hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11697.1
Complex Portal: CPX-17171
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CR2 | Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21) | 5 | UniProt NCBI |
| HEG1 | Protein HEG homolog 1 | 5 | UniProt NCBI |
| GRAMD2A | GRAM domain-containing protein 2A | 5 | UniProt NCBI |
| ASNSD1 | Asparagine synthetase domain-containing protein 1 (HCV NS3-transactivated protein 1) | 3 | UniProt NCBI |
| NECTIN1 | Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111) | 5 | UniProt NCBI |
| ITGA1 | Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) | 5 | UniProt NCBI |
| JAG1 | Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) | 5 | UniProt NCBI |
| FCN2 | Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35) | 5 | UniProt NCBI |
| NUDT18 | 8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18) | 5 | UniProt NCBI |
| PTPRA | Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) | 5 | UniProt NCBI |
| CYB561 | Transmembrane ascorbate-dependent reductase CYB561 (EC 7.2.1.-) (Cytochrome b-561) (Cytochrome b561) | 5 | UniProt NCBI |
| ACE | Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form] | 5 | UniProt NCBI |
| SELENOK | Selenoprotein K (SelK) | 5 | UniProt NCBI |
| MEGF9 | Multiple epidermal growth factor-like domains protein 9 (Multiple EGF-like domains protein 9) (Epidermal growth factor-like protein 5) (EGF-like protein 5) | 4 | UniProt NCBI |
| EFCAB14 | EF-hand calcium-binding domain-containing protein 14 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3413 | 0.00753607712322 | 0.166666666667 | ITGA1 JAG1 | NOTCH1 regulation of endothelial cell calcification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PTPRA | SELENOK | 0.993 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ASNSD1 | PTPRA | 0.981 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CYB561 | PTPRA | 0.976 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HEG1 | ITGA1 | 0.967 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| NECTIN1 | ITGA1 | 0.955 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEG1 | NECTIN1 | 0.954 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACE | MEGF9 | 0.946 | 0.078 | bioplex3_WMM WMM_only | |
| ACE | EFCAB14 | 0.946 | 0.07 | bioplex3_WMM WMM_only | |
| MEGF9 | EFCAB14 | 0.946 | 0.064 | bioplex3_WMM WMM_only | |
| ACE | HEG1 | 0.931 | 0.059 | bioplex3_WMM WMM_only | |
| ACE | ITGA1 | 0.923 | 0.14 | bioplex3_WMM WMM_only | |
| EFCAB14 | ITGA1 | 0.923 | 0.106583333333 | bioplex3_WMM WMM_only | |
| NUDT18 | HEG1 | 0.904 | 0.072 | bioplex3_WMM WMM_only | |
| NUDT18 | FCN2 | 0.902 | bioplex3_WMM WMM_only | ||
| CR2 | NECTIN1 | 0.902 | bioplex3_WMM WMM_only | ||
| CR2 | ITGA1 | 0.902 | 0.141583333333 | bioplex3_WMM WMM_only | |
| ACE | NECTIN1 | 0.902 | 0.13 | bioplex3_WMM WMM_only | |
| CR2 | MEGF9 | 0.902 | bioplex3_WMM WMM_only | ||
| MEGF9 | NECTIN1 | 0.902 | 0.064 | bioplex3_WMM WMM_only | |
| CR2 | ACE | 0.902 | 0.106 | bioplex3_WMM WMM_only | |
| CR2 | EFCAB14 | 0.902 | bioplex3_WMM WMM_only | ||
| NECTIN1 | JAG1 | 0.902 | 0.092 | bioplex3_WMM WMM_only | |
| ACE | JAG1 | 0.902 | 0.198 | bioplex3_WMM WMM_only | |
| FCN2 | HEG1 | 0.902 | bioplex3_WMM WMM_only | ||
| MEGF9 | JAG1 | 0.902 | 0.146 | bioplex3_WMM WMM_only | |
| CR2 | HEG1 | 0.902 | bioplex3_WMM WMM_only | ||
| EFCAB14 | NECTIN1 | 0.902 | 0.054 | bioplex3_WMM WMM_only | |
| CR2 | JAG1 | 0.902 | bioplex3_WMM WMM_only | ||
| EFCAB14 | GRAMD2A | 0.902 | bioplex3_WMM WMM_only | ||
| ACE | PTPRA | 0.897 | 0.11 | bioplex3_WMM WMM_only | |
| CR2 | PTPRA | 0.881 | 0.072 | bioplex3_WMM WMM_only | |
| ITGA1 | PTPRA | 0.877 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEG1 | PTPRA | 0.85 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| NECTIN1 | PTPRA | 0.832 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| MEGF9 | ITGA1 | 0.827 | 0.118 | bioplex3_WMM WMM_only | |
| MEGF9 | HEG1 | 0.826 | 0.112 | bioplex3_WMM WMM_only | |
| MEGF9 | PTPRA | 0.777 | 0.068 | bioplex3_WMM WMM_only | |
| EFCAB14 | HEG1 | 0.776 | 0.052 | bioplex3_WMM WMM_only | |
| EFCAB14 | JAG1 | 0.717 | 0.14 | bioplex3_WMM WMM_only | |
| EFCAB14 | PTPRA | 0.702 | 0.076 | bioplex3_WMM WMM_only | |
| ITGA1 | JAG1 | 0.656 | 0.246 | bioplex3_WMM WMM_only | |
| CYB561 | SELENOK | 0.53 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEG1 | JAG1 | 0.468 | 0.208 | bioplex3_WMM WMM_only | |
| JAG1 | PTPRA | 0.45 | 0.156 | bioplex3_WMM WMM_only | |
| ASNSD1 | SELENOK | 0.333 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| CYB561 | ASNSD1 | 0.172 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| FCN2 | PTPRA | 0.058 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NUDT18 | PTPRA | 0.013 | 0.044 | bioplex3_WMM WMM_only |
Related Complexes