hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11696.1
Complex Portal: CPX-19831
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CHP2 | Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520) | 5 | UniProt NCBI |
| PRDM1 | PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) | 5 | UniProt NCBI |
| FANCM | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | 5 | UniProt NCBI |
| CENPS | Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain-containing protein 1) (FANCM-associated histone fold protein 1) (FANCM-interacting histone fold protein 1) (Fanconi anemia-associated polypeptide of 16 kDa) | 5 | UniProt NCBI |
| KIZ | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | 5 | UniProt NCBI |
| CFAP68 | Cilia- and flagella-associated protein 68 | 5 | UniProt NCBI |
| CENPX | Centromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog) | 5 | UniProt NCBI |
| FAAP24 | Fanconi anemia core complex-associated protein 24 (Fanconi anemia-associated protein of 24 kDa) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0071821 | 1.84188417064e-09 | 0.5 | FANCM FAAP24 CENPS CENPX | FANCM-MHF complex |
| KEGG:03460 | 3.82593417375e-07 | 0.5 | FANCM FAAP24 CENPS CENPX | Fanconi anemia pathway |
| REAC:R-HSA-6783310 | 4.07608325548e-07 | 0.5 | FANCM FAAP24 CENPS CENPX | Fanconi Anemia Pathway |
| GO:0043240 | 9.10136169988e-07 | 0.5 | FANCM FAAP24 CENPS CENPX | Fanconi anaemia nuclear complex |
| WP:WP4946 | 2.11293894781e-05 | 0.5 | FANCM FAAP24 CENPS CENPX | DNA repair pathways full network |
| CORUM:6145 | 2.39226645298e-05 | 0.25 | CENPX CENPS | CENP-S-X complex |
| GO:0036297 | 7.48923430326e-05 | 0.5 | FANCM FAAP24 CENPS CENPX | interstrand cross-link repair |
| CORUM:6146 | 0.000143457417375 | 0.25 | CENPX CENPS | CENP-T-W-S-X heterotetramer complex |
| GO:0000712 | 0.000644767051209 | 0.375 | FANCM CENPS CENPX | resolution of meiotic recombination intermediates |
| CORUM:6884 | 0.000859567015467 | 0.25 | FANCM FAAP24 | Fanconi anemia FAAP100 complex |
| REAC:R-HSA-73894 | 0.00262653835659 | 0.5 | FANCM FAAP24 CENPS CENPX | DNA Repair |
| GO:0007131 | 0.0487399472212 | 0.375 | FANCM CENPS CENPX | reciprocal meiotic recombination |
| GO:0140527 | 0.0487399472212 | 0.375 | FANCM CENPS CENPX | reciprocal homologous recombination |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CENPS | FANCM | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FANCM | FAAP24 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CENPX | CENPS | 0.998 | 0.186 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CFAP68 | CENPS | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CENPX | FAAP24 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KIZ | PRDM1 | 0.934 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| FANCM | PRDM1 | 0.934 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| KIZ | FANCM | 0.927 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CENPS | FAAP24 | 0.922 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CENPX | CHP2 | 0.915 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CENPX | FANCM | 0.786 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes