hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11767.1
Complex Portal: CPX-16497
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LY6D | Lymphocyte antigen 6D (Ly-6D) (E48 antigen) | 5 | UniProt NCBI |
| OSGEPL1 | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase-like protein 1) (OSGEP-like protein 1) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1) | 5 | UniProt NCBI |
| ACY3 | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC 3.5.1.114) (Acylase III) (Aminoacylase-3) (ACY-3) (Aspartoacylase-2) (Hepatitis C virus core-binding protein 1) (HCBP1) (HCV core-binding protein 1) | 5 | UniProt NCBI |
| DAGLA | Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) | 5 | UniProt NCBI |
| KCNQ5 | Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5) | 5 | UniProt NCBI |
| MCOLN1 | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) | 5 | UniProt NCBI |
| MCOLN3 | Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3) | 5 | UniProt NCBI |
| MCOLN2 | Mucolipin-2 (Transient receptor potential channel mucolipin 2) (TRPML2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3295583 | 1.55196545534e-05 | 0.375 | MCOLN2 MCOLN1 MCOLN3 | TRP channels |
| GO:0072345 | 5.37995977657e-05 | 0.375 | MCOLN2 MCOLN1 MCOLN3 | NAADP-sensitive calcium-release channel activity |
| REAC:R-HSA-2672351 | 0.000984685646855 | 0.375 | MCOLN2 MCOLN1 MCOLN3 | Stimuli-sensing channels |
| GO:0015278 | 0.00118146610329 | 0.375 | MCOLN2 MCOLN1 MCOLN3 | calcium-release channel activity |
| KEGG:04020 | 0.00425211135478 | 0.375 | MCOLN2 MCOLN1 MCOLN3 | Calcium signaling pathway |
| GO:0099604 | 0.0043754188034 | 0.375 | MCOLN2 MCOLN1 MCOLN3 | ligand-gated calcium channel activity |
| REAC:R-HSA-983712 | 0.00688574644986 | 0.375 | MCOLN2 MCOLN1 MCOLN3 | Ion channel transport |
| GO:0005217 | 0.00712601113833 | 0.375 | MCOLN2 MCOLN1 MCOLN3 | intracellular ligand-gated monoatomic ion channel activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MCOLN2 | MCOLN3 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MCOLN1 | MCOLN3 | 0.999 |
mutually_exclusive (Q8IZK6)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ACY3 | MCOLN3 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MCOLN1 | LY6D | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DAGLA | MCOLN3 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MCOLN1 | MCOLN2 | 0.971 |
mutually_exclusive (Q8TDD5)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LY6D | MCOLN2 | 0.971 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| KCNQ5 | MCOLN3 | 0.964 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MCOLN2 | OSGEPL1 | 0.904 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MCOLN2 | ACY3 | 0.768 | bioplex3_WMM WMM_only | ||
| DAGLA | KCNQ5 | 0.353 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MCOLN1 | ACY3 | 0.343 | bioplex3_WMM WMM_only | ||
| MCOLN2 | DAGLA | 0.224 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MCOLN1 | DAGLA | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MCOLN1 | KCNQ5 | 0.215 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| MCOLN2 | KCNQ5 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MCOLN1 | OSGEPL1 | 0.095 | 0.06 | bioplex3_WMM WMM_only | |
| DAGLA | ACY3 | 0.046 | bioplex3_WMM WMM_only | ||
| KCNQ5 | ACY3 | 0.043 | bioplex3_WMM WMM_only |
Related Complexes