hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11623.1
Complex Portal: CPX-11965
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LZTS1 | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | 5 | UniProt NCBI |
| PDE9A | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) | 5 | UniProt NCBI |
| PALD1 | Paladin | 4 | UniProt NCBI |
| PDE8A | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) | 5 | UniProt NCBI |
| UNC119 | Protein unc-119 homolog A (Retinal protein 4) (hRG4) | 5 | UniProt NCBI |
| PDE8B | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein) | 5 | UniProt NCBI |
| AVPI1 | Arginine vasopressin-induced protein 1 (AVP-induced protein 1) | 5 | UniProt NCBI |
| UNC119B | Protein unc-119 homolog B | 5 | UniProt NCBI |
| DENND4C | DENN domain-containing protein 4C | 5 | UniProt NCBI |
| PRDM16 | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | 5 | UniProt NCBI |
| NPHP3 | Nephrocystin-3 | 5 | UniProt NCBI |
| SLA2 | Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2) | 5 | UniProt NCBI |
| SPDEF | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | 5 | UniProt NCBI |
| ATG2A | Autophagy-related protein 2 homolog A | 5 | UniProt NCBI |
| MACIR | Macrophage immunometabolism regulator | 5 | UniProt NCBI |
| PSKH2 | Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2) | 5 | UniProt NCBI |
| RFTN1 | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5624138 | 0.00409965603802 | 0.117647058824 | UNC119B NPHP3 | Trafficking of myristoylated proteins to the cilium |
| GO:0004114 | 0.04400083428 | 0.176470588235 | PDE9A PDE8B PDE8A | 3',5'-cyclic-nucleotide phosphodiesterase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| UNC119 | NPHP3 | 1.0 | 0.112 |
structurally_consistent (dimer)
|
| UNC119 | UNC119B | 1.0 | 0.32 |
structurally_consistent (dimer)
|
| UNC119B | NPHP3 | 1.0 | 0.07 | |
| UNC119 | MACIR | 0.999 | 0.092 |
structurally_consistent (dimer)
|
| PALD1 | UNC119 | 0.999 | 0.066 | |
| UNC119 | AVPI1 | 0.999 | ||
| PDE9A | UNC119 | 0.999 |
structurally_consistent (dimer)
|
|
| PDE8A | UNC119 | 0.998 | 0.112 | |
| UNC119 | LZTS1 | 0.998 | 0.036 | |
| UNC119 | PSKH2 | 0.998 |
structurally_consistent (dimer)
|
|
| PALD1 | UNC119B | 0.997 | 0.014 | |
| PSKH2 | UNC119B | 0.997 |
structurally_consistent (Q13432)
structurally_consistent (dimer) |
|
| UNC119 | SPDEF | 0.996 | ||
| AVPI1 | MACIR | 0.995 | ||
| AVPI1 | UNC119B | 0.995 | ||
| SPDEF | MACIR | 0.995 | ||
| SPDEF | PRDM16 | 0.994 | ||
| UNC119B | MACIR | 0.994 | 0.056 | |
| ATG2A | RFTN1 | 0.988 | 0.038 | |
| UNC119 | RFTN1 | 0.983 | 0.036 | |
| PDE8B | PDE8A | 0.979 | 0.13 | |
| MACIR | DENND4C | 0.978 | 0.064 | |
| SPDEF | UNC119B | 0.976 | ||
| PALD1 | MACIR | 0.972 | 0.05 | |
| UNC119B | LZTS1 | 0.955 | 0.04 | |
| UNC119B | RFTN1 | 0.948 | 0.014 | |
| PDE8A | PDE9A | 0.947 | ||
| PDE9A | PALD1 | 0.918 | ||
| PDE9A | LZTS1 | 0.916 | ||
| PDE8A | LZTS1 | 0.912 | 0.16 | |
| PDE9A | RFTN1 | 0.896 | ||
| PDE9A | NPHP3 | 0.889 | ||
| PDE8A | RFTN1 | 0.869 | 0.054 | |
| LZTS1 | RFTN1 | 0.868 | 0.046 | |
| MACIR | SLA2 | 0.831 | ||
| PDE8A | NPHP3 | 0.805 | 0.124 | |
| PDE9A | MACIR | 0.789 |
structurally_consistent (Q13432)
|
|
| PALD1 | NPHP3 | 0.74 | 0.082 | |
| RFTN1 | NPHP3 | 0.732 | 0.022 | |
| PALD1 | RFTN1 | 0.73 | 0.042 | |
| PDE8A | PALD1 | 0.668 | 0.046 | |
| PDE8A | MACIR | 0.659 | 0.052 | |
| MACIR | NPHP3 | 0.65 | 0.128 |
mutually_exclusive (Q13432)
|
| RFTN1 | MACIR | 0.614 | 0.128 | |
| PDE9A | UNC119B | 0.605 | ||
| PALD1 | LZTS1 | 0.582 | 0.072 | |
| LZTS1 | NPHP3 | 0.572 | 0.12 | |
| PDE8A | AVPI1 | 0.572 | ||
| PDE9A | AVPI1 | 0.557 | ||
| PDE8A | UNC119B | 0.539 | 0.054 | |
| UNC119B | SLA2 | 0.536 | ||
| AVPI1 | LZTS1 | 0.53 | ||
| LZTS1 | MACIR | 0.448 | 0.09 | |
| PDE8B | UNC119 | 0.379 | 0.092 | |
| AVPI1 | RFTN1 | 0.35 | ||
| PALD1 | AVPI1 | 0.336 | ||
| PDE8B | UNC119B | 0.316 | 0.084 | |
| UNC119 | PRDM16 | 0.268 | ||
| UNC119 | ATG2A | 0.265 | 0.116 | |
| UNC119 | SLA2 | 0.25 | ||
| UNC119B | ATG2A | 0.237 | 0.068 | |
| PRDM16 | MACIR | 0.215 | ||
| UNC119B | PRDM16 | 0.189 | ||
| AVPI1 | NPHP3 | 0.172 | ||
| PALD1 | DENND4C | 0.017 | 0.038 | |
| UNC119B | DENND4C | 0.014 | 0.056 | |
| LZTS1 | DENND4C | 0.014 | 0.074 | |
| PDE8A | DENND4C | 0.014 | 0.084 | |
| PALD1 | PRDM16 | 0.008 |
Related Complexes