hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11701.1
Complex Portal: CPX-15029
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | 5 | UniProt NCBI |
| DCANP1 | Dendritic cell nuclear protein 1 (Dendritic cell nuclear protein-1) (Dendritic cell-associated nuclear protein) | 5 | UniProt NCBI |
| CARNMT1 | Carnosine N-methyltransferase (EC 2.1.1.22) | 5 | UniProt NCBI |
| TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | 5 | UniProt NCBI |
| ZBTB25 | Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP) | 5 | UniProt NCBI |
| LENG9 | Leukocyte receptor cluster member 9 | 2 | UniProt NCBI |
| NR3C2 | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) | 5 | UniProt NCBI |
| TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | 5 | UniProt NCBI |
| MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5268 | 3.76336611262e-10 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TNF-alpha/NF-kappa B signaling complex 7 |
| REAC:R-HSA-937042 | 3.29426179613e-09 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | IRAK2 mediated activation of TAK1 complex |
| REAC:R-HSA-9014325 | 5.17527951477e-09 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TICAM1,TRAF6-dependent induction of TAK1 complex |
| REAC:R-HSA-9645460 | 5.17527951477e-09 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Alpha-protein kinase 1 signaling pathway |
| REAC:R-HSA-975163 | 1.12069648133e-08 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| REAC:R-HSA-937072 | 1.12069648133e-08 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| CORUM:2758 | 1.31072783286e-08 | 0.333333333333 | MAP3K7 TAB1 TAB2 | TAK1 complex |
| REAC:R-HSA-450321 | 3.72634490188e-08 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| REAC:R-HSA-450302 | 7.57954108849e-08 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | activated TAK1 mediates p38 MAPK activation |
| REAC:R-HSA-168638 | 5.60712805559e-07 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | NOD1/2 Signaling Pathway |
| REAC:R-HSA-5357956 | 5.60712805559e-07 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TNFR1-induced NF-kappa-B signaling pathway |
| WP:WP2637 | 7.38691399834e-07 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-445989 | 9.17480125108e-07 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TAK1-dependent IKK and NF-kappa-B activation |
| WP:WP195 | 1.16309507957e-06 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | IL 1 signaling pathway |
| REAC:R-HSA-168643 | 2.534741312e-06 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| REAC:R-HSA-75893 | 4.53970327639e-06 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TNF signaling |
| CORUM:6344 | 4.75490888667e-06 | 0.333333333333 | MAP3K7 TAB1 TAB2 | TNF-R1-associated signaling complex |
| KEGG:04064 | 5.19250512427e-06 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | NF-kappa B signaling pathway |
| REAC:R-HSA-450294 | 5.6894576648e-06 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | MAP kinase activation |
| REAC:R-HSA-448424 | 8.62700529853e-06 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Interleukin-17 signaling |
| KEGG:04668 | 1.0408935525e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TNF signaling pathway |
| WP:WP75 | 1.08792566126e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll like receptor signaling pathway |
| WP:WP231 | 1.14200808527e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TNF alpha signaling pathway |
| REAC:R-HSA-2871837 | 1.87298045635e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | FCERI mediated NF-kB activation |
| REAC:R-HSA-168142 | 2.69008286706e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 2.69008286706e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 2.69008286706e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-975138 | 2.96597360535e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| KEGG:04936 | 3.04292378738e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Alcoholic liver disease |
| REAC:R-HSA-168181 | 3.11158623875e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 3.11158623875e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | MyD88 dependent cascade initiated on endosome |
| WP:WP3851 | 3.36586385976e-05 | 0.333333333333 | MAP3K7 TAB1 TAB2 | TLR4 signaling and tolerance |
| REAC:R-HSA-168138 | 3.74804354083e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-5607764 | 3.92129315961e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-168164 | 4.10045520825e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 4.47704432732e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 4.47704432732e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-166058 | 4.87888020581e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 4.87888020581e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168179 | 5.30705425561e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 5.30705425561e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-9020702 | 5.76267992814e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Interleukin-1 signaling |
| KEGG:04621 | 5.85607695532e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | NOD-like receptor signaling pathway |
| WP:WP4329 | 6.56591297121e-05 | 0.333333333333 | MAP3K7 TAB1 TAB2 | miRNA role in immune response in sepsis |
| CORUM:5215 | 8.20609246787e-05 | 0.222222222222 | TAB1 TAB2 | CS-MAP3K7IP1-MAP3K7IP2 complex |
| REAC:R-HSA-2454202 | 9.13803206472e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-9705671 | 9.47387065173e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| KEGG:05130 | 9.54866913048e-05 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-5621481 | 0.000125027974441 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | C-type lectin receptors (CLRs) |
| REAC:R-HSA-166016 | 0.000138065138157 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 0.00015699295612 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Death Receptor Signaling |
| REAC:R-HSA-446652 | 0.000167151000677 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Interleukin-1 family signaling |
| WP:WP2018 | 0.00022071317957 | 0.333333333333 | MAP3K7 TAB1 TAB2 | RANKL RANK signaling pathway |
| REAC:R-HSA-168898 | 0.000245601040752 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Toll-like Receptor Cascades |
| KEGG:05140 | 0.000303192388334 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Leishmaniasis |
| KEGG:05132 | 0.000322205998393 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Salmonella infection |
| KEGG:05131 | 0.000339656530832 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Shigellosis |
| KEGG:04657 | 0.000583713911688 | 0.333333333333 | MAP3K7 TAB3 TAB2 | IL-17 signaling pathway |
| REAC:R-HSA-9705683 | 0.0007529287167 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | SARS-CoV-2-host interactions |
| KEGG:04620 | 0.000843198484996 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Toll-like receptor signaling pathway |
| KEGG:05145 | 0.000965229215008 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Toxoplasmosis |
| KEGG:05135 | 0.00194722583522 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Yersinia infection |
| KEGG:04380 | 0.00194722583522 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Osteoclast differentiation |
| REAC:R-HSA-9694516 | 0.00330310163066 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | SARS-CoV-2 Infection |
| KEGG:05161 | 0.00413269570012 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Hepatitis B |
| GO:0038061 | 0.00463414518632 | 0.444444444444 | NR3C2 TAB3 MAP3K7 TAB2 | non-canonical NF-kappaB signal transduction |
| WP:WP4666 | 0.00592637242666 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Hepatitis B infection |
| KEGG:05417 | 0.00738827422101 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Lipid and atherosclerosis |
| KEGG:05169 | 0.00738827422101 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Epstein-Barr virus infection |
| KEGG:05170 | 0.00908112215612 | 0.333333333333 | MAP3K7 TAB1 TAB2 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-9679506 | 0.0116205979875 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | SARS-CoV Infections |
| WP:WP4496 | 0.0132604628613 | 0.222222222222 | MAP3K7 TAB1 | Signal transduction through IL1R |
| REAC:R-HSA-449147 | 0.0142295083868 | 0.444444444444 | TAB2 TAB1 MAP3K7 TAB3 | Signaling by Interleukins |
| KEGG:04010 | 0.0179039523177 | 0.333333333333 | MAP3K7 TAB1 TAB2 | MAPK signaling pathway |
| WP:WP382 | 0.0184784380745 | 0.333333333333 | MAP3K7 TAB1 TAB2 | MAPK signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TAB1 | TAB2 | 0.999 | 0.156 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| TAB1 | MAP3K7 | 0.999 | 0.266 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| TAB1 | TAB3 | 0.998 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| CARNMT1 | ZBTB25 | 0.998 | 0.178 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LENG9 | CARNMT1 | 0.998 | 0.076 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TAB2 | MAP3K7 | 0.982 | 0.428 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CARNMT1 | MAP3K7 | 0.977 | 0.074 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ZBTB25 | MAP3K7 | 0.974 | 0.108 |
mutually_exclusive (Q8N4J0)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CARNMT1 | NR3C2 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CARNMT1 | TAB2 | 0.933 | 0.07 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LENG9 | ZBTB25 | 0.914 | 0.064 |
mutually_exclusive (Q8N4J0)
|
bioplex_WMM bioplex3_WMM WMM_only |
| CARNMT1 | DCANP1 | 0.904 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TAB3 | TAB2 | 0.865 | 0.118 |
mutually_exclusive (O43318)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| LENG9 | MAP3K7 | 0.855 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| TAB3 | MAP3K7 | 0.848 | 0.142 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CARNMT1 | TAB1 | 0.846 | 0.054 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LENG9 | TAB1 | 0.655 | 0.157 |
mutually_exclusive (Q8N4J0)
|
bioplex_WMM bioplex3_WMM WMM_only |
| ZBTB25 | TAB1 | 0.532 | 0.05 |
mutually_exclusive (Q8N4J0)
|
bioplex_WMM bioplex3_WMM WMM_only |
| LENG9 | NR3C2 | 0.391 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NR3C2 | ZBTB25 | 0.378 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NR3C2 | MAP3K7 | 0.242 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZBTB25 | TAB2 | 0.242 | 0.096 |
mutually_exclusive (Q8N4J0)
|
bioplex_WMM bioplex3_WMM WMM_only |
| NR3C2 | TAB2 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| LENG9 | TAB2 | 0.215 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only | |
| NR3C2 | TAB1 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes