hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11777.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NANOS1 | Nanos homolog 1 (NOS-1) (EC_Rep1a) | 5 | UniProt NCBI |
| FAM3D | Protein FAM3D | 3 | UniProt NCBI |
| PEX14 | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | 5 | UniProt NCBI |
| AHSP | Alpha-hemoglobin-stabilizing protein (Erythroid differentiation-related factor) (Erythroid-associated factor) | 5 | UniProt NCBI |
| PHYH | Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH) | 5 | UniProt NCBI |
| PEX5 | Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0010571 | 1.07472199296e-05 | 0.5 | PEX5 PEX14 PHYH | Elevated circulating phytanic acid concentration |
| HP:0010965 | 1.07472199296e-05 | 0.5 | PEX5 PEX14 PHYH | Abnormal circulating phytanic acid concentration |
| HP:0010964 | 1.65290903262e-05 | 0.5 | PEX5 PEX14 PHYH | Abnormal circulating long-chain fatty-acid concentration |
| KEGG:04146 | 8.21377308095e-05 | 0.5 | PEX5 PEX14 PHYH | Peroxisome |
| HP:0004359 | 0.000575493098093 | 0.5 | PEX5 PEX14 PHYH | Abnormal circulating fatty-acid concentration |
| HP:0001088 | 0.00711805296098 | 0.333333333333 | PEX14 PEX5 | Brushfield spots |
| HP:0008064 | 0.00857286967155 | 0.5 | PEX5 PEX14 PHYH | Ichthyosis |
| HP:0008167 | 0.011317974846 | 0.333333333333 | PEX14 PEX5 | Very long chain fatty acid accumulation |
| HP:0002652 | 0.0186233915395 | 0.5 | PEX5 PEX14 PHYH | Skeletal dysplasia |
| GO:0016560 | 0.0210651876021 | 0.333333333333 | PEX14 PEX5 | protein import into peroxisome matrix, docking |
| HP:0000662 | 0.0261590153267 | 0.5 | PEX5 PEX14 PHYH | Nyctalopia |
| REAC:R-HSA-9033241 | 0.0288812004442 | 0.333333333333 | PEX14 PHYH | Peroxisomal protein import |
| HP:0000510 | 0.0313233529835 | 0.5 | PEX5 PEX14 PHYH | Rod-cone dystrophy |
| HP:0011040 | 0.0322780794397 | 0.333333333333 | PEX14 PEX5 | Abnormal intrahepatic bile duct morphology |
| GO:0016561 | 0.042122686785 | 0.333333333333 | PEX14 PEX5 | protein import into peroxisome matrix, translocation |
| CORUM:1984 | 0.0499436884912 | 0.166666666667 | PEX14 | PEX14 homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PHYH | PEX5 | 0.967 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PEX14 | PHYH | 0.961 | 0.082 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| NANOS1 | PHYH | 0.953 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PEX5 | FAM3D | 0.919 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PEX14 | PEX5 | 0.871 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PEX5 | AHSP | 0.816 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PEX14 | AHSP | 0.216 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PEX14 | FAM3D | 0.202 | 0.036 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| PEX14 | NANOS1 | 0.022 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes