hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_11731.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CREB3 | Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)] | 5 | UniProt NCBI |
| CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | 5 | UniProt NCBI |
| ADAMTS13 | A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease) | 5 | UniProt NCBI |
| DECR1 | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1) | 5 | UniProt NCBI |
| CREB3L2 | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | 5 | UniProt NCBI |
| CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4] | 5 | UniProt NCBI |
| PTTG1 | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | 5 | UniProt NCBI |
| PDGFC | Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8874211 | 2.74142964108e-10 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | CREB3 factors activate genes |
| WP:WP5272 | 1.29848862028e-08 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | LDL influence on CD14 and TLR4 |
| KEGG:05215 | 2.16242496936e-08 | 0.625 | CREB3L3 CREB3L4 PDGFC CREB3 CREB3L2 | Prostate cancer |
| WP:WP4756 | 1.548528714e-07 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Renin angiotensin aldosterone system RAAS |
| KEGG:04962 | 1.65353041647e-07 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Vasopressin-regulated water reabsorption |
| KEGG:05030 | 1.83188847291e-07 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Cocaine addiction |
| KEGG:04927 | 2.02427461149e-07 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Cortisol synthesis and secretion |
| WP:WP5085 | 3.04756518364e-07 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Vasopressin regulated water reabsorption |
| KEGG:05031 | 7.12034495753e-07 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Amphetamine addiction |
| KEGG:04918 | 8.78418945546e-07 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Thyroid hormone synthesis |
| KEGG:05166 | 1.16397886914e-06 | 0.625 | CREB3L3 CREB3L4 PTTG1 CREB3 CREB3L2 | Human T-cell leukemia virus 1 infection |
| KEGG:04911 | 1.21827180925e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Insulin secretion |
| KEGG:04925 | 2.06635644055e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Aldosterone synthesis and secretion |
| KEGG:04211 | 2.98324067382e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Longevity regulating pathway |
| KEGG:04916 | 3.29357517638e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Melanogenesis |
| KEGG:04928 | 3.29357517638e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04725 | 4.37036810211e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Cholinergic synapse |
| KEGG:04915 | 4.99807549086e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Estrogen signaling pathway |
| KEGG:04922 | 4.99807549086e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Glucagon signaling pathway |
| KEGG:04668 | 5.69084438069e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | TNF signaling pathway |
| KEGG:04931 | 6.45298240943e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Insulin resistance |
| WP:WP3932 | 6.62432666054e-06 | 0.625 | CREB3L3 CREB3L4 PDGFC CREB3 CREB3L2 | Focal adhesion PI3K Akt mTOR signaling pathway |
| KEGG:04935 | 7.0018002984e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Growth hormone synthesis, secretion and action |
| KEGG:04151 | 7.32253759805e-06 | 0.625 | CREB3L3 CREB3L4 PDGFC CREB3 CREB3L2 | PI3K-Akt signaling pathway |
| WP:WP4321 | 8.8132075112e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Thermogenesis |
| KEGG:04926 | 9.55244968269e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Relaxin signaling pathway |
| KEGG:04728 | 9.91416985426e-06 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Dopaminergic synapse |
| WP:WP4172 | 1.03157414074e-05 | 0.625 | CREB3L3 CREB3L4 PDGFC CREB3 CREB3L2 | PI3K Akt signaling pathway |
| KEGG:04152 | 1.1464262806e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | AMPK signaling pathway |
| KEGG:04261 | 1.41199448839e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-381119 | 1.48598663575e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Unfolded Protein Response (UPR) |
| KEGG:04022 | 1.72100778664e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | cGMP-PKG signaling pathway |
| KEGG:04934 | 1.72100778664e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Cushing syndrome |
| KEGG:05161 | 3.39066033667e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Hepatitis B |
| KEGG:05034 | 3.48342741725e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Alcoholism |
| KEGG:04024 | 4.40594774484e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | cAMP signaling pathway |
| WP:WP4666 | 4.58433749267e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Hepatitis B infection |
| KEGG:05207 | 4.9910919986e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Chemical carcinogenesis - receptor activation |
| KEGG:05203 | 8.45852889263e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Viral carcinogenesis |
| KEGG:05163 | 9.60097664089e-05 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Human cytomegalovirus infection |
| KEGG:04714 | 0.000124666171959 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Thermogenesis |
| KEGG:05020 | 0.000253308138216 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Prion disease |
| KEGG:05016 | 0.000377909756884 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Huntington disease |
| WP:WP45 | 0.000402879316066 | 0.375 | CREB3L3 CREB3 CREB3L4 | G1 to S cell cycle control |
| KEGG:05165 | 0.000521724713369 | 0.5 | CREB3L3 CREB3L4 CREB3 CREB3L2 | Human papillomavirus infection |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CREB3 | PDGFC | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CREB3L3 | CREB3L2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3 | CREB3L2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CREB3L3 | CREB3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3L3 | CREB3L4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ADAMTS13 | PDGFC | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CREB3 | CREB3L4 | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DECR1 | PDGFC | 0.944 | bioplex_WMM bioplex3_WMM WMM_only | |
| DECR1 | CREB3L2 | 0.938 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only |
| DECR1 | PTTG1 | 0.936 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDGFC | CREB3L2 | 0.936 | bioplex_WMM bioplex3_WMM WMM_only | |
| CREB3L4 | PDGFC | 0.904 | bioplex3_WMM WMM_only | |
| DECR1 | CREB3 | 0.887 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CREB3L4 | CREB3L2 | 0.578 | bioplex3_WMM WMM_only | |
| DECR1 | CREB3L4 | 0.245 | bioplex3_WMM WMM_only |
Related Complexes