hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11651.1
Complex Portal: CPX-22415
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM230 | Transmembrane protein 230 | 5 | UniProt NCBI |
| CRYL1 | Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) | 5 | UniProt NCBI |
| F2R | Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor) | 5 | UniProt NCBI |
| USP30 | Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) | 5 | UniProt NCBI |
| DSTYK | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | 5 | UniProt NCBI |
| GRPR | Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor) | 5 | UniProt NCBI |
| ATP8B4 | Probable phospholipid-transporting ATPase IM (EC 7.6.2.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5405 | 0.0294502955092 | 0.166666666667 | CRYL1 | 13q12 or CRYL1 copy number variation |
| HPA:0100203 | 0.0317600025572 | 0.5 | CRYL1 DSTYK USP30 | cerebral cortex; endothelial cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GRPR | TMEM230 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GRPR | USP30 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GRPR | F2R | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TMEM230 | ATP8B4 | 0.95 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DSTYK | GRPR | 0.852 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| F2R | CRYL1 | 0.845 | 0.058 | bioplex3_HEK293 bioplex () | |
| DSTYK | USP30 | 0.226 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP30 | F2R | 0.18 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| F2R | TMEM230 | 0.172 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| DSTYK | F2R | 0.158 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| DSTYK | TMEM230 | 0.131 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP30 | TMEM230 | 0.105 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes