hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11616.1

Complex Portal: CPX-11334

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
TLE5	TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)	5	UniProt NCBI
HLX	H2.0-like homeobox protein (Homeobox protein HB24) (Homeobox protein HLX1)	5	UniProt NCBI
RIPPLY1	Protein ripply1	5	UniProt NCBI
TLE4	Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)	5	UniProt NCBI
TLE3	Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)	5	UniProt NCBI
EN1	Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1)	5	UniProt NCBI
TIFA	TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein)	5	UniProt NCBI
TLE2	Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)	5	UniProt NCBI
HES1	Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)	5	UniProt NCBI
RIPPLY3	Protein ripply3 (Down syndrome critical region protein 6)	5	UniProt NCBI
RIPPLY2	Protein ripply2	5	UniProt NCBI
HES4	Transcription factor HES-4 (hHES4) (Class B basic helix-loop-helix protein 42) (bHLHb42) (Hairy and enhancer of split 4) (bHLH factor Hes4)	4	UniProt NCBI
TLE1	Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)	5	UniProt NCBI
TBX1	T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T-box protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-4641265	4.66446922608e-11	0.357142857143	TLE1 TLE4 TLE2 TLE5 TLE3	Repression of WNT target genes
KEGG:04330	3.35847163093e-08	0.357142857143	TLE1 TLE4 TLE2 HES1 TLE3	Notch signaling pathway
REAC:R-HSA-195253	2.49533311266e-06	0.357142857143	TLE1 TLE4 TLE2 TLE5 TLE3	Degradation of beta-catenin by the destruction complex
REAC:R-HSA-3769402	8.56475807908e-06	0.285714285714	TLE4 TLE2 TLE1 TLE3	Deactivation of the beta-catenin transactivating complex
REAC:R-HSA-2122947	1.32589491826e-05	0.285714285714	TLE1 TLE4 HES1 TLE2	NOTCH1 Intracellular Domain Regulates Transcription
CORUM:3124	4.44741811353e-05	0.142857142857	TLE2 TLE1	TLE1-TLE2 complex
REAC:R-HSA-1980143	6.53455283847e-05	0.285714285714	TLE1 TLE4 HES1 TLE2	Signaling by NOTCH1
REAC:R-HSA-201722	0.00019238872153	0.285714285714	TLE4 TLE2 TLE1 TLE3	Formation of the beta-catenin:TCF transactivating complex
GO:0009952	0.000226875309753	0.357142857143	HES4 HES1 RIPPLY1 TBX1 RIPPLY2	anterior/posterior pattern specification
GO:0007389	0.000415428760437	0.428571428571	HES4 HES1 TBX1 RIPPLY1 RIPPLY2 RIPPLY3	pattern specification process
KEGG:04310	0.000547862131151	0.285714285714	TLE4 TLE2 TLE1 TLE3	Wnt signaling pathway
GO:0045892	0.000654306420384	0.642857142857	TLE5 HES1 EN1 TLE1 TLE4 RIPPLY1 RIPPLY2 TLE2 RIPPLY3	negative regulation of DNA-templated transcription
GO:1902679	0.000723613830293	0.642857142857	TLE5 HES1 EN1 TLE1 TLE4 RIPPLY1 RIPPLY2 TLE2 RIPPLY3	negative regulation of RNA biosynthetic process
GO:0090090	0.000847703063704	0.357142857143	TLE1 TLE4 TLE2 TLE5 TLE3	negative regulation of canonical Wnt signaling pathway
GO:0140110	0.00146383566563	0.714285714286	TLE3 TLE5 HES1 EN1 TLE1 TLE4 TBX1 TLE2 HLX HES4	transcription regulator activity
REAC:R-HSA-195721	0.00162131816748	0.357142857143	TLE1 TLE4 TLE2 TLE5 TLE3	Signaling by WNT
GO:0051253	0.00170266729825	0.642857142857	TLE5 HES1 EN1 TLE1 TLE4 RIPPLY1 RIPPLY2 TLE2 RIPPLY3	negative regulation of RNA metabolic process
GO:0030178	0.00261438965601	0.357142857143	TLE1 TLE4 TLE2 TLE5 TLE3	negative regulation of Wnt signaling pathway
WP:WP2854	0.00356167266499	0.142857142857	HES1 RIPPLY2	Gene regulatory network modelling somitogenesis
GO:0045934	0.00408235369842	0.642857142857	TLE5 HES1 EN1 TLE1 TLE4 RIPPLY1 RIPPLY2 TLE2 RIPPLY3	negative regulation of nucleobase-containing compound metabolic process
GO:1990907	0.00765826511887	0.214285714286	TLE4 TLE1 TLE3	beta-catenin-TCF complex
REAC:R-HSA-157118	0.00928770822144	0.285714285714	TLE1 TLE4 HES1 TLE2	Signaling by NOTCH
REAC:R-HSA-201681	0.00983417862561	0.285714285714	TLE4 TLE2 TLE1 TLE3	TCF dependent signaling in response to WNT
GO:0003002	0.0132339484338	0.357142857143	HES4 HES1 RIPPLY1 TBX1 RIPPLY2	regionalization
GO:0003714	0.0132339484338	0.357142857143	TLE1 TLE4 TLE2 TLE5 TLE3	transcription corepressor activity
GO:0060828	0.0164000800469	0.357142857143	TLE1 TLE4 TLE2 TLE5 TLE3	regulation of canonical Wnt signaling pathway
GO:0006355	0.0171988947556	0.785714285714	HES4 TLE5 HES1 EN1 TLE1 TLE4 RIPPLY1 TBX1 RIPPLY2 TLE2 RIPPLY3	regulation of DNA-templated transcription
GO:2001141	0.0183270923787	0.785714285714	HES4 TLE5 HES1 EN1 TLE1 TLE4 RIPPLY1 TBX1 RIPPLY2 TLE2 RIPPLY3	regulation of RNA biosynthetic process
GO:0006351	0.0282778170099	0.785714285714	HES4 TLE5 HES1 EN1 TLE1 TLE4 RIPPLY1 TBX1 RIPPLY2 TLE2 RIPPLY3	DNA-templated transcription
GO:0000122	0.030267479466	0.5	TLE5 HES1 EN1 TLE4 RIPPLY3 RIPPLY2 RIPPLY1	negative regulation of transcription by RNA polymerase II
GO:0032774	0.0316271774281	0.785714285714	HES4 TLE5 HES1 EN1 TLE1 TLE4 RIPPLY1 TBX1 RIPPLY2 TLE2 RIPPLY3	RNA biosynthetic process
WP:WP4844	0.042544943205	0.142857142857	HES1 TLE1	Influence of laminopathies on Wnt signaling
GO:0060070	0.0490014689508	0.357142857143	TLE1 TLE4 TLE2 TLE5 TLE3	canonical Wnt signaling pathway
CORUM:3120	0.0499958217778	0.0714285714286	TLE1	OCT1-OBF1-DNA-TLE1 complex
CORUM:3123	0.0499958217778	0.0714285714286	TLE2	TLE2 homodimer complex
CORUM:3125	0.0499958217778	0.0714285714286	TLE1	TLE1 homodimer complex
CORUM:3127	0.0499958217778	0.0714285714286	TLE1	TLE-Histone H3 complex
CORUM:3164	0.0499958217778	0.0714285714286	TLE1	HESX1-TLE1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
TLE5	TLE4	1.0	0.208	structurally_consistent (dimer)
TLE4	TLE2	1.0		mutually_exclusive (Q08117)
TLE4	TLE1	1.0	0.262
TLE3	TLE2	1.0		mutually_exclusive (Q08117)
TLE5	TLE1	1.0	0.126	structurally_consistent (dimer)
TLE4	TLE3	1.0	0.088	mutually_exclusive (Q08117)
TLE3	TLE1	0.999	0.116	mutually_exclusive (Q08117)
TLE2	TLE1	0.999
TLE5	TLE2	0.999		structurally_consistent (dimer)
RIPPLY2	TLE1	0.999
TLE4	RIPPLY3	0.998
TLE3	RIPPLY2	0.997
TLE2	RIPPLY2	0.997
TLE5	RIPPLY2	0.997
TLE1	HES1	0.997	0.108
RIPPLY1	TLE3	0.996
TLE5	TLE3	0.996	0.182	structurally_consistent (dimer)
RIPPLY3	TLE1	0.99
RIPPLY1	TLE1	0.988
TLE3	RIPPLY3	0.982
TLE2	RIPPLY3	0.977
RIPPLY1	TLE2	0.974
TLE5	RIPPLY3	0.972
TLE3	HLX	0.972
RIPPLY1	TLE4	0.97
TLE4	RIPPLY2	0.97
TLE3	EN1	0.962
RIPPLY3	TIFA	0.954
TLE1	EN1	0.953
RIPPLY3	TBX1	0.94
TLE1	HLX	0.929
TLE5	EN1	0.919
TLE2	EN1	0.901
TLE1	HES4	0.891
TLE5	RIPPLY1	0.884
TLE4	HLX	0.874
TLE1	TBX1	0.873
TLE4	EN1	0.864
TLE2	HLX	0.718
TLE3	HES1	0.536	0.106
TLE3	HES4	0.535
TLE5	HES1	0.435	0.12
TLE2	HES1	0.435
TIFA	TBX1	0.415
HES1	HES4	0.415
HES4	TBX1	0.415
HES1	TBX1	0.415
RIPPLY3	HES4	0.415
TLE5	HLX	0.342
RIPPLY3	HES1	0.274
TLE5	HES4	0.21
TLE4	HES4	0.113
TLE2	HES4	0.113
TLE3	TBX1	0.079
TLE4	TBX1	0.079
TLE5	TBX1	0.079
TLE2	TBX1	0.079
TLE1	TIFA	0.078	0.116
TLE4	HES1	0.078	0.07
TLE4	TIFA	0.078	0.084
TLE3	TIFA	0.078	0.064
TLE5	TIFA	0.078	0.072
TLE2	TIFA	0.078

Related Complexes

Genename	Complexes
TLE5	huMAP3_00022.1 huMAP3_11616.1 huMAP3_14261.1
HLX	huMAP3_01323.1 huMAP3_05934.1 huMAP3_11616.1 huMAP3_14261.1
RIPPLY1	huMAP3_00022.1 huMAP3_11616.1 huMAP3_14261.1 huMAP3_14442.1
TLE4	huMAP3_00022.1 huMAP3_11616.1 huMAP3_14261.1
TLE3	huMAP3_00022.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10799.1 huMAP3_11616.1 huMAP3_14138.1 huMAP3_14261.1
EN1	huMAP3_00022.1 huMAP3_02235.1 huMAP3_10896.1 huMAP3_11616.1 huMAP3_11758.1 huMAP3_14261.1
TIFA	huMAP3_03496.1 huMAP3_04156.1 huMAP3_04466.1 huMAP3_08123.1 huMAP3_11459.1 huMAP3_11616.1 huMAP3_12202.1 huMAP3_14261.1 huMAP3_15091.1
TLE2	huMAP3_00022.1 huMAP3_11616.1 huMAP3_14261.1
HES1	huMAP3_04735.1 huMAP3_05343.1 huMAP3_10896.1 huMAP3_11301.1 huMAP3_11616.1 huMAP3_11989.1 huMAP3_12256.1 huMAP3_12703.1 huMAP3_13437.1 huMAP3_14261.1 huMAP3_14748.1 huMAP3_15181.1
RIPPLY3	huMAP3_00022.1 huMAP3_04466.1 huMAP3_11616.1 huMAP3_14261.1
RIPPLY2	huMAP3_00022.1 huMAP3_11616.1 huMAP3_14261.1
HES4	huMAP3_11616.1 huMAP3_11989.1 huMAP3_12256.1 huMAP3_14261.1
TLE1	huMAP3_00022.1 huMAP3_04735.1 huMAP3_10896.1 huMAP3_11616.1 huMAP3_11989.1 huMAP3_12256.1 huMAP3_14261.1
TBX1	huMAP3_11616.1 huMAP3_11989.1 huMAP3_12256.1 huMAP3_14261.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11616.1

Complex Portal: CPX-11334