hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11642.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ECSCR | Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2) | 5 | UniProt NCBI |
| VMA21 | Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein) | 5 | UniProt NCBI |
| AQP5 | Aquaporin-5 (AQP-5) | 5 | UniProt NCBI |
| ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | 5 | UniProt NCBI |
| ATP6V0E1 | V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 0.00114674441138 | 0.4 | ATP6V0A2 ATP6V0E1 | Collecting duct acid secretion |
| KEGG:05110 | 0.00447375439216 | 0.4 | ATP6V0A2 ATP6V0E1 | Vibrio cholerae infection |
| REAC:R-HSA-77387 | 0.00572567861867 | 0.4 | ATP6V0A2 ATP6V0E1 | Insulin receptor recycling |
| REAC:R-HSA-917977 | 0.00572567861867 | 0.4 | ATP6V0A2 ATP6V0E1 | Transferrin endocytosis and recycling |
| REAC:R-HSA-1222556 | 0.00704059925156 | 0.4 | ATP6V0A2 ATP6V0E1 | ROS and RNS production in phagocytes |
| KEGG:04721 | 0.00798209753112 | 0.4 | ATP6V0A2 ATP6V0E1 | Synaptic vesicle cycle |
| KEGG:05120 | 0.0088037421881 | 0.4 | ATP6V0A2 ATP6V0E1 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:05323 | 0.0102617382696 | 0.4 | ATP6V0A2 ATP6V0E1 | Rheumatoid arthritis |
| REAC:R-HSA-917937 | 0.0200193611976 | 0.4 | ATP6V0A2 ATP6V0E1 | Iron uptake and transport |
| REAC:R-HSA-74752 | 0.0285103583123 | 0.4 | ATP6V0A2 ATP6V0E1 | Signaling by Insulin receptor |
| KEGG:00190 | 0.0330036745401 | 0.4 | ATP6V0A2 ATP6V0E1 | Oxidative phosphorylation |
| KEGG:04145 | 0.038606937256 | 0.4 | ATP6V0A2 ATP6V0E1 | Phagosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VMA21 | ATP6V0A2 | 1.0 | 0.008 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| ATP6V0E1 | ATP6V0A2 | 0.966 | bioplex3_HEK293 bioplex () | |
| ATP6V0A2 | AQP5 | 0.954 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VMA21 | ATP6V0E1 | 0.91 | bioplex3_HEK293 bioplex () | |
| VMA21 | ECSCR | 0.891 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes