hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11726.1
Complex Portal: CPX-13868
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ORC2 | Origin recognition complex subunit 2 | 5 | UniProt NCBI |
| CARTPT | Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)] | 5 | UniProt NCBI |
| LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | 5 | UniProt NCBI |
| ORC6 | Origin recognition complex subunit 6 | 5 | UniProt NCBI |
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | 5 | UniProt NCBI |
| ALKBH4 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-) | 5 | UniProt NCBI |
| IFI27L1 | Interferon alpha-inducible protein 27-like protein 1 (Interferon-stimulated gene 12c protein) (ISG12(c)) (ISG12C) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5251 | 2.80877722849e-08 | 0.428571428571 | ORC6 ORC2 ORC3 | Ku-ORC complex |
| GO:0000808 | 6.44235965654e-08 | 0.571428571429 | ORC3 LRWD1 ORC2 ORC6 | origin recognition complex |
| GO:0005664 | 6.44235965654e-08 | 0.571428571429 | ORC3 LRWD1 ORC2 ORC6 | nuclear origin of replication recognition complex |
| CORUM:389 | 1.4038119659e-07 | 0.428571428571 | ORC6 ORC2 ORC3 | ORC complex (origin recognition complex) |
| CORUM:1031 | 1.4038119659e-07 | 0.428571428571 | ORC6 ORC2 ORC3 | ORC complex (origin recognition complex) |
| CORUM:1033 | 1.4038119659e-07 | 0.428571428571 | ORC6 ORC2 ORC3 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68689 | 7.29464907751e-07 | 0.428571428571 | ORC6 ORC2 ORC3 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-113507 | 1.09397266507e-06 | 0.428571428571 | ORC6 ORC2 ORC3 | E2F-enabled inhibition of pre-replication complex formation |
| REAC:R-HSA-113510 | 2.00026744108e-05 | 0.428571428571 | ORC6 ORC2 ORC3 | E2F mediated regulation of DNA replication |
| GO:0006270 | 3.29649973093e-05 | 0.571428571429 | ORC3 LRWD1 ORC2 ORC6 | DNA replication initiation |
| CORUM:1032 | 6.1565588648e-05 | 0.285714285714 | ORC2 ORC3 | ORC 2-4 complex (origin recognition 2-4 complex) |
| WP:WP466 | 6.94071614722e-05 | 0.428571428571 | ORC6 ORC2 ORC3 | DNA replication |
| REAC:R-HSA-68962 | 7.07065782066e-05 | 0.428571428571 | ORC6 ORC2 ORC3 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 9.24731829377e-05 | 0.428571428571 | ORC6 ORC2 ORC3 | Activation of ATR in response to replication stress |
| CORUM:1034 | 0.000123103089524 | 0.285714285714 | ORC2 ORC3 | ORC 2-5 complex (origin recognition 2-5 complex) |
| CORUM:1038 | 0.000205125012531 | 0.285714285714 | ORC2 ORC3 | ORC 1-5 complex (origin recognition 1-5 complex) |
| WP:WP45 | 0.0002507595765 | 0.428571428571 | ORC6 ORC2 ORC3 | G1 to S cell cycle control |
| REAC:R-HSA-68616 | 0.000377325314633 | 0.428571428571 | ORC6 ORC2 ORC3 | Assembly of the ORC complex at the origin of replication |
| REAC:R-HSA-68949 | 0.000704018847769 | 0.428571428571 | ORC6 ORC2 ORC3 | Orc1 removal from chromatin |
| REAC:R-HSA-69052 | 0.00150471527401 | 0.428571428571 | ORC6 ORC2 ORC3 | Switching of origins to a post-replicative state |
| WP:WP179 | 0.00150921954183 | 0.428571428571 | ORC6 ORC2 ORC3 | Cell cycle |
| KEGG:04110 | 0.00191594027156 | 0.428571428571 | ORC6 ORC2 ORC3 | Cell cycle |
| REAC:R-HSA-69239 | 0.00348623904287 | 0.428571428571 | ORC6 ORC2 ORC3 | Synthesis of DNA |
| REAC:R-HSA-69206 | 0.00454464074576 | 0.428571428571 | ORC6 ORC2 ORC3 | G1/S Transition |
| REAC:R-HSA-68867 | 0.00454464074576 | 0.428571428571 | ORC6 ORC2 ORC3 | Assembly of the pre-replicative complex |
| REAC:R-HSA-453279 | 0.00656553805866 | 0.428571428571 | ORC6 ORC2 ORC3 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69002 | 0.00656553805866 | 0.428571428571 | ORC6 ORC2 ORC3 | DNA Replication Pre-Initiation |
| REAC:R-HSA-69481 | 0.00830059661954 | 0.428571428571 | ORC6 ORC2 ORC3 | G2/M Checkpoints |
| REAC:R-HSA-69242 | 0.00830059661954 | 0.428571428571 | ORC6 ORC2 ORC3 | S Phase |
| REAC:R-HSA-69306 | 0.0108625713199 | 0.428571428571 | ORC6 ORC2 ORC3 | DNA Replication |
| GO:0006261 | 0.0142054380156 | 0.571428571429 | ORC3 LRWD1 ORC2 ORC6 | DNA-templated DNA replication |
| GO:0000228 | 0.0322799316792 | 0.571428571429 | ORC3 LRWD1 ORC2 ORC6 | nuclear chromosome |
| REAC:R-HSA-69620 | 0.0441050291819 | 0.428571428571 | ORC6 ORC2 ORC3 | Cell Cycle Checkpoints |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ORC2 | LRWD1 | 1.0 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction | |
| ALKBH4 | ORC3 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ALKBH4 | ORC2 | 0.999 | 0.02 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ORC2 | ORC3 | 0.995 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction | ||
| ALKBH4 | LRWD1 | 0.991 | 0.076 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ORC6 | ORC2 | 0.984 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IFI27L1 | ORC6 | 0.979 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ORC2 | CARTPT | 0.958 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ORC3 | CARTPT | 0.95 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ORC6 | LRWD1 | 0.932 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRWD1 | ORC3 | 0.858 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| LRWD1 | CARTPT | 0.755 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ORC6 | ORC3 | 0.417 | Guru fraction |
Related Complexes