hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_11757.1

Complex Portal: CPX-14638

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
SYMPK	Symplekin	5	UniProt NCBI
P4HA2	Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)	5	UniProt NCBI
CSTF2T	Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64)	5	UniProt NCBI
CPSF4	Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)	5	UniProt NCBI
CPSF4L	Putative cleavage and polyadenylation specificity factor subunit 4-like protein	2	UniProt NCBI
CPSF3	Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)	5	UniProt NCBI
CSTF1	Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50)	4	UniProt NCBI
CPSF2	Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)	5	UniProt NCBI
FIP1L1	Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia)	5	UniProt NCBI
P4HB	Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)	5	UniProt NCBI
P4HA1	Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)	5	UniProt NCBI
CPSF1	Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)	5	UniProt NCBI
WDR33	pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)	5	UniProt NCBI
CSTF3	Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77)	5	UniProt NCBI
CPEB1	Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1)	5	UniProt NCBI
CSTF2	Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005849	3.3821800387e-29	0.8	CSTF3 WDR33 CSTF2T CPSF4L CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	mRNA cleavage factor complex
REAC:R-HSA-77595	1.90079554575e-28	0.733333333333	CSTF3 CSTF2T WDR33 CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	Processing of Intronless Pre-mRNAs
REAC:R-HSA-75067	3.27228756732e-26	0.733333333333	CSTF3 CSTF2T WDR33 CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	Processing of Capped Intronless Pre-mRNA
GO:0005847	2.38542710183e-23	0.666666666667	WDR33 CSTF2T CPSF4L CPSF1 CPSF4 CSTF2 FIP1L1 CPSF3 CPSF2 SYMPK	mRNA cleavage and polyadenylation specificity factor complex
KEGG:03015	4.08483417919e-23	0.8	CSTF3 WDR33 CSTF2T CPSF4L CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	mRNA surveillance pathway
REAC:R-HSA-72187	2.98202027932e-22	0.733333333333	CSTF3 CSTF2T WDR33 CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	mRNA 3'-end processing
REAC:R-HSA-73856	1.53159091004e-21	0.733333333333	CSTF3 CSTF2T WDR33 CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	RNA Polymerase II Transcription Termination
CORUM:1147	1.10699141038e-20	0.466666666667	CSTF3 CPSF3 CSTF2 CSTF1 CPSF1 CPSF2 SYMPK	Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3)
CORUM:1144	2.62526075648e-14	0.333333333333	FIP1L1 CPSF3 CPSF4 CPSF1 CPSF2	Cleavage and polyadenylation factor (CPSF)
REAC:R-HSA-72203	3.14966605931e-14	0.733333333333	CSTF3 CSTF2T WDR33 CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	Processing of Capped Intron-Containing Pre-mRNA
REAC:R-HSA-159231	8.48936242091e-13	0.466666666667	CPSF3 WDR33 CPSF4 FIP1L1 CPSF1 CPSF2 SYMPK	Transport of Mature mRNA Derived from an Intronless Transcript
REAC:R-HSA-159234	1.03414443667e-12	0.466666666667	CPSF3 WDR33 CPSF4 FIP1L1 CPSF1 CPSF2 SYMPK	Transport of Mature mRNAs Derived from Intronless Transcripts
WP:WP411	1.2725740844e-11	0.533333333333	CSTF3 CSTF2T CSTF2 CPSF3 CSTF1 CPSF1 CPSF2 CPSF4	mRNA processing
REAC:R-HSA-72202	1.91187929926e-10	0.466666666667	CPSF3 WDR33 CPSF4 FIP1L1 CPSF1 CPSF2 SYMPK	Transport of Mature Transcript to Cytoplasm
REAC:R-HSA-8953854	7.5127568933e-10	0.733333333333	CSTF3 CSTF2T WDR33 CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	Metabolism of RNA
CORUM:1146	4.24607948444e-08	0.2	CSTF3 CSTF1 CSTF2	Cleavage stimulation factor
GO:0031124	9.52587588503e-08	0.4	CSTF3 CPSF3 WDR33 CPSF1 CPSF2 SYMPK	mRNA 3'-end processing
REAC:R-HSA-73857	1.96750906393e-07	0.733333333333	CSTF3 CSTF2T WDR33 CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	RNA Polymerase II Transcription
CORUM:2211	4.2408504662e-07	0.2	CSTF3 CSTF1 CSTF2	BARD1-BRCA1-CSTF complex
GO:0140513	6.12468130381e-07	0.8	CSTF3 WDR33 CSTF2T CPSF4L CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	nuclear protein-containing complex
GO:0006378	7.05200664571e-07	0.333333333333	CPSF3 WDR33 SYMPK CPSF1 CPSF2	mRNA polyadenylation
REAC:R-HSA-74160	7.55137339213e-07	0.733333333333	CSTF3 CSTF2T WDR33 CPSF1 CPSF4 CSTF2 CSTF1 CPSF3 CPSF2 SYMPK FIP1L1	Gene expression (Transcription)
GO:0031123	7.21895185715e-06	0.4	CSTF3 CPSF3 WDR33 CPSF1 CPSF2 SYMPK	RNA 3'-end processing
GO:0003723	9.88068708491e-06	0.8	CSTF3 CPEB1 CSTF2T WDR33 CPSF1 CSTF2 P4HB FIP1L1 CPSF3 CPSF2 CPSF4 CSTF1	RNA binding
HPA:0301361	0.000335529962644	0.533333333333	CSTF3 WDR33 CSTF2 FIP1L1 P4HB CPSF2 P4HA2 CSTF1	lung; alveolar cells type I[>=Low]
GO:0180012	0.000873077093697	0.2	CSTF3 CPSF3 CPSF1	co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway
REAC:R-HSA-6784531	0.00665382057418	0.2	CPSF1 CPSF4 CSTF2	tRNA processing in the nucleus
HPA:0570792	0.008130184967	0.533333333333	CSTF3 WDR33 P4HA2 FIP1L1 CSTF2 CPSF2 SYMPK CSTF1	testis; round or early spermatids[>=Medium]
HPA:0570762	0.0108590009363	0.533333333333	CSTF3 WDR33 P4HA2 FIP1L1 CSTF2 CPSF2 SYMPK CSTF1	testis; pachytene spermatocytes[>=Medium]
HPA:0301362	0.0162052415306	0.4	CSTF3 CSTF2 CSTF1 P4HB CPSF2 P4HA2	lung; alveolar cells type I[>=Medium]
HPA:0570793	0.0168709461566	0.4	CSTF3 FIP1L1 CSTF2 CPSF2 SYMPK CSTF1	testis; round or early spermatids[High]
CORUM:1257	0.0177655659699	0.133333333333	CPSF2 SYMPK	ALL-1 supercomplex
HPA:0570782	0.0189517377448	0.466666666667	CSTF3 P4HA2 FIP1L1 CSTF2 CPSF2 SYMPK CSTF1	testis; preleptotene spermatocytes[>=Medium]
GO:0003676	0.0259179260221	0.8	CSTF3 CPEB1 CSTF2T WDR33 CPSF1 CSTF2 P4HB FIP1L1 CPSF3 CPSF2 CPSF4 CSTF1	nucleic acid binding
GO:0006397	0.0291517353533	0.4	CSTF3 CPSF3 WDR33 CPSF1 CPSF2 SYMPK	mRNA processing
HPA:0570791	0.0343824663155	0.533333333333	CSTF3 WDR33 P4HA2 FIP1L1 CSTF2 CPSF2 SYMPK CSTF1	testis; round or early spermatids[>=Low]
REAC:R-HSA-72306	0.0387156765307	0.2	CPSF1 CPSF4 CSTF2	tRNA processing
GO:0005654	0.040117662269	0.866666666667	CSTF3 P4HA2 CPEB1 CSTF2T WDR33 CPSF1 SYMPK CSTF2 CSTF1 CPSF3 CPSF2 CPSF4 FIP1L1	nucleoplasm
GO:0005848	0.0491610756088	0.133333333333	CSTF3 CSTF1	mRNA cleavage stimulating factor complex
CORUM:472	0.0498224659463	0.0666666666667	P4HB	Prolyl 4-hydroxylase (alpha(I)-type)
WP:WP4786	0.0499335510824	0.133333333333	P4HB P4HA2	Type I collagen synthesis in the context of osteogenesis imperfecta

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CPSF1	WDR33	1.0	0.574	structurally_consistent (dimer)
CSTF2	SYMPK	1.0	0.692	structurally_consistent (Q12996)
CPSF4	WDR33	1.0	0.428
CSTF3	CSTF2T	1.0	0.122666666667	structurally_consistent (dimer)
CPSF3	CPSF2	1.0	0.814	structurally_consistent (dimer)
CSTF1	CSTF2T	1.0	0.31
CPSF4	CPSF1	1.0	0.568	structurally_consistent (dimer)
CPSF4	FIP1L1	1.0	0.71	mutually_exclusive (Q10570)
CPSF2	CPSF1	1.0	0.728	structurally_consistent (dimer)
CPSF2	FIP1L1	1.0	0.67	mutually_exclusive (Q10570)
CPSF4	CPSF2	1.0	0.714
CPSF3	WDR33	1.0	0.23	structurally_consistent (dimer)
P4HB	P4HA1	1.0	0.246	mixed_interface
CPSF2	WDR33	1.0	0.53	structurally_consistent (Q9UKF6)
CSTF2	CSTF2T	1.0	0.284	mutually_exclusive (Q12996)
FIP1L1	CPSF1	1.0	0.606	structurally_consistent (dimer)
CPSF2	SYMPK	1.0	0.876
CPSF4	CPSF3	0.999	0.736
CPSF4	SYMPK	0.999	0.592
CPSF3	SYMPK	0.999	0.862
CPSF3	CPSF1	0.999	0.644	structurally_consistent (Q9P2I0)
CSTF1	CSTF3	0.999	0.828
P4HA2	P4HA1	0.999	0.134	mixed_interface
P4HA2	WDR33	0.999	0.062
FIP1L1	WDR33	0.999	0.78	mutually_exclusive (Q10570)
WDR33	SYMPK	0.999	0.396
CSTF3	SYMPK	0.999	0.764	structurally_consistent (dimer)
SYMPK	CSTF2T	0.999	0.324	structurally_consistent (Q12996)
SYMPK	CPEB1	0.999
CSTF3	CSTF2	0.998	0.652	structurally_consistent (dimer)
CPSF1	CSTF3	0.996	0.528	structurally_consistent (dimer)
CPSF1	SYMPK	0.996	0.712
FIP1L1	SYMPK	0.996	0.586
P4HA2	P4HB	0.996	0.321	mixed_interface
CPSF4	P4HA1	0.995	0.076
P4HA2	CPSF2	0.995	0.024
FIP1L1	CSTF3	0.994	0.518
P4HB	SYMPK	0.994	0.034
FIP1L1	P4HB	0.993	0.076
CSTF1	FIP1L1	0.992	0.682
CSTF1	CSTF2	0.992	0.546
P4HA2	FIP1L1	0.991	0.042
CPSF2	P4HB	0.991	0.112
P4HA2	CPSF4	0.991	0.03
CPSF2	CSTF3	0.991	0.544
P4HB	WDR33	0.99	0.028
CPSF3	FIP1L1	0.99	0.556
WDR33	CSTF3	0.99	0.416
P4HA2	CPSF1	0.989	0.078
CPSF3	P4HA1	0.988	0.19
CSTF1	P4HA1	0.988	0.128
FIP1L1	P4HA1	0.985	0.136
CPSF4	P4HB	0.983	0.034
CSTF1	P4HB	0.981	0.048
P4HA1	WDR33	0.98	0.086
CSTF1	CPSF2	0.98	0.548
CPSF3	CSTF1	0.98	0.502
P4HA1	CSTF2T	0.979	0.108588235294
FIP1L1	CSTF2	0.978	0.662
CPSF3	CSTF3	0.978	0.572
P4HA1	CSTF3	0.978	0.348925925926
CPSF3	P4HB	0.977	0.12
CPSF2	P4HA1	0.977	0.182235690236
P4HA1	CPSF1	0.977	0.376972222222
CPSF3	CSTF2	0.976	0.484
CPEB1	CSTF2T	0.974
CPSF4	CSTF3	0.973	0.642	structurally_consistent (Q10570)
CPSF4	CSTF2	0.966	0.484
P4HA2	SYMPK	0.965	0.066
P4HB	CSTF3	0.962	0.112
CPSF4	CSTF1	0.961	0.738
CSTF1	WDR33	0.96	0.364
FIP1L1	CSTF2T	0.96	0.324
CSTF1	CPSF1	0.955	0.326
CPSF2	CPSF4L	0.949
FIP1L1	CPSF4L	0.939
P4HA2	CSTF1	0.939	0.05
P4HA2	CSTF3	0.936	0.14
P4HA2	CPSF3	0.934	0.096
CSTF2	CPEB1	0.932
CPSF3	CPSF4L	0.928
WDR33	CSTF2	0.913	0.39
CPSF2	CSTF2	0.912	0.658
CSTF1	SYMPK	0.906	0.376
P4HA1	SYMPK	0.884	0.1864
WDR33	CPSF4L	0.849
P4HB	CSTF2	0.834	0.07
CPSF1	CSTF2	0.815	0.438
CPSF1	CPSF4L	0.814
P4HA2	CSTF2	0.796	0.086
P4HB	CPSF1	0.795	0.124
CPSF4	CSTF2T	0.738	0.148
P4HA1	CSTF2	0.73	0.28
CPSF3	CSTF2T	0.684	0.246
CSTF2	CPSF4L	0.488
P4HA2	CSTF2T	0.334	0.006
CPSF2	CPEB1	0.316
WDR33	CSTF2T	0.314	0.136
FIP1L1	CPEB1	0.303
P4HA1	CPSF4L	0.301
CPSF2	CSTF2T	0.286	0.262
P4HB	CSTF2T	0.271	0.05
P4HA2	CPSF4L	0.11
CPSF1	CSTF2T	0.086	0.364
CPSF1	CPEB1	0.04
P4HB	CPSF4L	0.029
CPSF3	CPEB1	0.019
WDR33	CPEB1	0.016
CPSF4	CPEB1	0.015
CSTF3	CPEB1	0.014
CSTF1	CPEB1	0.012
P4HA1	CPEB1	0.003
P4HB	CPEB1	0.001

Related Complexes

Genename	Complexes
SYMPK	huMAP3_02980.1 huMAP3_05545.1 huMAP3_09096.1 huMAP3_11757.1
P4HA2	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1
CSTF2T	huMAP3_05545.1 huMAP3_09096.1 huMAP3_11757.1
CPSF4	huMAP3_00102.1 huMAP3_09096.1 huMAP3_09559.1 huMAP3_10074.1 huMAP3_11757.1 huMAP3_15022.1
CPSF4L	huMAP3_02735.1 huMAP3_11757.1
CPSF3	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_14094.1
CSTF1	huMAP3_00102.1 huMAP3_03810.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09096.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_11757.1 huMAP3_14584.1
CPSF2	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_15022.1
FIP1L1	huMAP3_00102.1 huMAP3_08087.1 huMAP3_08486.1 huMAP3_09096.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_11073.1 huMAP3_11757.1
P4HB	huMAP3_00102.1 huMAP3_04071.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_12074.1
P4HA1	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1
CPSF1	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1
WDR33	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_15022.1
CSTF3	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1
CPEB1	huMAP3_02980.1 huMAP3_05545.1 huMAP3_09096.1 huMAP3_11370.1 huMAP3_11674.1 huMAP3_11757.1 huMAP3_12858.1
CSTF2	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_11757.1

Complex Portal: CPX-14638