hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11629.1
Complex Portal: CPX-23754
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1) | 5 | UniProt NCBI |
| UBQLNL | Ubiquilin-like protein | 4 | UniProt NCBI |
| PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) | 5 | UniProt NCBI |
| IRS2 | Insulin receptor substrate 2 (IRS-2) | 5 | UniProt NCBI |
| IRS4 | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | 5 | UniProt NCBI |
| NYAP2 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | 4 | UniProt NCBI |
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | 5 | UniProt NCBI |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | 5 | UniProt NCBI |
| PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | 5 | UniProt NCBI |
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04930 | 4.18477460448e-18 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Type II diabetes mellitus |
| KEGG:04923 | 6.34946191837e-18 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Regulation of lipolysis in adipocytes |
| KEGG:04213 | 4.5497587408e-17 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Longevity regulating pathway - multiple species |
| KEGG:04211 | 1.40185062948e-15 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Longevity regulating pathway |
| WP:WP4582 | 1.41049394621e-15 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Cancer immunotherapy by CTLA4 blockade |
| REAC:R-HSA-8853659 | 2.08248884814e-15 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | RET signaling |
| GO:0097651 | 5.43463989044e-15 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | phosphatidylinositol 3-kinase complex, class I |
| GO:0005943 | 5.43463989044e-15 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | phosphatidylinositol 3-kinase complex, class IA |
| KEGG:04935 | 8.09164967654e-15 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Growth hormone synthesis, secretion and action |
| KEGG:04152 | 2.22156591023e-14 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | AMPK signaling pathway |
| KEGG:04068 | 2.22156591023e-14 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | FoxO signaling pathway |
| WP:WP3915 | 4.6697166506e-14 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Angiopoietin like protein 8 regulatory pathway |
| KEGG:04910 | 5.44372458595e-14 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Insulin signaling pathway |
| WP:WP3879 | 8.26595676852e-14 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| REAC:R-HSA-912631 | 1.01475342172e-13 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Regulation of signaling by CBL |
| REAC:R-HSA-2219530 | 1.01807865279e-13 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Constitutive Signaling by Aberrant PI3K in Cancer |
| REAC:R-HSA-912526 | 2.02855364174e-13 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Interleukin receptor SHC signaling |
| REAC:R-HSA-198203 | 2.30067923243e-13 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | PI3K/AKT activation |
| WP:WP481 | 3.00414115172e-13 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Insulin signaling |
| KEGG:04140 | 3.13028128503e-13 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Autophagy - animal |
| KEGG:04960 | 4.61741929025e-13 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Aldosterone-regulated sodium reabsorption |
| REAC:R-HSA-9027276 | 6.133394744e-13 | 0.5 | PIK3CD PIK3R1 PIK3CB IRS2 PIK3CA | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
| KEGG:04973 | 1.26074811051e-12 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Carbohydrate digestion and absorption |
| REAC:R-HSA-6811558 | 1.82631424295e-12 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| WP:WP3937 | 2.04242401848e-12 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Microglia pathogen phagocytosis pathway |
| REAC:R-HSA-2219528 | 2.21786776502e-12 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | PI3K/AKT Signaling in Cancer |
| KEGG:04931 | 2.91410162761e-12 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Insulin resistance |
| REAC:R-HSA-199418 | 3.52442079728e-12 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-451927 | 4.12876797898e-12 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Interleukin-2 family signaling |
| REAC:R-HSA-2404192 | 4.12876797898e-12 | 0.6 | IRS2 PIK3R2 PIK3R1 PIK3CB IRS4 PIK3CA | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-2428924 | 4.12876797898e-12 | 0.6 | IRS2 PIK3R2 PIK3R1 PIK3CB IRS4 PIK3CA | IGF1R signaling cascade |
| REAC:R-HSA-2428928 | 4.12876797898e-12 | 0.6 | IRS2 PIK3R2 PIK3R1 PIK3CB IRS4 PIK3CA | IRS-related events triggered by IGF1R |
| KEGG:04929 | 6.31160831245e-12 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | GnRH secretion |
| WP:WP4539 | 1.0694976103e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Synaptic signaling pathways associated with autism spectrum disorder |
| REAC:R-HSA-512988 | 1.21451913384e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| KEGG:04370 | 1.39358488379e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | VEGF signaling pathway |
| WP:WP5124 | 1.4878813345e-11 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Alzheimer 39 s disease |
| WP:WP2059 | 1.4878813345e-11 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Alzheimer 39 s disease and miRNA effects |
| KEGG:05213 | 1.57498618908e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Endometrial cancer |
| KEGG:04664 | 1.77563037976e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Fc epsilon RI signaling pathway |
| KEGG:05221 | 3.48002133815e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Acute myeloid leukemia |
| KEGG:04932 | 3.56727249483e-11 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Non-alcoholic fatty liver disease |
| REAC:R-HSA-1660499 | 3.98957347722e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Synthesis of PIPs at the plasma membrane |
| KEGG:05218 | 4.74464240801e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Melanoma |
| KEGG:04917 | 4.74464240801e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Prolactin signaling pathway |
| WP:WP4205 | 5.48114261697e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | MET in type 1 papillary renal cell carcinoma |
| WP:WP4155 | 5.48114261697e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Endometrial cancer |
| KEGG:05206 | 5.57790973406e-11 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | MicroRNAs in cancer |
| WP:WP4396 | 6.28825938835e-11 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Nonalcoholic fatty liver disease |
| KEGG:05211 | 6.37053249904e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Renal cell carcinoma |
| WP:WP5293 | 6.80248265508e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Acute myeloid leukemia |
| WP:WP4685 | 7.55653502329e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Melanoma |
| KEGG:05230 | 7.69323231147e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Central carbon metabolism in cancer |
| WP:WP1403 | 8.37891153942e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | AMP activated protein kinase signaling |
| KEGG:04662 | 8.43575175538e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | B cell receptor signaling pathway |
| KEGG:05223 | 8.43575175538e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Non-small cell lung cancer |
| KEGG:05214 | 8.43575175538e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Glioma |
| KEGG:04750 | 9.23698093868e-11 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Inflammatory mediator regulation of TRP channels |
| KEGG:01524 | 1.01005686089e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Platinum drug resistance |
| KEGG:05212 | 1.20302534778e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Pancreatic cancer |
| REAC:R-HSA-9006335 | 1.26956439264e-10 | 0.5 | PIK3CD PIK3R1 PIK3CB IRS2 PIK3CA | Signaling by Erythropoietin |
| GO:0005942 | 1.36916403995e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | phosphatidylinositol 3-kinase complex |
| KEGG:01521 | 1.42574225809e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 1.42574225809e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Chronic myeloid leukemia |
| WP:WP4255 | 1.50381489868e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Non small cell lung cancer |
| KEGG:04012 | 1.68176032964e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | ErbB signaling pathway |
| KEGG:05100 | 1.68176032964e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Bacterial invasion of epithelial cells |
| KEGG:05010 | 1.72087175048e-10 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Alzheimer disease |
| WP:WP1544 | 1.80557521105e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:05210 | 1.97494006791e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Colorectal cancer |
| KEGG:05235 | 2.30946684125e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:01522 | 2.68986841819e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Endocrine resistance |
| KEGG:04914 | 2.68986841819e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Progesterone-mediated oocyte maturation |
| KEGG:05231 | 2.89878522592e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Choline metabolism in cancer |
| KEGG:04070 | 3.35728192475e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Phosphatidylinositol signaling system |
| KEGG:04625 | 3.35728192475e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | C-type lectin receptor signaling pathway |
| KEGG:05146 | 3.60822736313e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Amoebiasis |
| KEGG:04670 | 3.60822736313e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Leukocyte transendothelial migration |
| KEGG:05222 | 3.60822736313e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Small cell lung cancer |
| KEGG:04620 | 3.87458990782e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Toll-like receptor signaling pathway |
| KEGG:04933 | 3.87458990782e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05142 | 4.15711626158e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Chagas disease |
| WP:WP4806 | 4.17677756089e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04725 | 4.4565797954e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Cholinergic synapse |
| KEGG:05215 | 4.7737811683e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Prostate cancer |
| KEGG:04666 | 4.7737811683e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Fc gamma R-mediated phagocytosis |
| WP:WP673 | 4.87437199832e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | ErbB signaling pathway |
| WP:WP4263 | 4.87437199832e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Pancreatic adenocarcinoma pathway |
| WP:WP4829 | 5.26827377139e-10 | 0.5 | PIK3R2 PIK3R1 PIK3CB PIK3R3 PIK3CA | mBDNF and proBDNF regulation of GABA neurotransmission |
| KEGG:04915 | 5.46474027343e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Estrogen signaling pathway |
| WP:WP75 | 5.66632623886e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Toll like receptor signaling pathway |
| REAC:R-HSA-1483255 | 5.77103463937e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | PI Metabolism |
| WP:WP3844 | 6.32012336923e-10 | 0.5 | PIK3R2 PIK3R1 PIK3CB PIK3R3 PIK3CA | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| KEGG:04668 | 6.65586835496e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | TNF signaling pathway |
| KEGG:04611 | 8.05554092357e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Platelet activation |
| KEGG:04066 | 8.57323049266e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | HIF-1 signaling pathway |
| WP:WP4658 | 8.71138530872e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Small cell lung cancer |
| REAC:R-HSA-109704 | 8.79412801487e-10 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | PI3K Cascade |
| REAC:R-HSA-114604 | 8.79412801487e-10 | 0.5 | PIK3R2 PIK3R1 PIK3CB PIK3R3 PIK3CA | GPVI-mediated activation cascade |
| KEGG:04722 | 9.1183064995e-10 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Neurotrophin signaling pathway |
| KEGG:04660 | 1.09294666682e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | T cell receptor signaling pathway |
| KEGG:04071 | 1.09294666682e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Sphingolipid signaling pathway |
| KEGG:04919 | 1.22957596996e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Thyroid hormone signaling pathway |
| KEGG:04926 | 1.46096469434e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Relaxin signaling pathway |
| KEGG:04650 | 1.54570454222e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Natural killer cell mediated cytotoxicity |
| REAC:R-HSA-112399 | 1.5510254452e-09 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | IRS-mediated signalling |
| WP:WP710 | 1.89450181354e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | DNA damage response only ATM dependent |
| WP:WP4787 | 2.01243328924e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Osteoblast differentiation and related diseases |
| KEGG:05135 | 2.1446853502e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Yersinia infection |
| KEGG:04380 | 2.1446853502e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Osteoclast differentiation |
| KEGG:04072 | 2.26113419915e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Phospholipase D signaling pathway |
| KEGG:05418 | 2.38279491858e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Fluid shear stress and atherosclerosis |
| KEGG:04550 | 2.78091592761e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04210 | 2.78091592761e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Apoptosis |
| WP:WP4566 | 3.31314344291e-09 | 0.5 | PIK3R2 PIK3R1 PIK3CB PIK3R3 PIK3CA | Translation inhibitors in chronically activated PDGFRA cells |
| KEGG:05162 | 3.39645455754e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Measles |
| KEGG:05017 | 3.56686159955e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Spinocerebellar ataxia |
| KEGG:05224 | 3.92906024112e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Breast cancer |
| REAC:R-HSA-74751 | 4.09612895943e-09 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | Insulin receptor signalling cascade |
| WP:WP3932 | 4.2115265291e-09 | 0.7 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP4217 | 4.41989421211e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Ebola virus infection in host |
| KEGG:05226 | 4.74565176035e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Gastric cancer |
| KEGG:04630 | 4.74565176035e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | JAK-STAT signaling pathway |
| KEGG:05160 | 4.74565176035e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Hepatitis C |
| REAC:R-HSA-9673770 | 5.59469274597e-09 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Signaling by PDGFRA extracellular domain mutants |
| REAC:R-HSA-2730905 | 5.59469274597e-09 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Role of LAT2/NTAL/LAB on calcium mobilization |
| REAC:R-HSA-9673767 | 5.59469274597e-09 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants |
| WP:WP3929 | 5.71818690555e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Chemokine signaling pathway |
| REAC:R-HSA-1257604 | 6.07797051488e-09 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | PIP3 activates AKT signaling |
| WP:WP4630 | 6.31937696482e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Measles virus infection |
| WP:WP395 | 6.77003788383e-09 | 0.5 | PIK3CD PIK3R2 PIK3CA PIK3R1 IRS2 | IL 4 signaling pathway |
| KEGG:04062 | 6.80578006979e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Chemokine signaling pathway |
| KEGG:04218 | 7.1088354414e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Cellular senescence |
| WP:WP51 | 8.05604241301e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Regulation of actin cytoskeleton |
| GO:0046854 | 8.25841709785e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | phosphatidylinositol phosphate biosynthetic process |
| KEGG:05164 | 8.43570362104e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Influenza A |
| WP:WP4239 | 9.71588010752e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:05161 | 9.96230956546e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Hepatitis B |
| KEGG:04150 | 9.96230956546e-09 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | mTOR signaling pathway |
| KEGG:04613 | 1.03778532605e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Neutrophil extracellular trap formation |
| WP:WP4666 | 1.21814921345e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Hepatitis B infection |
| KEGG:04360 | 1.26781327742e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Axon guidance |
| KEGG:04024 | 1.48101393871e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | cAMP signaling pathway |
| KEGG:05225 | 1.53872866551e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Hepatocellular carcinoma |
| REAC:R-HSA-9006925 | 1.64795681806e-08 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Intracellular signaling by second messengers |
| KEGG:05207 | 1.78863866863e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Chemical carcinogenesis - receptor activation |
| WP:WP4223 | 1.86885208881e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Ras signaling |
| KEGG:04015 | 1.99744952904e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Rap1 signaling pathway |
| KEGG:05167 | 2.14760788608e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04510 | 2.56452539475e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Focal adhesion |
| KEGG:05417 | 3.25942261293e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Lipid and atherosclerosis |
| KEGG:05169 | 3.25942261293e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Epstein-Barr virus infection |
| KEGG:05415 | 3.48444869334e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Diabetic cardiomyopathy |
| KEGG:05205 | 3.48444869334e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Proteoglycans in cancer |
| REAC:R-HSA-210993 | 3.63057874925e-08 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Tie2 Signaling |
| KEGG:04014 | 3.72223551846e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Ras signaling pathway |
| KEGG:05203 | 3.97335247937e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Viral carcinogenesis |
| WP:WP2037 | 4.23809234583e-08 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | Prolactin signaling pathway |
| KEGG:05163 | 4.81266008356e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Human cytomegalovirus infection |
| KEGG:05170 | 4.96589922833e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Human immunodeficiency virus 1 infection |
| WP:WP306 | 5.01294038777e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Focal adhesion |
| KEGG:04810 | 5.28455710474e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Regulation of actin cytoskeleton |
| KEGG:05166 | 5.79427163296e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-9670439 | 6.32607926503e-08 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants |
| REAC:R-HSA-9671555 | 6.32607926503e-08 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Signaling by PDGFR in disease |
| REAC:R-HSA-9669938 | 6.32607926503e-08 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | Signaling by KIT in disease |
| KEGG:05171 | 6.53683467398e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Coronavirus disease - COVID-19 |
| KEGG:05208 | 6.53683467398e-08 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-74752 | 6.97887101048e-08 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | Signaling by Insulin receptor |
| GO:0052742 | 7.59619890697e-08 | 0.5 | PIK3CD PIK3R1 PIK3CB PIK3R3 PIK3CA | phosphatidylinositol kinase activity |
| WP:WP2261 | 8.64559787267e-08 | 0.5 | PIK3CD PIK3R2 PIK3CB PIK3R1 PIK3CA | Glioblastoma signaling pathways |
| REAC:R-HSA-389357 | 1.28653942882e-07 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | CD28 dependent PI3K/Akt signaling |
| KEGG:05131 | 1.31962455415e-07 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Shigellosis |
| REAC:R-HSA-1483257 | 1.36499891333e-07 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Phospholipid metabolism |
| REAC:R-HSA-373753 | 1.58873212508e-07 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Nephrin family interactions |
| REAC:R-HSA-2029485 | 1.58873212508e-07 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Role of phospholipids in phagocytosis |
| REAC:R-HSA-5663202 | 1.74337360231e-07 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Diseases of signal transduction by growth factor receptors and second messengers |
| REAC:R-HSA-2424491 | 1.94114532425e-07 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | DAP12 signaling |
| REAC:R-HSA-201556 | 1.94114532425e-07 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Signaling by ALK |
| KEGG:05020 | 2.08725384017e-07 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Prion disease |
| GO:0008286 | 2.29330057336e-07 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | insulin receptor signaling pathway |
| GO:0043491 | 2.70106752024e-07 | 0.7 | PIK3CD PIK3CB PIK3R2 NYAP2 PIK3R1 PIK3R3 PIK3CA | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| REAC:R-HSA-449147 | 2.74925139305e-07 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Signaling by Interleukins |
| GO:0016303 | 3.86287613381e-07 | 0.4 | PIK3CD PIK3CB PIK3R3 PIK3CA | 1-phosphatidylinositol-3-kinase activity |
| REAC:R-HSA-186763 | 3.96199240718e-07 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Downstream signal transduction |
| WP:WP524 | 4.40874253788e-07 | 0.4 | PIK3CD PIK3R2 PIK3CB PIK3CA | G13 signaling pathway |
| WP:WP4564 | 4.99493133915e-07 | 0.4 | PIK3CD PIK3CB PIK3R3 PIK3CA | Neural crest cell migration during development |
| REAC:R-HSA-9006934 | 5.04424839513e-07 | 0.7 | IRS2 PIK3R2 PIK3R1 PIK3CB IRS4 PIK3CA PIK3R3 | Signaling by Receptor Tyrosine Kinases |
| KEGG:04151 | 5.27716680937e-07 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | PI3K-Akt signaling pathway |
| WP:WP5420 | 5.96359325399e-07 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | ADHD and autism ASD linked metabolic pathways and SNP |
| KEGG:05165 | 6.22426346927e-07 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Human papillomavirus infection |
| REAC:R-HSA-2172127 | 6.28819246487e-07 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | DAP12 interactions |
| REAC:R-HSA-389356 | 6.28819246487e-07 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | CD28 co-stimulation |
| WP:WP4565 | 6.34019510892e-07 | 0.4 | PIK3CD PIK3CB PIK3R3 PIK3CA | Neural crest cell migration in cancer |
| REAC:R-HSA-187037 | 6.88110002678e-07 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | Signaling by NTRK1 (TRKA) |
| WP:WP4172 | 7.47103075376e-07 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | PI3K Akt signaling pathway |
| GO:0001727 | 8.47898694602e-07 | 0.5 | PIK3CD PIK3R1 PIK3CB PIK3R3 PIK3CA | lipid kinase activity |
| GO:0007169 | 8.97065168614e-07 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | transmembrane receptor protein tyrosine kinase signaling pathway |
| REAC:R-HSA-1266695 | 9.51119385451e-07 | 0.4 | PIK3R2 PIK3R1 IRS2 PIK3R3 | Interleukin-7 signaling |
| REAC:R-HSA-422475 | 1.08129399358e-06 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Axon guidance |
| GO:0006661 | 1.37046481804e-06 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | phosphatidylinositol biosynthetic process |
| WP:WP4262 | 1.38398941122e-06 | 0.5 | PIK3CD PIK3R1 PIK3CA PIK3R3 PIK3R2 | Breast cancer pathway |
| REAC:R-HSA-9675108 | 1.39523206855e-06 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Nervous system development |
| REAC:R-HSA-1433557 | 1.55595126345e-06 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | Signaling by SCF-KIT |
| REAC:R-HSA-166520 | 1.55984309501e-06 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | Signaling by NTRKs |
| WP:WP5191 | 1.90315557518e-06 | 0.3 | PIK3CD PIK3CB PIK3CA | Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution |
| KEGG:05168 | 2.33820062976e-06 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Herpes simplex virus 1 infection |
| WP:WP585 | 2.67653318161e-06 | 0.4 | PIK3CD PIK3R1 IRS2 PIK3R2 | Interferon type I signaling pathways |
| GO:0046488 | 3.54189356835e-06 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | phosphatidylinositol metabolic process |
| GO:0032869 | 4.93566709462e-06 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | cellular response to insulin stimulus |
| REAC:R-HSA-186797 | 5.11949202063e-06 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Signaling by PDGF |
| REAC:R-HSA-1280215 | 5.47876283954e-06 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Cytokine Signaling in Immune system |
| GO:0019898 | 7.3710670408e-06 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | extrinsic component of membrane |
| KEGG:05200 | 7.44447080414e-06 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Pathways in cancer |
| GO:0032868 | 7.69444144394e-06 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | response to insulin |
| WP:WP4674 | 9.75906330525e-06 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Head and neck squamous cell carcinoma |
| REAC:R-HSA-388841 | 1.0362148401e-05 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | Costimulation by the CD28 family |
| WP:WP3935 | 1.26558191028e-05 | 0.3 | IRS4 IRS2 PIK3R3 | Leptin insulin signaling overlap |
| REAC:R-HSA-9009391 | 1.46096587181e-05 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | Extra-nuclear estrogen signaling |
| GO:0046474 | 2.05689829214e-05 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | glycerophospholipid biosynthetic process |
| WP:WP4483 | 2.57266083477e-05 | 0.3 | PIK3CD PIK3CB PIK3CA | Relationship between inflammation COX 2 and EGFR |
| GO:0007167 | 2.66393566084e-05 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | enzyme-linked receptor protein signaling pathway |
| GO:0071375 | 2.92399691122e-05 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | cellular response to peptide hormone stimulus |
| CORUM:3133 | 3.07577115383e-05 | 0.2 | PIK3R1 PIK3CA | Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) |
| REAC:R-HSA-5673001 | 3.59886236317e-05 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | RAF/MAP kinase cascade |
| REAC:R-HSA-2029480 | 3.71608649487e-05 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-5684996 | 3.94862843411e-05 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | MAPK1/MAPK3 signaling |
| REAC:R-HSA-76002 | 3.94862843411e-05 | 0.5 | PIK3R2 PIK3R1 PIK3CB PIK3R3 PIK3CA | Platelet activation, signaling and aggregation |
| GO:0008654 | 4.48632234294e-05 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | phospholipid biosynthetic process |
| REAC:R-HSA-9013404 | 4.77943696984e-05 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | RAC2 GTPase cycle |
| WP:WP4659 | 5.02950108205e-05 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | Gastrin signaling pathway |
| GO:0045017 | 5.58068044705e-05 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | glycerolipid biosynthetic process |
| REAC:R-HSA-1266738 | 5.63547316939e-05 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Developmental Biology |
| REAC:R-HSA-4420097 | 5.78166491583e-05 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-202424 | 6.33783538488e-05 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Downstream TCR signaling |
| WP:WP2533 | 6.5843121313e-05 | 0.3 | PIK3CD PIK3CB PIK3CA | Glycerophospholipid biosynthetic pathway |
| WP:WP4481 | 7.37177804475e-05 | 0.3 | PIK3CD PIK3CB PIK3CA | Resistin as a regulator of inflammation |
| GO:0043434 | 7.74314584452e-05 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | response to peptide hormone |
| REAC:R-HSA-5683057 | 7.8296099745e-05 | 0.5 | PIK3R2 PIK3R1 PIK3CB IRS2 PIK3CA | MAPK family signaling cascades |
| REAC:R-HSA-194138 | 8.24732991588e-05 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Signaling by VEGF |
| GO:1901653 | 8.44065502775e-05 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | cellular response to peptide |
| REAC:R-HSA-202733 | 0.000109836051439 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Cell surface interactions at the vascular wall |
| WP:WP4871 | 0.0001114513301 | 0.3 | PIK3CD PIK3CB PIK3CA | Kisspeptin kisspeptin receptor system in the ovary |
| WP:WP244 | 0.0001114513301 | 0.3 | PIK3R2 IRS2 PIK3R1 | Alpha 6 beta 4 signaling pathway |
| REAC:R-HSA-1500931 | 0.000114236170736 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Cell-Cell communication |
| GO:0035005 | 0.000115261178119 | 0.3 | PIK3CD PIK3CB PIK3CA | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| REAC:R-HSA-202403 | 0.000128227342776 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | TCR signaling |
| REAC:R-HSA-2454202 | 0.000154334891201 | 0.4 | PIK3R2 PIK3R1 PIK3CB PIK3CA | Fc epsilon receptor (FCERI) signaling |
| GO:0006650 | 0.000161368489345 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | glycerophospholipid metabolic process |
| REAC:R-HSA-9680350 | 0.000180911267958 | 0.3 | PIK3R1 PIK3CB PIK3CA | Signaling by CSF1 (M-CSF) in myeloid cells |
| REAC:R-HSA-556833 | 0.000231143371219 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Metabolism of lipids |
| GO:1901652 | 0.000251349486236 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | response to peptide |
| WP:WP5411 | 0.000257029627199 | 0.3 | PIK3CD PIK3CB PIK3CA | Phosphatidyl inositol phosphate pathway |
| WP:WP286 | 0.000257029627199 | 0.3 | PIK3CD PIK3R1 PIK3R2 | IL 3 signaling pathway |
| WP:WP4971 | 0.000257029627199 | 0.3 | PIK3CD PIK3CB PIK3CA | Phosphoinositides metabolism |
| GO:0071495 | 0.000261844325434 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | cellular response to endogenous stimulus |
| REAC:R-HSA-416476 | 0.000299946729968 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | G alpha (q) signalling events |
| REAC:R-HSA-1280218 | 0.000373017332655 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Adaptive Immune System |
| HP:0030381 | 0.000413118282426 | 0.2 | PIK3CD PIK3R1 | Increased proportion of transitional B cells |
| HP:0030379 | 0.000413118282426 | 0.2 | PIK3CD PIK3R1 | Abnormal proportion of transitional B cells |
| GO:0061695 | 0.000423454860605 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | transferase complex, transferring phosphorus-containing groups |
| KEGG:00562 | 0.000496184652725 | 0.3 | PIK3CD PIK3CB PIK3CA | Inositol phosphate metabolism |
| GO:0009719 | 0.000515043363363 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | response to endogenous stimulus |
| GO:0006644 | 0.000535084189945 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | phospholipid metabolic process |
| GO:0046486 | 0.000581286880302 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | glycerolipid metabolic process |
| WP:WP2032 | 0.000584642906818 | 0.3 | PIK3R2 PIK3CA PIK3R1 | Thyroid stimulating hormone TSH signaling pathway |
| REAC:R-HSA-9013149 | 0.000634112853678 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | RAC1 GTPase cycle |
| GO:0042113 | 0.00101275824992 | 0.5 | PIK3CD PIK3R1 IRS2 PIK3R3 PIK3R2 | B cell activation |
| REAC:R-HSA-9028335 | 0.00101671361746 | 0.2 | PIK3R1 PIK3CA | Activated NTRK2 signals through PI3K |
| REAC:R-HSA-8851907 | 0.00101671361746 | 0.2 | PIK3R1 PIK3CA | MET activates PI3K/AKT signaling |
| REAC:R-HSA-162582 | 0.00111876797815 | 0.8 | IRS2 PIK3R2 PIK3CD PIK3CB IRS4 PIK3CA PIK3R1 PIK3R3 | Signal Transduction |
| REAC:R-HSA-8939211 | 0.001187913262 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | ESR-mediated signaling |
| HP:0011956 | 0.00123890251767 | 0.2 | PIK3CD PIK3R1 | Intestinal lymphoid nodular hyperplasia |
| GO:0071417 | 0.00132424915889 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | cellular response to organonitrogen compound |
| GO:0036092 | 0.00138065085968 | 0.3 | PIK3CD PIK3CB PIK3CA | phosphatidylinositol-3-phosphate biosynthetic process |
| GO:0001775 | 0.001481792513 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | cell activation |
| REAC:R-HSA-9603381 | 0.00152451380898 | 0.2 | PIK3R1 PIK3CA | Activated NTRK3 signals through PI3K |
| GO:0032870 | 0.00175040635763 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | cellular response to hormone stimulus |
| REAC:R-HSA-1250342 | 0.00213354034849 | 0.2 | PIK3R1 PIK3CA | PI3K events in ERBB4 signaling |
| REAC:R-HSA-1643685 | 0.00242417119418 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Disease |
| GO:1901699 | 0.00281183056957 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | cellular response to nitrogen compound |
| REAC:R-HSA-5655291 | 0.00284368219242 | 0.2 | PIK3R1 PIK3CA | Signaling by FGFR4 in disease |
| REAC:R-HSA-109582 | 0.00307561721656 | 0.5 | PIK3R2 PIK3R1 PIK3CB PIK3R3 PIK3CA | Hemostasis |
| GO:0044255 | 0.00343644924349 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | cellular lipid metabolic process |
| REAC:R-HSA-9006931 | 0.0037284813176 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | Signaling by Nuclear Receptors |
| WP:WP22 | 0.00375768007348 | 0.2 | PIK3R2 PIK3R1 | IL 9 signaling pathway |
| GO:0046935 | 0.00418195709292 | 0.3 | PIK3R2 PIK3R1 PIK3R3 | 1-phosphatidylinositol-3-kinase regulator activity |
| REAC:R-HSA-1963642 | 0.00456686801865 | 0.2 | PIK3R1 PIK3CA | PI3K events in ERBB2 signaling |
| REAC:R-HSA-5654710 | 0.00456686801865 | 0.2 | PIK3R1 PIK3CA | PI-3K cascade:FGFR3 |
| GO:0009725 | 0.00489105509169 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | response to hormone |
| REAC:R-HSA-5654689 | 0.00557969031297 | 0.2 | PIK3R1 PIK3CA | PI-3K cascade:FGFR1 |
| WP:WP205 | 0.00560972640403 | 0.2 | PIK3R2 PIK3R1 | IL 7 signaling pathway |
| REAC:R-HSA-168256 | 0.00569735174379 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | Immune System |
| GO:0090407 | 0.00603519205703 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | organophosphate biosynthetic process |
| HP:0031693 | 0.0061877325188 | 0.2 | PIK3CD PIK3R1 | Severe Epstein Barr virus infection |
| WP:WP2380 | 0.00658064183178 | 0.3 | PIK3R2 IRS2 PIK3R1 | Brain derived neurotrophic factor BDNF signaling pathway |
| REAC:R-HSA-5637812 | 0.00669318453569 | 0.2 | PIK3R1 PIK3CA | Signaling by EGFRvIII in Cancer |
| REAC:R-HSA-5654720 | 0.00669318453569 | 0.2 | PIK3R1 PIK3CA | PI-3K cascade:FGFR4 |
| REAC:R-HSA-5654695 | 0.00669318453569 | 0.2 | PIK3R1 PIK3CA | PI-3K cascade:FGFR2 |
| REAC:R-HSA-5637810 | 0.00669318453569 | 0.2 | PIK3R1 PIK3CA | Constitutive Signaling by EGFRvIII |
| GO:0046649 | 0.00700796677905 | 0.6 | IRS2 PIK3CD PIK3R2 PIK3CA PIK3R1 PIK3R3 | lymphocyte activation |
| REAC:R-HSA-9665348 | 0.00790724004214 | 0.2 | PIK3R1 PIK3CA | Signaling by ERBB2 ECD mutants |
| REAC:R-HSA-9703648 | 0.00790724004214 | 0.2 | PIK3R1 PIK3CA | Signaling by FLT3 ITD and TKD mutants |
| REAC:R-HSA-9034015 | 0.00790724004214 | 0.2 | PIK3R1 PIK3CA | Signaling by NTRK3 (TRKC) |
| WP:WP5181 | 0.00864943763047 | 0.2 | PIK3R1 IRS2 | Roles of ceramides in development of insulin resistance |
| GO:0010243 | 0.00876412752475 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | response to organonitrogen compound |
| REAC:R-HSA-5654708 | 0.00922174626729 | 0.2 | PIK3R1 PIK3CA | Downstream signaling of activated FGFR3 |
| REAC:R-HSA-180292 | 0.00922174626729 | 0.2 | PIK3R1 PIK3CA | GAB1 signalosome |
| REAC:R-HSA-5655332 | 0.00922174626729 | 0.2 | PIK3R1 PIK3CA | Signaling by FGFR3 in disease |
| GO:0005158 | 0.00936146543831 | 0.3 | IRS4 IRS2 PIK3R1 | insulin receptor binding |
| GO:0030183 | 0.00941974755121 | 0.4 | PIK3CD PIK3R1 PIK3R3 PIK3R2 | B cell differentiation |
| GO:0043548 | 0.0111127441894 | 0.3 | IRS4 IRS2 PIK3R1 | phosphatidylinositol 3-kinase binding |
| REAC:R-HSA-5637815 | 0.0121516690115 | 0.2 | PIK3R1 PIK3CA | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| REAC:R-HSA-5654716 | 0.0121516690115 | 0.2 | PIK3R1 PIK3CA | Downstream signaling of activated FGFR4 |
| REAC:R-HSA-1839117 | 0.0121516690115 | 0.2 | PIK3R1 PIK3CA | Signaling by cytosolic FGFR1 fusion mutants |
| REAC:R-HSA-1236382 | 0.0121516690115 | 0.2 | PIK3R1 PIK3CA | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| REAC:R-HSA-9703465 | 0.0121516690115 | 0.2 | PIK3R1 PIK3CA | Signaling by FLT3 fusion proteins |
| REAC:R-HSA-5654687 | 0.0121516690115 | 0.2 | PIK3R1 PIK3CA | Downstream signaling of activated FGFR1 |
| REAC:R-HSA-5654696 | 0.0121516690115 | 0.2 | PIK3R1 PIK3CA | Downstream signaling of activated FGFR2 |
| WP:WP3972 | 0.0133616217617 | 0.2 | PIK3R1 PIK3CA | PDGFR beta pathway |
| REAC:R-HSA-9664565 | 0.0154820698392 | 0.2 | PIK3R1 PIK3CA | Signaling by ERBB2 KD Mutants |
| REAC:R-HSA-9006115 | 0.0154820698392 | 0.2 | PIK3R1 PIK3CA | Signaling by NTRK2 (TRKB) |
| GO:0006629 | 0.0154846744626 | 0.7 | IRS2 PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | lipid metabolic process |
| GO:0008610 | 0.0163434963921 | 0.6 | PIK3CD PIK3CB PIK3R2 PIK3CA PIK3R1 PIK3R3 | lipid biosynthetic process |
| REAC:R-HSA-1227990 | 0.0172971739669 | 0.2 | PIK3R1 PIK3CA | Signaling by ERBB2 in Cancer |
| REAC:R-HSA-388396 | 0.0176009385409 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | GPCR downstream signalling |
| HP:0031692 | 0.0185361113698 | 0.2 | PIK3CD PIK3R1 | Severe cytomegalovirus infection |
| HP:0011110 | 0.0185361113698 | 0.2 | PIK3CD PIK3R1 | Recurrent tonsillitis |
| HP:0200117 | 0.0185361113698 | 0.2 | PIK3CD PIK3R1 | Recurrent upper and lower respiratory tract infections |
| HP:0025352 | 0.0185361113698 | 0.2 | PIK3R2 PIK3CA | Typically de novo |
| WP:WP127 | 0.0190825311458 | 0.2 | PIK3R2 PIK3R1 | IL 5 signaling pathway |
| KEGG:05132 | 0.0198241007008 | 0.3 | PIK3CD PIK3CB PIK3CA | Salmonella infection |
| GO:1901698 | 0.0202827628199 | 0.6 | IRS2 PIK3R2 PIK3R1 IRS4 PIK3CA PIK3R3 | response to nitrogen compound |
| REAC:R-HSA-1643713 | 0.0212266392091 | 0.2 | PIK3R1 PIK3CA | Signaling by EGFR in Cancer |
| GO:0045321 | 0.0229009489705 | 0.6 | IRS2 PIK3CD PIK3R2 PIK3CA PIK3R1 PIK3R3 | leukocyte activation |
| REAC:R-HSA-9012999 | 0.023196899709 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | RHO GTPase cycle |
| REAC:R-HSA-983695 | 0.0233407803855 | 0.2 | PIK3CD PIK3R1 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| WP:WP2828 | 0.0243817991122 | 0.2 | PIK3R2 PIK3R1 | Bladder cancer |
| WP:WP4558 | 0.0243817991122 | 0.2 | PIK3R1 PIK3CA | Overview of interferons mediated signaling pathway |
| REAC:R-HSA-9682385 | 0.0278673305979 | 0.2 | PIK3R1 PIK3CA | FLT3 signaling in disease |
| REAC:R-HSA-1839124 | 0.0278673305979 | 0.2 | PIK3R1 PIK3CA | FGFR1 mutant receptor activation |
| WP:WP2332 | 0.0287758668954 | 0.2 | PIK3R2 PIK3R1 | Interleukin 11 signaling pathway |
| REAC:R-HSA-372790 | 0.0291774485596 | 0.4 | PIK3R2 PIK3R1 PIK3CA PIK3R3 | Signaling by GPCR |
| WP:WP364 | 0.030320246882 | 0.2 | PIK3R2 PIK3R1 | IL6 signaling pathway |
| HP:0032170 | 0.0320940919357 | 0.2 | PIK3CD PIK3R1 | Severe varicella zoster infection |
| REAC:R-HSA-5654741 | 0.0381104316433 | 0.2 | PIK3R1 PIK3CA | Signaling by FGFR3 |
| WP:WP61 | 0.0386378382776 | 0.2 | PIK3R2 PIK3R1 | Notch signaling pathway |
| KEGG:04920 | 0.0405252221107 | 0.2 | IRS4 IRS2 | Adipocytokine signaling pathway |
| REAC:R-HSA-5654743 | 0.0409184848695 | 0.2 | PIK3R1 PIK3CA | Signaling by FGFR4 |
| REAC:R-HSA-5655302 | 0.0409184848695 | 0.2 | PIK3R1 PIK3CA | Signaling by FGFR1 in disease |
| WP:WP2018 | 0.0422420407673 | 0.2 | PIK3R2 PIK3R1 | RANKL RANK signaling pathway |
| WP:WP195 | 0.0460040954064 | 0.2 | PIK3R2 PIK3R1 | IL 1 signaling pathway |
| REAC:R-HSA-5655253 | 0.0468305595269 | 0.2 | PIK3R1 PIK3CA | Signaling by FGFR2 in disease |
| REAC:R-HSA-5654736 | 0.0499343626014 | 0.2 | PIK3R1 PIK3CA | Signaling by FGFR1 |
| REAC:R-HSA-9607240 | 0.0499343626014 | 0.2 | PIK3R1 PIK3CA | FLT3 Signaling |
| CORUM:2574 | 0.0499436884912 | 0.1 | PIK3R1 | CD19-VAV1-PIK3R1 complex |
| CORUM:7361 | 0.0499436884912 | 0.1 | PIK3R1 | ARAF-PIK3R1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIK3CA | PIK3R3 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | ||
| PIK3CB | PIK3R1 | 0.999 | 0.23 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () fraction | |
| PIK3CB | PIK3R3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PIK3CA | PIK3R1 | 0.998 | 0.164 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PIK3CA | PIK3R2 | 0.998 | 0.295459408904 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PIK3CD | PIK3R3 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIK3CD | PIK3R1 | 0.997 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PIK3CB | PIK3CA | 0.996 | 0.21 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3R2 | PIK3R1 | 0.995 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| PIK3R2 | PIK3R3 | 0.994 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| IRS2 | PIK3R1 | 0.993 | 0.202 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| PIK3CB | PIK3R2 | 0.992 | 0.350883495146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IRS2 | PIK3CD | 0.979 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3R3 | PIK3R1 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| IRS2 | PIK3CB | 0.954 | 0.238 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3CA | IRS4 | 0.932 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| PIK3CB | UBQLNL | 0.916 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PIK3CB | IRS4 | 0.913 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| PIK3CA | PIK3CD | 0.869 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| IRS2 | PIK3R3 | 0.868 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IRS2 | PIK3CA | 0.842 | 0.212 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3CB | PIK3CD | 0.838 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NYAP2 | PIK3R1 | 0.8 | hein_WMM hein () | ||
| PIK3R3 | IRS4 | 0.56 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| PIK3R1 | IRS4 | 0.481 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | ||
| PIK3R2 | IRS4 | 0.321 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM | ||
| NYAP2 | PIK3CD | 0.248 | hein_WMM WMM_only | ||
| NYAP2 | PIK3CB | 0.248 | hein_WMM WMM_only | ||
| NYAP2 | IRS2 | 0.232 | hein_WMM WMM_only | ||
| NYAP2 | PIK3CA | 0.192 | hein_WMM WMM_only | ||
| PIK3CD | IRS4 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIK3CD | PIK3R2 | 0.141 | 0.13 |
mutually_exclusive (Q92569)
|
bioplex_WMM bioplex3_WMM WMM_only |
| PIK3R2 | UBQLNL | 0.065 | bioplex3_WMM WMM_only | ||
| PIK3R1 | UBQLNL | 0.065 | bioplex3_WMM WMM_only | ||
| PIK3R3 | UBQLNL | 0.064 | bioplex3_WMM WMM_only | ||
| IRS2 | PIK3R2 | 0.041 | 0.342519858782 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NYAP2 | IRS4 | 0.027 | bioplex3_HEK293 WMM_only | ||
| UBQLNL | IRS4 | 0.021 | bioplex3_WMM WMM_only | ||
| IRS2 | IRS4 | 0.02 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM |
Related Complexes