	Precocious puberty
HP:0100000	0.00436377371678	0.2	MEN1 KDM6A KMT2C KMT2D KMT2B	Early onset of sexual maturation
GO:0034654	0.00586753115279	0.68	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C ZXDC NCOA6 PAXIP1 DPY30 RBBP5 KMT2B PAGR1 KMT2D ATN1	nucleobase-containing compound biosynthetic process
GO:0051254	0.0068802507219	0.48	HCFC1 CXXC1 WDR5 KMT2A KMT2B KMT2C NCOA6 ZXDC PAXIP1 MEN1 PAGR1 KMT2D	positive regulation of RNA metabolic process
GO:0008168	0.00735998774456	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	methyltransferase activity
GO:0018130	0.00775171579932	0.68	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C ZXDC NCOA6 PAXIP1 DPY30 RBBP5 KMT2B PAGR1 KMT2D ATN1	heterocycle biosynthetic process
GO:0019438	0.00787833162943	0.68	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C ZXDC NCOA6 PAXIP1 DPY30 RBBP5 KMT2B PAGR1 KMT2D ATN1	aromatic compound biosynthetic process
GO:0060255	0.00908178156982	0.8	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 ZXDC UTY PAXIP1 DPY30 NCOA6 RBBP5 KMT2B KDM6A KMT2D ATN1	regulation of macromolecule metabolic process
GO:0031323	0.00947865288203	0.8	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 ZXDC UTY PAXIP1 DPY30 NCOA6 RBBP5 KMT2B KDM6A KMT2D ATN1	regulation of cellular metabolic process
HP:0002000	0.0104040094697	0.12	KDM6A KMT2D KMT2A	Short columella
GO:0016741	0.0104449787576	0.24	KMT2B KMT2C KMT2D SETD1A SETD1B KMT2A	transferase activity, transferring one-carbon groups
GO:0032991	0.011748493623	0.84	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 NCOA6 KMT2B KMT2D PAXIP1 DPY30 SETD1A RBBP5 KDM6A SETD1B UTY BOD1L1	protein-containing complex
HP:0000437	0.0118093935714	0.12	KDM6A KMT2D KMT2A	Depressed nasal tip
GO:1901362	0.0122400863066	0.68	WDR5 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C ZXDC NCOA6 PAXIP1 DPY30 RBBP5 KMT2B PAGR1 KMT2D ATN1	organic cyclic compound biosynthetic process
GO:0045322	0.0123105223466	0.12	KMT2B KMT2A CXXC1	unmethylated CpG binding
HP:0009929	0.0126714080743	0.16	KDM6A KMT2D ATN1 KMT2A	Abnormal columella morphology
HP:0005218	0.0200236591895	0.08	KDM6A KMT2D	Anoperineal fistula
HP:0010447	0.0200236591895	0.08	KDM6A KMT2D	Anal fistula
KEGG:03083	0.0223156640637	0.12	HCFC2 HCFC1 WDR5	Polycomb repressive complex
GO:0031325	0.0224713170857	0.6	WDR5 HCFC1 CXXC1 MEN1 KMT2A KMT2B KMT2C NCOA6 ZXDC PAXIP1 DPY30 RBBP5 ASH2L PAGR1 KMT2D	positive regulation of cellular metabolic process
GO:0045935	0.0293283367677	0.48	HCFC1 CXXC1 WDR5 KMT2A KMT2B KMT2C NCOA6 ZXDC PAXIP1 MEN1 PAGR1 KMT2D	positive regulation of nucleobase-containing compound metabolic process
HP:0000695	0.0332280832045	0.12	KDM6A KMT2D KMT2C	Natal tooth
GO:0010604	0.0335828690724	0.6	WDR5 HCFC1 CXXC1 MEN1 KMT2A KMT2B KMT2C NCOA6 ZXDC PAXIP1 DPY30 RBBP5 ASH2L PAGR1 KMT2D	positive regulation of macromolecule metabolic process
HP:0004426	0.0398312871762	0.2	SETD1B KMT2B KMT2D KDM6A SETD1A	Abnormal cheek morphology
GO:0019222	0.0420606885469	0.8	WDR5 BOD1 ASH2L HCFC1 CXXC1 MEN1 KMT2A HCFC2 KMT2C PAGR1 ZXDC UTY PAXIP1 DPY30 NCOA6 RBBP5 KMT2B KDM6A KMT2D ATN1	regulation of metabolic process
HP:0001212	0.0498770684744	0.12	KDM6A KMT2D ATN1	Prominent fingertip pads

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
RBBP5	ASH2L	1.0	0.438	structurally_consistent (dimer)
CXXC1	RBBP5	1.0	0.27	structurally_consistent (dimer)
RBBP5	SETD1A	1.0	0.208	mutually_exclusive (P61964)
SETD1B	RBBP5	1.0	0.106
CXXC1	SETD1A	1.0	0.46
KMT2A	HCFC2	1.0	0.144
WDR5	RBBP5	1.0	0.574	structurally_consistent (dimer)
CXXC1	WDR5	1.0	0.464	structurally_consistent (dimer)
CXXC1	ASH2L	1.0	0.474	structurally_consistent (Q15291)
CXXC1	SETD1B	1.0	0.236
HCFC2	ASH2L	0.999	0.276
CXXC1	BOD1L1	0.999	0.256
HCFC2	HCFC1	0.999	0.196
PAGR1	PAXIP1	0.999	0.176
HCFC2	SETD1A	0.999	0.462
SETD1B	ASH2L	0.999	0.22
BOD1L1	SETD1A	0.999	0.392
BOD1L1	HCFC2	0.999	0.188
CXXC1	HCFC2	0.999	0.306
SETD1A	ASH2L	0.999	0.566
CXXC1	BOD1	0.999	0.128
KMT2A	RBBP5	0.999	0.156
BOD1L1	RBBP5	0.999	0.324
WDR5	BOD1L1	0.999	0.198
BOD1	ASH2L	0.999	0.182
CXXC1	HCFC1	0.999	0.274
PAGR1	KMT2D	0.998	0.106
WDR5	ASH2L	0.998	0.236	structurally_consistent (Q15291)
PAGR1	UTY	0.998
RBBP5	KMT2D	0.998	0.11
WDR5	SETD1A	0.998	0.168	structurally_consistent (dimer)
RBBP5	BOD1	0.998	0.134
DPY30	RBBP5	0.998	0.466
BOD1L1	ASH2L	0.998	0.386
KMT2A	ASH2L	0.997	0.196
CXXC1	DPY30	0.997	0.234	structurally_consistent (P61964)
DPY30	ASH2L	0.997	0.414
SETD1B	BOD1	0.996	0.166
HCFC2	RBBP5	0.996	0.348
WDR5	KMT2B	0.996	0.338
WDR5	KMT2A	0.996	0.228
HCFC2	KMT2B	0.995	0.276
ATN1	WDR5	0.994	0.142	structurally_consistent (dimer)
HCFC1	SETD1A	0.994	0.448
BOD1L1	HCFC1	0.993	0.138
WDR5	SETD1B	0.993	0.172
KDM6A	RBBP5	0.993	0.316	mutually_exclusive (P61964)
WDR5	HCFC1	0.992	0.14
HCFC1	ASH2L	0.992	0.168
HCFC1	RBBP5	0.989	0.068
WDR5	HCFC2	0.988	0.192
NCOA6	WDR5	0.984	0.352
KDM6A	KMT2D	0.983	0.192
RBBP5	KMT2B	0.982	0.196
WDR5	KMT2D	0.982	0.0641691542289
WDR5	KDM6A	0.981	0.312	structurally_consistent (dimer)
BOD1L1	KDM6A	0.98	0.15
ASH2L	KMT2D	0.978	0.09203125
ASH2L	KMT2B	0.977	0.21
RBBP5	PAXIP1	0.976	0.31	mutually_exclusive (P61964)
SETD1B	KDM6A	0.976	0.28
KMT2A	KDM6A	0.976	0.284
PAXIP1	KMT2D	0.975	0.172
WDR5	DPY30	0.973	0.3825	structurally_consistent (dimer)
KDM6A	ASH2L	0.973	0.204
RBBP5	KMT2C	0.972	0.094
KMT2A	KMT2D	0.969	0.118
BOD1L1	KMT2D	0.968	0.098
SETD1B	KMT2D	0.966	0.124
ATN1	RBBP5	0.964	0.12	mutually_exclusive (P61964)
WDR5	BOD1	0.962	0.222
CXXC1	KMT2A	0.962	0.196
SETD1B	SETD1A	0.96	0.304
KMT2C	ASH2L	0.955	0.082
BOD1L1	BOD1	0.955	0.132
SETD1A	KMT2D	0.95	0.102
BOD1L1	KMT2A	0.947	0.18
MEN1	ASH2L	0.946	0.228
SETD1B	KMT2A	0.946	0.222
HCFC2	DPY30	0.945	0.34
BOD1L1	SETD1B	0.945	0.196
WDR5	C21orf58	0.944
CXXC1	KDM6A	0.943	0.208
KMT2A	SETD1A	0.941	0.204
BOD1	SETD1A	0.94	0.062
SETD1B	HCFC1	0.94	0.14
PAXIP1	ASH2L	0.937	0.144
WDR5	PAXIP1	0.935	0.392	structurally_consistent (dimer)
KDM6A	SETD1A	0.93	0.228
WDR5	MEN1	0.923	0.214
CXXC1	KMT2D	0.922	0.218
ATN1	SETD1A	0.92	0.15	mutually_exclusive (P61964)
UTY	PAXIP1	0.91
HCFC2	MEN1	0.906	0.128
KMT2C	MEN1	0.903	0.036
CXXC1	ATN1	0.902	0.316
UTY	KMT2D	0.902
WDR5	ZXDC	0.891	0.058
KDM6A	HCFC1	0.853	0.12
ASH2L	AK7	0.844
SETD1B	HCFC2	0.842	0.154
NCOA6	ASH2L	0.835	0.318
KMT2A	HCFC1	0.825	0.09
KDM6A	DPY30	0.824	0.212
ATN1	ASH2L	0.811	0.194
NCOA6	RBBP5	0.805	0.346
SETD1B	KMT2B	0.802	0.27
NCOA6	BOD1	0.798	0.134
KDM6A	BOD1	0.798	0.152
BOD1	KMT2D	0.798	0.134
BOD1	KMT2B	0.795	0.112
NCOA6	SETD1B	0.791	0.192
HCFC2	KDM6A	0.769	0.22
SETD1A	KMT2B	0.768	0.236
NCOA6	KMT2D	0.759	0.118
CXXC1	KMT2B	0.751	0.322
HCFC1	KMT2B	0.737	0.124
RBBP5	MEN1	0.733	0.412
DPY30	KMT2B	0.717	0.242
ATN1	KMT2A	0.712	0.152
HCFC1	BOD1	0.705	0.226
PAGR1	DPY30	0.705	0.174
PAGR1	KDM6A	0.689	0.118
KDM6A	PAXIP1	0.678	0.298
DPY30	BOD1	0.673	0.104
ATN1	HCFC1	0.672	0.126
SETD1B	PAXIP1	0.672	0.148
NCOA6	KDM6A	0.671	0.268
ATN1	MEN1	0.67	0.154
NCOA6	PAXIP1	0.66	0.238
MEN1	KMT2B	0.654	0.224
NCOA6	BOD1L1	0.641	0.242
RBBP5	C21orf58	0.621
DPY30	SETD1A	0.606	0.154
PAXIP1	KMT2B	0.605	0.264
HCFC1	MEN1	0.599	0.118
KMT2B	KMT2D	0.594	0.166
ATN1	HCFC2	0.592	0.218
DPY30	KMT2D	0.589	0.184
NCOA6	KMT2B	0.566	0.12
MEN1	ZXDC	0.556	0.114
BOD1L1	PAXIP1	0.551	0.2
NCOA6	KMT2A	0.533	0.14
HCFC1	PAXIP1	0.533	0.108
KDM6A	KMT2B	0.524	0.258
KMT2A	PAXIP1	0.516	0.124
KMT2A	KMT2B	0.511	0.23
BOD1L1	KMT2B	0.505	0.186
MEN1	KMT2D	0.503	0.038
BOD1L1	DPY30	0.499	0.362
ATN1	ZXDC	0.498	0.132
KMT2C	PAXIP1	0.479	0.144
CXXC1	NCOA6	0.469	0.216
KDM6A	MEN1	0.469	0.108
BOD1	PAXIP1	0.461	0.086
SETD1B	DPY30	0.452	0.212
HCFC2	KMT2D	0.449	0.08
ATN1	KMT2B	0.446	0.168
KMT2A	MEN1	0.437	0.218
ATN1	BOD1L1	0.431	0.186
NCOA6	ATN1	0.417	0.296
KDM6A	AK7	0.415
NCOA6	AK7	0.415
KMT2D	AK7	0.415
SETD1B	AK7	0.415
KMT2C	AK7	0.415
KMT2B	AK7	0.415
ATN1	PAXIP1	0.415	0.252	mutually_exclusive (P61964)
ATN1	SETD1B	0.401	0.318
ATN1	KMT2D	0.4	0.152
NCOA6	SETD1A	0.398	0.206
ASH2L	C21orf58	0.391
ATN1	KDM6A	0.389	0.226
KMT2D	ZXDC	0.382	0.106
HCFC1	KMT2D	0.381	0.088
KMT2B	ZXDC	0.378	0.158
SETD1B	ZXDC	0.378	0.114
KDM6A	ZXDC	0.378	0.1
NCOA6	MEN1	0.377	0.194
KMT2A	BOD1	0.373	0.15
NCOA6	ZXDC	0.364	0.146
KMT2A	DPY30	0.362	0.078
HCFC2	ZXDC	0.361	0.14
ATN1	BOD1	0.357	0.098
NCOA6	HCFC2	0.293	0.212
NCOA6	KMT2C	0.288	0.126
PAXIP1	SETD1A	0.283	0.148
PAXIP1	AK7	0.278
HCFC2	BOD1	0.276	0.236
BOD1	AK7	0.274
NCOA6	HCFC1	0.273	0.184
DPY30	MEN1	0.273	0.258
KDM6A	KMT2C	0.266	0.166
PAXIP1	MEN1	0.262	0.158
DPY30	PAXIP1	0.254	0.234
KMT2A	AK7	0.254
CXXC1	PAXIP1	0.25	0.306
BOD1L1	AK7	0.25
SETD1A	ZXDC	0.245	0.062
CXXC1	ZXDC	0.242	0.132
HCFC2	PAXIP1	0.229	0.082
BOD1	ZXDC	0.224	0.108
PAXIP1	ZXDC	0.224	0.118
BOD1L1	ZXDC	0.215	0.228
KMT2A	ZXDC	0.215	0.106
UTY	KDM6A	0.214
ATN1	KMT2C	0.21	0.128
ASH2L	ZXDC	0.198	0.09
BOD1L1	MEN1	0.194	0.132
HCFC1	DPY30	0.193	0.164
CXXC1	MEN1	0.188	0.344
HCFC1	ZXDC	0.179	0.122
RBBP5	ZXDC	0.163	0.076
SETD1B	MEN1	0.163	0.086
SETD1A	MEN1	0.15	0.114
BOD1	MEN1	0.131	0.138
ATN1	DPY30	0.128	0.222	mutually_exclusive (P61964)
DPY30	ZXDC	0.119	0.186
NCOA6	DPY30	0.117	0.366
RBBP5	AK7	0.101
KMT2C	KMT2D	0.099	0.046
CXXC1	KMT2C	0.095	0.144
KMT2C	SETD1A	0.095	0.144
HCFC1	AK7	0.089
MEN1	AK7	0.085
WDR5	AK7	0.085
HCFC2	AK7	0.085
HCFC2	KMT2C	0.082	0.112
WDR5	KMT2C	0.081	0.042
KMT2C	KMT2B	0.079	0.092
KMT2C	BOD1	0.079	0.096
SETD1B	KMT2C	0.079	0.104
BOD1L1	KMT2C	0.079	0.096
CXXC1	AK7	0.078
SETD1A	AK7	0.078
DPY30	KMT2C	0.078	0.1
DPY30	AK7	0.077
KMT2A	KMT2C	0.071	0.07
UTY	RBBP5	0.063
UTY	DPY30	0.039
HCFC1	KMT2C	0.024	0.19
PAGR1	RBBP5	0.019	0.148
PAGR1	ASH2L	0.017	0.134
DPY30	C21orf58	0.013
WDR5	PAGR1	0.006	0.288
HCFC1	C21orf58	0.001
PAGR1	HCFC1	0.001	0.138

Related Complexes

Genename	Complexes
UTY	huMAP3_00175.1 huMAP3_11602.1 huMAP3_12119.1 huMAP3_12373.1 huMAP3_14057.1 huMAP3_14367.1
SETD1B	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
ZXDC	huMAP3_11602.1
KMT2D	huMAP3_07585.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_12119.1 huMAP3_12373.1 huMAP3_14057.1 huMAP3_14367.1
HCFC2	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
HCFC1	huMAP3_00564.1 huMAP3_02029.1 huMAP3_07065.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09094.1 huMAP3_10106.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_13421.1
DPY30	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_13844.1
SETD1A	huMAP3_02698.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
NCOA6	huMAP3_00047.1 huMAP3_05103.1 huMAP3_07585.1 huMAP3_08776.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
C21orf58	huMAP3_11602.1 huMAP3_13700.1
KDM6A	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KMT2B	huMAP3_05393.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_15009.1
MEN1	huMAP3_04304.1 huMAP3_11602.1 huMAP3_12999.1
AK7	huMAP3_11602.1
BOD1L1	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KMT2A	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
PAGR1	huMAP3_00175.1 huMAP3_11602.1 huMAP3_12119.1 huMAP3_12373.1 huMAP3_14057.1 huMAP3_14367.1
CXXC1	huMAP3_00047.1 huMAP3_02698.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
RBBP5	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KMT2C	huMAP3_00564.1 huMAP3_05226.1 huMAP3_06804.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_12999.1
WDR5	huMAP3_00047.1 huMAP3_05103.1 huMAP3_07585.1 huMAP3_08776.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
PAXIP1	huMAP3_01260.1 huMAP3_11602.1 huMAP3_12119.1 huMAP3_12373.1 huMAP3_14057.1 huMAP3_14367.1
BOD1	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_11792.1 huMAP3_15215.1
ASH2L	huMAP3_05226.1 huMAP3_06804.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
ATN1	huMAP3_00047.1 huMAP3_05103.1 huMAP3_07585.1 huMAP3_08776.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11602.1

Complex Portal: CPX-18950