hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11743.1
Complex Portal: CPX-13867
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ABCD1 | ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) | 5 | UniProt NCBI |
| OCIAD1 | OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen) | 5 | UniProt NCBI |
| PHB2 | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | 5 | UniProt NCBI |
| CCDC127 | Coiled-coil domain-containing protein 127 | 1 | UniProt NCBI |
| AQP5 | Aquaporin-5 (AQP-5) | 5 | UniProt NCBI |
| RMDN3 | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | 5 | UniProt NCBI |
| NIPA2 | Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2) | 4 | UniProt NCBI |
| PHB1 | Prohibitin 1 | 5 | UniProt NCBI |
| RGL4 | Ral-GDS-related protein (hRGR) (Ral guanine nucleotide dissociation stimulator-like 4) (RalGDS-like 4) | 4 | UniProt NCBI |
| INSIG2 | Insulin-induced gene 2 protein (INSIG-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6289 | 0.000273361732609 | 0.222222222222 | PHB2 PHB1 | prohibitin 2 complex, mitochondrial |
| REAC:R-HSA-8949664 | 0.00954313848115 | 0.222222222222 | PHB2 PHB1 | Processing of SMDT1 |
| WP:WP5038 | 0.012380386891 | 0.222222222222 | PHB2 PHB1 | Mitochondrial immune response to SARS CoV 2 |
| GO:0035632 | 0.016855225923 | 0.222222222222 | PHB2 PHB1 | mitochondrial prohibitin complex |
| REAC:R-HSA-8949215 | 0.0183353632609 | 0.222222222222 | PHB2 PHB1 | Mitochondrial calcium ion transport |
| REAC:R-HSA-382551 | 0.0451212027851 | 0.444444444444 | PHB2 AQP5 PHB1 NIPA2 | Transport of small molecules |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PHB1 | PHB2 | 1.0 | 0.974 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| RMDN3 | CCDC127 | 0.992 | 0.146 | hein_WMM bioplex3_WMM hein () | |
| RMDN3 | PHB2 | 0.99 | 0.24 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| RMDN3 | ABCD1 | 0.981 | 0.036 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RGL4 | OCIAD1 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RMDN3 | PHB1 | 0.979 | 0.25 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| OCIAD1 | PHB1 | 0.97 | 0.252 |
structurally_consistent (Q99623)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| CCDC127 | PHB1 | 0.968 | 0.098 | hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OCIAD1 | PHB2 | 0.96 | 0.214 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| PHB1 | ABCD1 | 0.956 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CCDC127 | PHB2 | 0.95 | 0.166 | hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHB2 | ABCD1 | 0.947 | 0.072 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| OCIAD1 | ABCD1 | 0.94 | 0.024 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RMDN3 | OCIAD1 | 0.938 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| NIPA2 | PHB2 | 0.909 | 0.114 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| AQP5 | PHB2 | 0.904 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RMDN3 | INSIG2 | 0.867 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NIPA2 | PHB1 | 0.849 | 0.054 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CCDC127 | ABCD1 | 0.4 | 0.046 | hein_WMM bioplex3_WMM WMM_only | |
| NIPA2 | ABCD1 | 0.097 | 0.088 | bioplex3_WMM WMM_only | |
| CCDC127 | OCIAD1 | 0.063 | 0.176 | hein_WMM WMM_only | |
| RMDN3 | NIPA2 | 0.049 | 0.124 | bioplex3_WMM WMM_only | |
| NIPA2 | OCIAD1 | 0.029 | 0.132 | bioplex_WMM bioplex3_WMM WMM_only | |
| AQP5 | PHB1 | 0.009 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RGL4 | PHB1 | 0.002 | bioplex3_HCT116 WMM_only | ||
| PHB2 | INSIG2 | 0.002 | bioplex3_HCT116 WMM_only | ||
| RGL4 | PHB2 | 0.002 | bioplex3_HCT116 WMM_only | ||
| PHB1 | INSIG2 | 0.001 | bioplex3_HEK293 bioplex3_HCT116 WMM_only |
Related Complexes