hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11700.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
PIP4P2	Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)	5	UniProt NCBI
GYPB	Glycophorin-B (PAS-3) (SS-active sialoglycoprotein) (Sialoglycoprotein delta) (CD antigen CD235b)	5	UniProt NCBI
BZW1	eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf)	5	UniProt NCBI
KCNN2	Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)	5	UniProt NCBI
EIF2B2	Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)	5	UniProt NCBI
CCDC154	Coiled-coil domain-containing protein 154	2	UniProt NCBI
TMEM167B	Protein kish-B (Transmembrane protein 167B)	5	UniProt NCBI
EIF2B4	Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta)	5	UniProt NCBI
EXOG	Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)	5	UniProt NCBI
ATR	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)	5	UniProt NCBI
ESRRA	Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)	5	UniProt NCBI
OC90	Otoconin-90 (Oc90) (Phospholipase A2 homolog)	4	UniProt NCBI
BZW2	eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2)	5	UniProt NCBI
EIF2B3	Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma)	5	UniProt NCBI
SPN	Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]	5	UniProt NCBI
EIF2B5	Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:7291	2.74936781213e-11	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
CORUM:7292	1.3739312217e-10	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	EIF2B1-EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
REAC:R-HSA-72731	1.03353436073e-08	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	Recycling of eIF2:GDP
GO:0005851	1.31622611039e-07	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	eukaryotic translation initiation factor 2B complex
WP:WP107	1.2691451054e-05	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	Translation factors
GO:0006413	1.70578472096e-05	0.428571428571	EIF2B5 EIF2B4 BZW1 EIF2B3 BZW2 EIF2B2	translational initiation
GO:0014003	6.22418587116e-05	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	oligodendrocyte development
GO:0009408	9.57087558217e-05	0.357142857143	EIF2B3 EIF2B2 EIF2B5 ATR EIF2B4	response to heat
GO:0009266	0.000416966191551	0.357142857143	EIF2B3 EIF2B2 EIF2B5 ATR EIF2B4	response to temperature stimulus
WP:WP5316	0.000631115667297	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	Primary ovarian insufficiency
REAC:R-HSA-72613	0.00106665264962	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	Eukaryotic Translation Initiation
REAC:R-HSA-72737	0.00106665264962	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	Cap-dependent Translation Initiation
GO:0048709	0.00135587822996	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	oligodendrocyte differentiation
GO:0003743	0.00349800823415	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	translation initiation factor activity
GO:0021782	0.00591483348635	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	glial cell development
KEGG:05168	0.0178360232126	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	Herpes simplex virus 1 infection
HP:0000869	0.0200265187635	0.214285714286	EIF2B2 EIF2B3 EIF2B4	Secondary amenorrhea
GO:0008135	0.0232917470649	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	translation factor activity, RNA binding
GO:0006446	0.0246687543338	0.285714285714	BZW1 BZW2 EIF2B5 EIF2B2	regulation of translational initiation
GO:0009749	0.027603729718	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	response to glucose
GO:0009746	0.0307912643026	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	response to hexose
GO:0034284	0.0307912643026	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	response to monosaccharide
GO:0001541	0.0335980618564	0.214285714286	EIF2B2 EIF2B5 EIF2B4	ovarian follicle development
REAC:R-HSA-72766	0.0355285060652	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	Translation
HP:0002352	0.0401413515502	0.285714285714	EIF2B3 EIF2B2 KCNN2 EIF2B4	Leukoencephalopathy
GO:0009743	0.0441393506231	0.285714285714	EIF2B2 EIF2B5 EIF2B3 EIF2B4	response to carbohydrate

Edges

Protein 1	Protein 2	Score	ProteomeHD
EIF2B2	EIF2B5	1.0	0.882
EIF2B3	EIF2B5	1.0	0.932
EIF2B2	EIF2B3	1.0	0.878
EIF2B4	EIF2B2	1.0	0.38
EIF2B4	EIF2B5	1.0	0.472
BZW1	BZW2	0.999	0.286
EXOG	EIF2B2	0.998	0.028
EIF2B4	EIF2B3	0.997	0.436
SPN	ATR	0.987	0.104
BZW1	EIF2B4	0.983	0.11
BZW2	EIF2B3	0.979	0.12
GYPB	EIF2B4	0.972
GYPB	EIF2B3	0.972
BZW1	EIF2B5	0.972	0.152
GYPB	BZW1	0.971
BZW2	EIF2B2	0.971	0.074
TMEM167B	BZW2	0.97	0.12
EXOG	EIF2B5	0.969	0.044
BZW2	EIF2B5	0.967	0.128
SPN	EIF2B3	0.965	0.024
OC90	PIP4P2	0.964
EIF2B2	SPN	0.962	0.042
BZW1	EIF2B3	0.96	0.282
EIF2B4	BZW2	0.954	0.094
EIF2B4	SPN	0.949	0.074
EIF2B3	ATR	0.948	0.166
BZW2	EXOG	0.946	0.022
SPN	EIF2B5	0.94	0.052
GYPB	EIF2B2	0.937
EIF2B5	ATR	0.932	0.222
PIP4P2	EIF2B5	0.925	0.08
BZW1	EIF2B2	0.913	0.208
PIP4P2	EIF2B3	0.897	0.078
EIF2B2	PIP4P2	0.897	0.074
EIF2B4	PIP4P2	0.885	0.074
EIF2B5	KCNN2	0.875
GYPB	BZW2	0.873
GYPB	EIF2B5	0.862
EIF2B3	CCDC154	0.846
EIF2B5	CCDC154	0.846
GYPB	ESRRA	0.839
EIF2B4	ATR	0.813	0.052
EIF2B2	ATR	0.626	0.158
EXOG	EIF2B3	0.599	0.046
EIF2B4	EXOG	0.461	0.044
BZW1	ATR	0.334	0.1
GYPB	ATR	0.311
EXOG	PIP4P2	0.227	0.106
BZW2	ESRRA	0.204	0.17
ESRRA	EIF2B3	0.2	0.086
BZW1	ESRRA	0.187	0.184
BZW2	ATR	0.184	0.056
EIF2B2	ESRRA	0.168	0.072
TMEM167B	EXOG	0.143	0.078
PIP4P2	KCNN2	0.113
ESRRA	ATR	0.11	0.256
ESRRA	EIF2B5	0.087	0.076
EIF2B2	KCNN2	0.078
EIF2B3	KCNN2	0.078
EIF2B4	ESRRA	0.077	0.128
EIF2B4	KCNN2	0.076
EXOG	ATR	0.067	0.036
EXOG	KCNN2	0.043
TMEM167B	EIF2B5	0.036	0.114
BZW1	EXOG	0.031	0.046
TMEM167B	BZW1	0.026	0.09
BZW2	SPN	0.019	0.076
BZW2	PIP4P2	0.014	0.06
EIF2B2	CCDC154	0.011
EIF2B4	CCDC154	0.011
BZW2	CCDC154	0.011
BZW1	CCDC154	0.011
BZW1	PIP4P2	0.01	0.054

Related Complexes

Genename	Complexes
PIP4P2	huMAP3_02588.1 huMAP3_05776.1 huMAP3_09814.1 huMAP3_11108.1 huMAP3_11700.1 huMAP3_12631.1 huMAP3_12809.1
GYPB	huMAP3_00951.1 huMAP3_03018.1 huMAP3_03231.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
BZW1	huMAP3_00951.1 huMAP3_01913.1 huMAP3_03018.1 huMAP3_03231.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_14489.1
KCNN2	huMAP3_11700.1 huMAP3_11977.1
EIF2B2	huMAP3_02090.1 huMAP3_02469.1 huMAP3_02659.1 huMAP3_08184.1 huMAP3_08680.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
CCDC154	huMAP3_11700.1 huMAP3_11977.1 huMAP3_12208.1
TMEM167B	huMAP3_00637.1 huMAP3_06722.1 huMAP3_11700.1
EIF2B4	huMAP3_00951.1 huMAP3_03018.1 huMAP3_05832.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EXOG	huMAP3_02090.1 huMAP3_02469.1 huMAP3_02659.1 huMAP3_08184.1 huMAP3_08570.1 huMAP3_08680.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11700.1
ATR	huMAP3_11232.1 huMAP3_11700.1
ESRRA	huMAP3_02597.1 huMAP3_11313.1 huMAP3_11700.1
OC90	huMAP3_00905.1 huMAP3_02588.1 huMAP3_03803.1 huMAP3_04425.1 huMAP3_05776.1 huMAP3_07771.1 huMAP3_11108.1 huMAP3_11477.1 huMAP3_11700.1 huMAP3_11744.1 huMAP3_11949.1 huMAP3_12631.1 huMAP3_14250.1 huMAP3_15314.1
BZW2	huMAP3_00951.1 huMAP3_02736.1 huMAP3_04876.1 huMAP3_06722.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EIF2B3	huMAP3_03231.1 huMAP3_04876.1 huMAP3_05832.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_12208.1
SPN	huMAP3_02351.1 huMAP3_02659.1 huMAP3_03078.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_08370.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EIF2B5	huMAP3_08184.1 huMAP3_08570.1 huMAP3_08680.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_09399.1 huMAP3_09406.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_11977.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11700.1