hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11655.1
Complex Portal: CPX-19880
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IFIH1 | Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) | 5 | UniProt NCBI |
| TALDO1 | Transaldolase (EC 2.2.1.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001876 | 0.0208639809935 | 1.0 | IFIH1 TALDO1 | Pancytopenia |
| REAC:R-HSA-6791462 | 0.0249718442457 | 0.5 | TALDO1 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P |
| REAC:R-HSA-6791055 | 0.0249718442457 | 0.5 | TALDO1 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P |
| HP:0001433 | 0.030911500096 | 1.0 | IFIH1 TALDO1 | Hepatosplenomegaly |
| WP:WP5187 | 0.0373151717536 | 0.5 | IFIH1 | mRNA vaccine activation of dendritic cell and induction of IFN 1 |
| HP:0012145 | 0.0397389633075 | 1.0 | IFIH1 TALDO1 | Abnormality of multiple cell lineages in the bone marrow |
| WP:WP134 | 0.0435328773163 | 0.5 | TALDO1 | Pentose phosphate metabolism |
| HP:0001562 | 0.0440177027348 | 1.0 | IFIH1 TALDO1 | Oligohydramnios |
| WP:WP5043 | 0.049750157242 | 0.5 | TALDO1 | Pentose phosphate pathway in senescent cells |
| REAC:R-HSA-163754 | 0.0499419797295 | 0.5 | TALDO1 | Insulin effects increased synthesis of Xylulose-5-Phosphate |
| REAC:R-HSA-6791465 | 0.0499419797295 | 0.5 | TALDO1 | Pentose phosphate pathway disease |
| HP:0006112 | 0.0499436884913 | 0.5 | IFIH1 | Expanded phalanges with widened medullary cavities |
| HP:0006386 | 0.0499436884913 | 0.5 | IFIH1 | Hypoplastic distal radial epiphyses |
| HP:0008102 | 0.0499436884913 | 0.5 | IFIH1 | Expanded metatarsals with widened medullary cavities |
| HP:0010597 | 0.0499436884913 | 0.5 | IFIH1 | Abnormality of the distal radial epiphysis |
| HP:0005303 | 0.0499436884913 | 0.5 | IFIH1 | Aortic arch calcification |
| HP:0032137 | 0.0499436884913 | 0.5 | IFIH1 | Decreased circulating IgG3 level |
| HP:0032296 | 0.0499436884913 | 0.5 | IFIH1 | Increased circulating IgG subclass |
| HP:0032297 | 0.0499436884913 | 0.5 | IFIH1 | Increased circulating IgG3 level |
| HP:0033214 | 0.0499436884913 | 0.5 | IFIH1 | Recurrent viral pneumonia |
| HP:0006232 | 0.0499436884913 | 0.5 | IFIH1 | Expanded metacarpals with widened medullary cavities |
| HP:0006353 | 0.0499436884913 | 0.5 | IFIH1 | Hypoplasia of the tooth germ |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IFIH1 | TALDO1 | 0.801 | 0.208 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| IFIH1 | huMAP3_11655.1 huMAP3_14906.1 |
| TALDO1 | huMAP3_11655.1 huMAP3_14906.1 |