hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11658.1
Complex Portal: CPX-11860
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG16L2 | Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) | 4 | UniProt NCBI |
| ATG16L1 | Autophagy-related protein 16-1 (APG16-like 1) | 5 | UniProt NCBI |
| ARHGAP5 | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | 5 | UniProt NCBI |
| ATG12 | Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) | 5 | UniProt NCBI |
| TECPR1 | Tectonin beta-propeller repeat-containing protein 1 | 5 | UniProt NCBI |
| ATG5 | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) | 5 | UniProt NCBI |
| ATG3 | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | 5 | UniProt NCBI |
| KAZN | Kazrin | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0034274 | 3.02495762709e-12 | 0.625 | ATG16L2 ATG12 ATG5 ATG3 ATG16L1 | Atg12-Atg5-Atg16 complex |
| WP:WP4863 | 7.86637744935e-12 | 0.625 | ATG16L2 ATG12 ATG5 ATG3 ATG16L1 | Host pathogen interaction of human coronaviruses autophagy |
| WP:WP2509 | 2.44896800551e-08 | 0.5 | ATG16L1 ATG5 ATG3 ATG12 | Nanoparticle triggered autophagic cell death |
| KEGG:04136 | 4.9693086795e-08 | 0.5 | ATG16L1 ATG5 ATG3 ATG12 | Autophagy - other |
| WP:WP4923 | 6.8457552912e-08 | 0.5 | ATG16L1 ATG5 ATG3 ATG12 | Autophagy |
| GO:0000407 | 1.01074594165e-07 | 0.625 | ATG16L2 ATG12 ATG5 ATG3 ATG16L1 | phagophore assembly site |
| WP:WP4577 | 3.04756518364e-07 | 0.5 | ATG16L1 ATG5 ATG3 ATG12 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| KEGG:04140 | 3.51062000799e-07 | 0.625 | ATG16L2 ATG12 ATG5 ATG3 ATG16L1 | Autophagy - animal |
| GO:0034045 | 2.50812007172e-06 | 0.5 | ATG16L2 ATG12 ATG5 ATG16L1 | phagophore assembly site membrane |
| WP:WP5205 | 2.69907043855e-06 | 0.5 | ATG16L1 ATG5 ATG3 ATG12 | Clock controlled autophagy in bone metabolism |
| GO:0005776 | 9.20314592393e-06 | 0.625 | ATG16L2 ATG12 ATG5 TECPR1 ATG16L1 | autophagosome |
| GO:0000045 | 3.03441490958e-05 | 0.625 | ATG16L2 ATG12 ATG5 ATG3 ATG16L1 | autophagosome assembly |
| GO:1905037 | 3.73496867515e-05 | 0.625 | ATG16L2 ATG12 ATG5 ATG3 ATG16L1 | autophagosome organization |
| GO:0016236 | 5.45782856702e-05 | 0.75 | ATG12 ATG16L1 ATG3 ATG5 TECPR1 ATG16L2 | macroautophagy |
| REAC:R-HSA-1632852 | 7.63750276844e-05 | 0.5 | ATG16L1 ATG5 ATG3 ATG12 | Macroautophagy |
| REAC:R-HSA-9612973 | 0.000119991173414 | 0.5 | ATG16L1 ATG5 ATG3 ATG12 | Autophagy |
| KEGG:05131 | 0.000187054370925 | 0.5 | ATG16L1 ATG5 TECPR1 ATG12 | Shigellosis |
| WP:WP5420 | 0.000600074839289 | 0.5 | ATG16L1 ATG5 ATG3 ATG12 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0007033 | 0.000749059118833 | 0.625 | ATG16L2 ATG12 ATG5 ATG3 ATG16L1 | vacuole organization |
| GO:0006914 | 0.00105251385535 | 0.75 | ATG12 ATG16L1 ATG3 ATG5 TECPR1 ATG16L2 | autophagy |
| GO:0061919 | 0.00105251385535 | 0.75 | ATG12 ATG16L1 ATG3 ATG5 TECPR1 ATG16L2 | process utilizing autophagic mechanism |
| REAC:R-HSA-8934903 | 0.00155943355885 | 0.25 | ATG12 ATG5 | Receptor Mediated Mitophagy |
| KEGG:04621 | 0.00260993521755 | 0.375 | ATG16L1 ATG5 ATG12 | NOD-like receptor signaling pathway |
| GO:1901096 | 0.00300428100757 | 0.375 | ATG12 TECPR1 ATG5 | regulation of autophagosome maturation |
| GO:0044804 | 0.00364711882004 | 0.375 | ATG12 ATG3 ATG5 | nucleophagy |
| REAC:R-HSA-5205685 | 0.0116541924374 | 0.25 | ATG12 ATG5 | PINK1-PRKN Mediated Mitophagy |
| GO:0039689 | 0.0131096201623 | 0.25 | ATG16L2 ATG16L1 | negative stranded viral RNA replication |
| GO:0019776 | 0.0131096201623 | 0.25 | ATG5 ATG3 | Atg8-family ligase activity |
| REAC:R-HSA-5205647 | 0.0180115696713 | 0.25 | ATG12 ATG5 | Mitophagy |
| KEGG:04622 | 0.0265361384039 | 0.25 | ATG12 ATG5 | RIG-I-like receptor signaling pathway |
| GO:0000421 | 0.0291427400779 | 0.375 | ATG16L2 TECPR1 ATG16L1 | autophagosome membrane |
| REAC:R-HSA-936440 | 0.02920582473 | 0.25 | ATG12 ATG5 | Negative regulators of DDX58/IFIH1 signaling |
| WP:WP3865 | 0.0337492362996 | 0.25 | ATG12 ATG5 | Novel intracellular components of RIG I like receptor pathway |
| GO:1904973 | 0.0393180950424 | 0.25 | ATG12 ATG5 | positive regulation of viral translation |
| GO:1904971 | 0.0393180950424 | 0.25 | ATG12 ATG5 | regulation of viral translation |
| WP:WP4655 | 0.0489078463283 | 0.25 | ATG12 ATG5 | Cytosolic DNA sensing pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ATG5 | ATG16L1 | 1.0 | 0.128 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM Malo bioplex3_HCT116 fraction |
| ATG5 | TECPR1 | 0.999 | 0.09 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG5 | ATG12 | 0.999 | 0.442 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| ATG16L2 | ATG5 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATG12 | ATG3 | 0.998 | 0.23475 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KAZN | ARHGAP5 | 0.992 | 0.196 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATG12 | ATG16L1 | 0.986 | 0.162761904762 |
mutually_exclusive (Q9H082)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG5 | ATG3 | 0.984 | 0.072 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ATG16L2 | TECPR1 | 0.946 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_WMM WMM_only | |
| ATG3 | ATG16L1 | 0.942 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG16L2 | ATG16L1 | 0.916 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_WMM WMM_only | |
| TECPR1 | ATG16L1 | 0.916 | 0.056 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_WMM WMM_only |
| ATG5 | KAZN | 0.909 | 0.088 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KAZN | ATG16L1 | 0.892 | 0.078 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATG16L2 | ATG12 | 0.779 |
structurally_consistent (Q9H1Y0)
|
bioplex3_WMM WMM_only | |
| ATG12 | TECPR1 | 0.779 | 0.134 | bioplex3_WMM WMM_only | |
| ARHGAP5 | ATG16L1 | 0.076 | 0.046 | bioplex3_WMM WMM_only | |
| ATG5 | ARHGAP5 | 0.076 | 0.074 | bioplex3_WMM WMM_only |
Related Complexes