hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11715.1

Complex Portal: CPX-12218

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
INA	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)	5	UniProt NCBI
DES	Desmin	5	UniProt NCBI
SYNM	Synemin (Desmuslin)	5	UniProt NCBI
NEFL	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)	5	UniProt NCBI
IDE	Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)	5	UniProt NCBI
SPATA22	Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20)	5	UniProt NCBI
GAN	Gigaxonin (Kelch-like protein 16)	5	UniProt NCBI
DCANP1	Dendritic cell nuclear protein 1 (Dendritic cell nuclear protein-1) (Dendritic cell-associated nuclear protein)	5	UniProt NCBI
RSPRY1	RING finger and SPRY domain-containing protein 1	4	UniProt NCBI
NEFM	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	5	UniProt NCBI
KRT7	Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)	5	UniProt NCBI
PRPH	Peripherin (Neurofilament 4)	5	UniProt NCBI
BICDL2	BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B)	4	UniProt NCBI
SYNC	Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)	5	UniProt NCBI
VIM	Vimentin	5	UniProt NCBI
GFAP	Glial fibrillary acidic protein (GFAP)	5	UniProt NCBI
NES	Nestin	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0045103	1.30468176317e-14	0.6	INA NES DES VIM NEFL NEFM SYNC SYNM KRT7	intermediate filament-based process
GO:0005882	6.9420554428e-14	0.6	INA NES DES VIM NEFL NEFM PRPH SYNM KRT7	intermediate filament
GO:0045111	2.78994719337e-12	0.6	INA NES DES VIM NEFL NEFM PRPH SYNM KRT7	intermediate filament cytoskeleton
GO:0045104	4.61166419464e-12	0.533333333333	INA NES DES NEFL NEFM VIM SYNM KRT7	intermediate filament cytoskeleton organization
GO:0045109	5.023768739e-08	0.4	INA DES NEFL NEFM VIM KRT7	intermediate filament organization
GO:0099512	7.5500853999e-07	0.666666666667	SYNC INA NES DES VIM NEFL NEFM PRPH SYNM KRT7	supramolecular fiber
GO:0099081	8.54383345805e-07	0.666666666667	SYNC INA NES DES VIM NEFL NEFM PRPH SYNM KRT7	supramolecular polymer
GO:0099513	2.58207587138e-06	0.6	INA NES DES VIM NEFL NEFM PRPH SYNM KRT7	polymeric cytoskeletal fiber
GO:0005200	1.10222654638e-05	0.4	DES NEFL NEFM SYNM VIM INA	structural constituent of cytoskeleton
GO:0099160	4.37346186898e-05	0.2	NEFL INA NEFM	postsynaptic intermediate filament cytoskeleton
GO:0099080	6.20717863468e-05	0.666666666667	SYNC INA NES DES VIM NEFL NEFM PRPH SYNM KRT7	supramolecular complex
GO:0099571	0.000436807598019	0.2	NEFL INA NEFM	postsynaptic cytoskeleton
WP:WP2447	0.000520544981785	0.2	NEFL NEFM PRPH	Amyotrophic lateral sclerosis ALS
GO:0005198	0.000531695846988	0.533333333333	INA DES VIM NEFL NEFM PRPH SYNM KRT7	structural molecule activity
GO:0005883	0.00244160521127	0.2	NEFL INA NEFM	neurofilament
GO:0019215	0.00522556754165	0.2	SYNM NES VIM	intermediate filament binding
WP:WP5417	0.00945011445255	0.2	NEFL NEFM NES	Cell lineage map for neuronal differentiation

Edges

Protein 1	Protein 2	Score	ProteomeHD
NEFM	DES	1.0	0.054
NEFM	NES	1.0	0.116
PRPH	SYNC	0.999
NEFL	NEFM	0.999	0.236
SYNC	DES	0.999
VIM	DES	0.999	0.238
NEFM	VIM	0.999	0.296
NES	DES	0.998	0.094
INA	NEFM	0.998	0.138
NEFM	SYNC	0.997
SYNC	VIM	0.997
SYNC	BICDL2	0.997
SYNC	SYNM	0.996
NES	VIM	0.994	0.532833333333
INA	DES	0.992	0.05
NEFL	SYNC	0.992
IDE	NES	0.992	0.138
SYNM	DES	0.992	0.066
INA	VIM	0.991	0.325107990434
NEFL	NES	0.99	0.144
NEFL	DES	0.988	0.188
INA	SYNC	0.987
IDE	VIM	0.987	0.194610526316
VIM	GFAP	0.986	0.312
INA	NES	0.984	0.114
KRT7	VIM	0.964	0.402608695652
SYNC	GAN	0.964
RSPRY1	INA	0.963	0.052
NEFL	VIM	0.956	0.286
PRPH	DES	0.949	0.136
RSPRY1	NEFL	0.946	0.104
DES	SPATA22	0.936
DES	GFAP	0.934	0.09
RSPRY1	NEFM	0.917	0.062
INA	GAN	0.915	0.046
RSPRY1	VIM	0.903	0.238555084746
DES	GAN	0.897	0.06
SYNC	NES	0.892
SYNM	NES	0.89	0.142777777778
RSPRY1	NES	0.876	0.026
IDE	DCANP1	0.867
INA	NEFL	0.861	0.158
IDE	NEFM	0.861	0.082
IDE	NEFL	0.859	0.088
INA	GFAP	0.846	0.122
NEFM	GAN	0.825	0.038
IDE	DES	0.81	0.078
IDE	INA	0.808	0.05
SYNC	GFAP	0.766
NES	GFAP	0.76	0.1
NEFM	SYNM	0.678	0.028
GAN	GFAP	0.632	0.106
NEFM	GFAP	0.616	0.066
IDE	GFAP	0.602	0.108
VIM	GAN	0.556	0.165534616038
SYNM	VIM	0.527	0.366
PRPH	BICDL2	0.468
BICDL2	DES	0.401
INA	KRT7	0.38	0.136
RSPRY1	GFAP	0.362	0.092
PRPH	SYNM	0.262	0.112
NEFM	KRT7	0.239	0.226
IDE	KRT7	0.232	0.058
IDE	GAN	0.21	0.04
NEFM	PRPH	0.18	0.136
NEFL	GAN	0.178	0.05
SYNM	GAN	0.176	0.072
BICDL2	VIM	0.173
NES	GAN	0.169	0.076
INA	SYNM	0.167	0.056
PRPH	GAN	0.166	0.074
INA	PRPH	0.159	0.104
KRT7	NES	0.154	0.434
NEFL	SYNM	0.154	0.074
PRPH	VIM	0.153	0.302737226277
NEFL	PRPH	0.146	0.13
BICDL2	SYNM	0.146
PRPH	NES	0.122	0.152777777778
NEFL	GFAP	0.117	0.116
RSPRY1	IDE	0.113	0.09
NEFL	KRT7	0.112	0.2
SYNM	GFAP	0.109	0.08
PRPH	GFAP	0.099	0.06
RSPRY1	SYNM	0.073	0.068
RSPRY1	DES	0.073	0.046
IDE	SYNM	0.046	0.088
INA	BICDL2	0.042
NEFM	BICDL2	0.042
BICDL2	GAN	0.042
NEFL	BICDL2	0.037
VIM	SPATA22	0.034
RSPRY1	GAN	0.021	0.022
VIM	DCANP1	0.021
IDE	PRPH	0.015	0.0780689655172
BICDL2	NES	0.013
BICDL2	GFAP	0.011
KRT7	GFAP	0.009	0.17
IDE	SYNC	0.008
DCANP1	GFAP	0.007
IDE	SPATA22	0.004

Related Complexes

Genename	Complexes
INA	huMAP3_00659.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
DES	huMAP3_06939.1 huMAP3_10960.1 huMAP3_11715.1
SYNM	huMAP3_02709.1 huMAP3_04868.1 huMAP3_06939.1 huMAP3_10960.1 huMAP3_11715.1 huMAP3_12191.1 huMAP3_13447.1
NEFL	huMAP3_00659.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
IDE	huMAP3_00335.1 huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1 huMAP3_11831.1
SPATA22	huMAP3_11440.1 huMAP3_11715.1
GAN	huMAP3_11253.1 huMAP3_11715.1
DCANP1	huMAP3_11701.1 huMAP3_11715.1 huMAP3_11831.1 huMAP3_12513.1 huMAP3_13193.1
RSPRY1	huMAP3_00184.1 huMAP3_00345.1 huMAP3_00765.1 huMAP3_02534.1 huMAP3_04280.1 huMAP3_07174.1 huMAP3_07463.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11715.1
NEFM	huMAP3_00659.1 huMAP3_06794.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
KRT7	huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
PRPH	huMAP3_01544.1 huMAP3_11715.1
BICDL2	huMAP3_02709.1 huMAP3_03177.1 huMAP3_06939.1 huMAP3_09117.1 huMAP3_10960.1 huMAP3_11715.1
SYNC	huMAP3_02709.1 huMAP3_06292.1 huMAP3_06939.1 huMAP3_10960.1 huMAP3_11715.1
VIM	huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
GFAP	huMAP3_11715.1 huMAP3_11732.1
NES	huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11715.1

Complex Portal: CPX-12218