hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11608.1
Complex Portal: CPX-13503
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SENP7 | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | 5 | UniProt NCBI |
| DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | 5 | UniProt NCBI |
| SETDB2 | Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00310 | 0.00125862804941 | 0.666666666667 | DOT1L SETDB2 | Lysine degradation |
| WP:WP2369 | 0.00213615497188 | 0.666666666667 | DOT1L SETDB2 | Histone modifications |
| REAC:R-HSA-3214841 | 0.015485676782 | 0.666666666667 | DOT1L SETDB2 | PKMTs methylate histone lysines |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SETDB2 | SENP7 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DOT1L | SETDB2 | 0.923 | bioplex3_WMM WMM_only | ||
| DOT1L | SENP7 | 0.905 | 0.084 | bioplex3_WMM WMM_only |
Related Complexes