hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11748.1

Confidence: Medium

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Genename	Protein Name	Uniprot Annotation Score	Links
CTSO	Cathepsin O (EC 3.4.22.42)	5	UniProt NCBI
GRN	Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]	5	UniProt NCBI
NAPSA	Napsin-A (EC 3.4.23.-) (Aspartyl protease 4) (ASP4) (Asp 4) (Napsin-1) (TA01/TA02)	5	UniProt NCBI
PSAP	Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]	5	UniProt NCBI
SPACA4	Sperm acrosome membrane-associated protein 4 (Sperm acrosomal membrane-associated protein 14)	4	UniProt NCBI
SYT4	Synaptotagmin-4 (Synaptotagmin IV) (SytIV)	5	UniProt NCBI

Showing 1 to 6 of 6 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04142	0.000591179114185	0.5	PSAP NAPSA CTSO	Lysosome
HP:0011813	0.00485499013014	0.333333333333	PSAP GRN	Increased cerebral lipofuscin
HP:0002333	0.0297012565438	0.333333333333	PSAP GRN	Motor deterioration
HP:0030891	0.0467604957305	0.333333333333	PSAP GRN	Periventricular white matter hyperintensities

Showing 1 to 4 of 4 entries

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Protein 1	Protein 2	Score	ProteomeHD	Evidence
PSAP	GRN	0.999	0.084	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CTSO	GRN	0.996		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SYT4	GRN	0.962		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
NAPSA	GRN	0.934	0.09	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SPACA4	GRN	0.896		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CTSO	PSAP	0.888		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PSAP	SYT4	0.16		bioplex_WMM bioplex3_WMM WMM_only

Showing 1 to 7 of 7 entries

Related Complexes

Genename	Complexes
PSAP	huMAP3_03854.1 huMAP3_11748.1 huMAP3_14105.1
GRN	huMAP3_03854.1 huMAP3_11748.1
CTSO	huMAP3_03301.1 huMAP3_11748.1 huMAP3_14105.1
SYT4	huMAP3_03854.1 huMAP3_11748.1
NAPSA	huMAP3_01327.1 huMAP3_11748.1 huMAP3_14645.1
SPACA4	huMAP3_01348.1 huMAP3_08551.1 huMAP3_10208.1 huMAP3_11748.1 huMAP3_12517.1 huMAP3_12818.1