hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11621.1

Complex Portal: CPX-14268

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
MYF6	Myogenic factor 6 (Myf-6) (Class C basic helix-loop-helix protein 4) (bHLHc4) (Muscle-specific regulatory factor 4)	5	UniProt NCBI
MESP2	Mesoderm posterior protein 2 (Class C basic helix-loop-helix protein 6) (bHLHc6)	5	UniProt NCBI
ID2	DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)	5	UniProt NCBI
ASCL1	Achaete-scute homolog 1 (ASH-1) (hASH1) (Class A basic helix-loop-helix protein 46) (bHLHa46)	5	UniProt NCBI
NEUROG1	Neurogenin-1 (NGN-1) (Class A basic helix-loop-helix protein 6) (bHLHa6) (Neurogenic basic-helix-loop-helix protein) (Neurogenic differentiation factor 3) (NeuroD3)	5	UniProt NCBI
ASCL4	Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44)	5	UniProt NCBI
NHLH2	Helix-loop-helix protein 2 (HEN-2) (Class A basic helix-loop-helix protein 34) (bHLHa34) (Nescient helix loop helix 2) (NSCL-2)	5	UniProt NCBI
MACF1	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)	5	UniProt NCBI
TCF12	Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)	5	UniProt NCBI
TCF24	Transcription factor 24 (TCF-24)	3	UniProt NCBI
TWIST2	Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1)	5	UniProt NCBI
TCF4	Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)	5	UniProt NCBI
MSGN1	Mesogenin-1 (Paraxial mesoderm-specific mesogenin1) (pMesogenin1) (pMsgn1)	5	UniProt NCBI
ASCL3	Achaete-scute homolog 3 (ASH-3) (hASH3) (Class A basic helix-loop-helix protein 42) (bHLHa42) (bHLH transcriptional regulator Sgn-1)	5	UniProt NCBI
TWIST1	Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist)	5	UniProt NCBI
NEUROD1	Neurogenic differentiation factor 1 (NeuroD) (NeuroD1) (Class A basic helix-loop-helix protein 3) (bHLHa3)	5	UniProt NCBI
MYOG	Myogenin (Class C basic helix-loop-helix protein 3) (bHLHc3) (Myogenic factor 4) (Myf-4)	5	UniProt NCBI
ID1	DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1)	5	UniProt NCBI
ID3	DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)	5	UniProt NCBI
FERD3L	Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist)	5	UniProt NCBI
NEUROD4	Neurogenic differentiation factor 4 (NeuroD4) (Class A basic helix-loop-helix protein 4) (bHLHa4) (Protein atonal homolog 3) (ATH-3) (Atoh3)	5	UniProt NCBI
ID4	DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4)	5	UniProt NCBI
TCF3	Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0006357	1.7777226826e-12	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of transcription by RNA polymerase II
GO:0006366	4.88020858144e-12	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	transcription by RNA polymerase II
GO:0000981	2.33128519903e-10	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000977	3.54076318809e-10	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0006355	4.78817850995e-10	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of DNA-templated transcription
GO:2001141	5.36733175964e-10	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of RNA biosynthetic process
GO:0003700	5.84886059492e-10	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	DNA-binding transcription factor activity
REAC:R-HSA-9031628	7.89677239923e-10	0.3	TCF12 ID1 ID3 ID2 ASCL1 ID4	NGF-stimulated transcription
GO:0006351	1.17114083573e-09	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	DNA-templated transcription
GO:0000976	1.24963347836e-09	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	transcription cis-regulatory region binding
GO:0001067	1.26862398649e-09	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	transcription regulatory region nucleic acid binding
GO:0032774	1.43275720625e-09	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	RNA biosynthetic process
GO:1990837	2.49699200532e-09	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	sequence-specific double-stranded DNA binding
GO:0051252	3.9459941837e-09	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of RNA metabolic process
GO:0043565	7.15605986686e-09	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	sequence-specific DNA binding
GO:0003690	7.44814856096e-09	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	double-stranded DNA binding
GO:0034654	1.5248401352e-08	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	nucleobase-containing compound biosynthetic process
GO:0018130	2.14893545627e-08	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	heterocycle biosynthetic process
GO:0019438	2.19231321565e-08	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	aromatic compound biosynthetic process
GO:0019219	2.20695560435e-08	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of nucleobase-containing compound metabolic process
REAC:R-HSA-198725	2.21025557765e-08	0.3	TCF12 ID1 ID3 ID2 ASCL1 ID4	Nuclear Events (kinase and transcription factor activation)
GO:1901362	3.77905580602e-08	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	organic cyclic compound biosynthetic process
GO:0000785	4.02518183045e-08	0.7	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 ASCL4 FERD3L ID2	chromatin
GO:0032993	9.01472964065e-08	0.7	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 ASCL4 FERD3L ID2	protein-DNA complex
GO:0140110	1.28667378559e-07	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	transcription regulator activity
GO:0016070	2.73224107042e-07	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	RNA metabolic process
GO:0070888	3.85414103667e-07	0.3	NEUROD4 ASCL1 TWIST1 NEUROG1 NEUROD1 MYF6	E-box binding
GO:0010468	5.59944783477e-07	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of gene expression
GO:0044271	6.43509969412e-07	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	cellular nitrogen compound biosynthetic process
GO:0003677	6.57934619033e-07	0.75	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	DNA binding
REAC:R-HSA-187037	8.16220146707e-07	0.3	TCF12 ID1 ID3 ID2 ASCL1 ID4	Signaling by NTRK1 (TRKA)
GO:0010556	1.00276301449e-06	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of macromolecule biosynthetic process
GO:0031326	1.51393588726e-06	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of cellular biosynthetic process
GO:0032502	1.59606349211e-06	0.95	TCF12 NEUROD4 MESP2 MACF1 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	developmental process
GO:0009889	1.69126214568e-06	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of biosynthetic process
REAC:R-HSA-166520	2.1721656391e-06	0.3	TCF12 ID1 ID3 ID2 ASCL1 ID4	Signaling by NTRKs
GO:0090304	2.7263766316e-06	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	nucleic acid metabolic process
GO:0005694	5.57561412541e-06	0.7	TCF12 NEUROD4 MESP2 ASCL1 NHLH2 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 ASCL4 FERD3L ID2	chromosome
GO:0051171	7.17612058426e-06	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of nitrogen compound metabolic process
GO:0080090	1.1373873282e-05	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of primary metabolic process
GO:0006139	1.95449163599e-05	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	nucleobase-containing compound metabolic process
KEGG:04550	2.88703694952e-05	0.25	ID4 ID1 ID2 ID3 NEUROG1	Signaling pathways regulating pluripotency of stem cells
GO:0046483	3.36597768531e-05	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	heterocycle metabolic process
GO:0006725	3.56670104092e-05	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	cellular aromatic compound metabolic process
GO:0060255	4.27642256645e-05	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of macromolecule metabolic process
GO:0031323	4.46873228205e-05	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of cellular metabolic process
WP:WP53	5.90574163022e-05	0.15	ID2 ID3 ID1	ID signaling pathway
GO:1901360	6.9871001575e-05	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	organic cyclic compound metabolic process
GO:0010467	7.51412997758e-05	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	gene expression
GO:0034641	0.000158174015425	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	cellular nitrogen compound metabolic process
GO:0019222	0.000208537920475	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	regulation of metabolic process
GO:0003676	0.00028110733103	0.8	TCF12 NEUROD4 MESP2 MACF1 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	nucleic acid binding
KEGG:04350	0.000315978605449	0.2	ID4 ID2 ID3 ID1	TGF-beta signaling pathway
WP:WP2064	0.00034062333876	0.2	ASCL1 ID1 NEUROG1 TWIST1	Neural crest differentiation
GO:0009059	0.000345596102992	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	macromolecule biosynthetic process
GO:0140416	0.000385345183326	0.2	ID4 ID2 ID3 ID1	transcription regulator inhibitor activity
GO:0000978	0.000823648496632	0.5	TCF12 NEUROD4 MESP2 NHLH2 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL1 MYF6	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000987	0.00100406029715	0.5	TCF12 NEUROD4 MESP2 NHLH2 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL1 MYF6	cis-regulatory region sequence-specific DNA binding
WP:WP3596	0.00219109072329	0.1	ID2 ID1	miR 517 relationship with ARCN1 and USP1
WP:WP4239	0.003399282635	0.2	TWIST1 ID1 ID2 TWIST2	Epithelial to mesenchymal transition in colorectal cancer
GO:0044249	0.0037840951187	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	cellular biosynthetic process
GO:1901576	0.0043975024314	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	organic substance biosynthetic process
GO:0009058	0.00491787214971	0.95	TCF12 NEUROD4 MESP2 ASCL1 ID1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 ID4 FERD3L ID3 ID2	biosynthetic process
REAC:R-HSA-9006934	0.0054516819791	0.3	TCF12 ID1 ID3 ID2 ASCL1 ID4	Signaling by Receptor Tyrosine Kinases
GO:0045597	0.00615414456353	0.4	NEUROD4 MACF1 TWIST1 NEUROD1 NEUROG1 ASCL1 MYF6 ID2	positive regulation of cell differentiation
HP:0011317	0.00634893468462	0.1	TCF12 TWIST1	Right unicoronal synostosis
GO:0097159	0.00690426809364	0.8	TCF12 NEUROD4 MESP2 MACF1 ASCL1 NHLH2 TCF24 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 ASCL4 MYF6 FERD3L TWIST2	organic cyclic compound binding
GO:0090575	0.0116451324349	0.3	TCF12 ASCL1 ASCL3 ASCL4 NEUROD1 MYF6	RNA polymerase II transcription regulator complex
GO:0045944	0.013419954366	0.45	TCF12 NEUROD4 NHLH2 TWIST1 NEUROD1 NEUROG1 ASCL1 MYF6 ASCL3	positive regulation of transcription by RNA polymerase II
GO:0005667	0.0149766825739	0.35	TCF12 ASCL1 NHLH2 NEUROD1 ASCL3 ASCL4 MYF6	transcription regulator complex
GO:0045893	0.016829451828	0.5	TCF12 NEUROD4 NHLH2 TWIST1 NEUROD1 NEUROG1 ASCL3 ASCL1 MYF6 ID2	positive regulation of DNA-templated transcription
GO:1902680	0.0172838173277	0.5	TCF12 NEUROD4 NHLH2 TWIST1 NEUROD1 NEUROG1 ASCL3 ASCL1 MYF6 ID2	positive regulation of RNA biosynthetic process
GO:0043228	0.0242072992367	0.8	TCF12 NEUROD4 MESP2 MACF1 ASCL1 NHLH2 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 FERD3L ID2	non-membrane-bounded organelle
GO:0043232	0.0242072992367	0.8	TCF12 NEUROD4 MESP2 MACF1 ASCL1 NHLH2 TWIST1 MSGN1 NEUROD1 NEUROG1 ASCL3 MYF6 TWIST2 ASCL4 FERD3L ID2	intracellular non-membrane-bounded organelle
WP:WP5074	0.029506639233	0.1	ASCL1 NEUROG1	Kallmann syndrome
GO:0048598	0.0356814839445	0.3	MESP2 TWIST1 NEUROG1 NEUROD1 MSGN1 ID2	embryonic morphogenesis
HP:0011315	0.0442967587625	0.1	TCF12 TWIST1	Unicoronal synostosis
GO:0051254	0.0486253924609	0.5	TCF12 NEUROD4 NHLH2 TWIST1 NEUROD1 NEUROG1 ASCL3 ASCL1 MYF6 ID2	positive regulation of RNA metabolic process
WP:WP2855	0.0499126318911	0.1	ASCL1 NEUROD1	Dopaminergic neurogenesis
CORUM:2937	0.0499436884912	0.05	TCF12	PTF1-bHLH complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
ID4	TCF4	0.997		structurally_consistent (dimer)
ID1	ASCL4	0.997
NHLH2	ID1	0.997		structurally_consistent (dimer)
FERD3L	TCF3	0.996
ASCL4	ID2	0.996		structurally_consistent (dimer)
FERD3L	TCF12	0.996		structurally_consistent (dimer)
MYF6	TCF12	0.995
TCF12	TCF3	0.995
TCF4	ID1	0.994	0.136	structurally_consistent (dimer)
NHLH2	TCF12	0.994
TCF4	TWIST2	0.994		structurally_consistent (dimer)
TCF4	TWIST1	0.992		structurally_consistent (dimer)
TCF4	ID2	0.989		structurally_consistent (dimer)
NHLH2	TCF3	0.989
TCF12	NEUROG1	0.988
ID4	ID2	0.988		mutually_exclusive (A6NI15) structurally_consistent (dimer)
ID1	TCF12	0.988
TCF4	ID3	0.987	0.078	structurally_consistent (dimer)
ASCL4	TCF3	0.986
ID2	TCF3	0.985
TCF12	ASCL4	0.984		structurally_consistent (dimer)
TCF12	TWIST2	0.981		structurally_consistent (dimer)
TCF4	TCF12	0.981
TCF4	FERD3L	0.98		structurally_consistent (dimer)
ASCL3	ID4	0.98
TCF4	MYF6	0.974		structurally_consistent (dimer)
NEUROD1	TCF3	0.973
TCF4	TCF24	0.972		structurally_consistent (dimer)
MYF6	TCF3	0.969
TWIST2	TCF3	0.964		structurally_consistent (dimer)
TCF4	NEUROD1	0.957	0.102	structurally_consistent (dimer)
TCF12	ID2	0.953		mutually_exclusive (Q6XD76)
TCF12	NEUROD1	0.945
TCF4	TCF3	0.942		structurally_consistent (dimer)
TCF3	MSGN1	0.938
ID4	MSGN1	0.933		mutually_exclusive (Q02363) structurally_consistent (dimer)
ASCL3	TCF3	0.929
ID4	MYF6	0.927
TWIST1	TCF12	0.911		mutually_exclusive (Q8WVJ9)
ID1	TCF3	0.907
TCF3	ASCL1	0.901
TCF4	NHLH2	0.899		mutually_exclusive (P41134) structurally_consistent (dimer)
ASCL3	TCF12	0.894		structurally_consistent (dimer)
ID4	MYOG	0.875
MYF6	MACF1	0.868
TCF12	ASCL1	0.867
TCF4	MESP2	0.865
TCF12	MSGN1	0.863
TCF3	NEUROG1	0.851
FERD3L	MACF1	0.848
ID1	ID2	0.831
NEUROD4	TCF12	0.815
ASCL3	TCF4	0.81		structurally_consistent (dimer)
TWIST1	TCF3	0.776		mutually_exclusive (Q8WVJ9)
TCF4	MYOG	0.744		structurally_consistent (dimer)
ID4	TCF12	0.744
TCF4	MACF1	0.741	0.068
TCF12	MESP2	0.711
TCF12	MYOG	0.669
ID4	TCF3	0.661
MACF1	ID2	0.572
TWIST1	ID3	0.572
ID3	ID2	0.572
ID3	TWIST2	0.557
ID3	TCF24	0.557		mutually_exclusive (P15884)
TCF24	TWIST2	0.557		mutually_exclusive (P15884)
TCF4	ASCL1	0.543		structurally_consistent (dimer)
TCF24	ID2	0.53		mutually_exclusive (P15884)
TWIST2	ID2	0.53
TCF4	MSGN1	0.521		structurally_consistent (dimer)
ID3	ID1	0.516	0.076
TWIST1	ID2	0.502
TWIST1	TWIST2	0.502		structurally_consistent (dimer)
TWIST1	TCF24	0.502		mutually_exclusive (P15884)
MACF1	TCF3	0.489
TCF3	MYOG	0.466
TCF4	NEUROG1	0.458		structurally_consistent (dimer)
TCF3	MESP2	0.44
TCF24	ID1	0.363
ID1	TWIST2	0.363
TWIST1	ID1	0.359
ID4	ID3	0.35
TCF12	MACF1	0.272
NEUROD4	TCF3	0.206
ID4	TWIST2	0.172
ID4	TCF24	0.172		mutually_exclusive (P15884)
ID3	TCF12	0.172
TCF24	TCF12	0.164
ID4	ID1	0.164
ID4	MACF1	0.163
ID4	TWIST1	0.15
ID3	MACF1	0.127	0.114
TCF24	MACF1	0.127
ID3	TCF3	0.11
TCF24	TCF3	0.11		mutually_exclusive (P15884)
TWIST2	MACF1	0.108
ID1	MACF1	0.094	0.127
TWIST1	MACF1	0.089
MACF1	MYOG	0.028
NHLH2	MACF1	0.008
MACF1	NEUROG1	0.006
MACF1	MESP2	0.006
ASCL4	MACF1	0.006

Related Complexes

Genename	Complexes
MYF6	huMAP3_01169.1 huMAP3_06158.1 huMAP3_08188.1 huMAP3_10571.1 huMAP3_11621.1
MESP2	huMAP3_11621.1
ID2	huMAP3_06158.1 huMAP3_08188.1 huMAP3_10571.1 huMAP3_11621.1
ASCL1	huMAP3_11621.1 huMAP3_14029.1
NEUROG1	huMAP3_09381.1 huMAP3_11621.1 huMAP3_13304.1 huMAP3_13846.1 huMAP3_14498.1
ASCL4	huMAP3_01169.1 huMAP3_06158.1 huMAP3_08188.1 huMAP3_10571.1 huMAP3_11621.1
NHLH2	huMAP3_01169.1 huMAP3_06158.1 huMAP3_08188.1 huMAP3_08729.1 huMAP3_10571.1 huMAP3_11621.1 huMAP3_12406.1 huMAP3_13593.1
MACF1	huMAP3_01957.1 huMAP3_05639.1 huMAP3_09563.1 huMAP3_11621.1 huMAP3_11637.1 huMAP3_11698.1
TCF12	huMAP3_01169.1 huMAP3_06158.1 huMAP3_08188.1 huMAP3_10571.1 huMAP3_11621.1
TCF24	huMAP3_01044.1 huMAP3_02687.1 huMAP3_08707.1 huMAP3_11621.1
TWIST2	huMAP3_01169.1 huMAP3_03205.1 huMAP3_04696.1 huMAP3_06158.1 huMAP3_08188.1 huMAP3_08712.1 huMAP3_09786.1 huMAP3_10093.1 huMAP3_10571.1 huMAP3_11621.1 huMAP3_12651.1 huMAP3_14814.1 huMAP3_14815.1
TCF4	huMAP3_01011.1 huMAP3_06584.1 huMAP3_08707.1 huMAP3_10571.1 huMAP3_11621.1
MSGN1	huMAP3_11621.1
ASCL3	huMAP3_00499.1 huMAP3_04964.1 huMAP3_11621.1
TWIST1	huMAP3_01011.1 huMAP3_02830.1 huMAP3_05949.1 huMAP3_06435.1 huMAP3_08707.1 huMAP3_10571.1 huMAP3_11442.1 huMAP3_11621.1 huMAP3_12122.1 huMAP3_14860.1
NEUROD1	huMAP3_06584.1 huMAP3_08707.1 huMAP3_10571.1 huMAP3_11621.1
MYOG	huMAP3_11621.1
ID1	huMAP3_01169.1 huMAP3_06158.1 huMAP3_08188.1 huMAP3_10571.1 huMAP3_11621.1
ID3	huMAP3_01011.1 huMAP3_06584.1 huMAP3_08707.1 huMAP3_10571.1 huMAP3_11621.1
FERD3L	huMAP3_01169.1 huMAP3_06158.1 huMAP3_08122.1 huMAP3_08188.1 huMAP3_09284.1 huMAP3_10571.1 huMAP3_11621.1 huMAP3_12946.1
NEUROD4	huMAP3_00989.1 huMAP3_03897.1 huMAP3_11621.1 huMAP3_15247.1
ID4	huMAP3_00499.1 huMAP3_04964.1 huMAP3_11621.1
TCF3	huMAP3_08188.1 huMAP3_10571.1 huMAP3_11621.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11621.1

Complex Portal: CPX-14268