hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11788.1
Complex Portal: CPX-10563
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ADAM11 | Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC) | 5 | UniProt NCBI |
| ADAM22 | Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) | 5 | UniProt NCBI |
| LGI1 | Leucine-rich glioma-inactivated protein 1 (Epitempin-1) | 5 | UniProt NCBI |
| IGFL3 | Insulin growth factor-like family member 3 | 3 | UniProt NCBI |
| ADAM23 | Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5682910 | 8.9672682252e-11 | 0.8 | ADAM23 ADAM11 ADAM22 LGI1 | LGI-ADAM interactions |
| CORUM:7395 | 1.36501667663e-05 | 0.4 | ADAM22 LGI1 | ADAM22-LGI1 complex |
| REAC:R-HSA-1266738 | 0.00896294496653 | 0.8 | ADAM23 ADAM11 ADAM22 LGI1 | Developmental Biology |
| HP:0002266 | 0.0358235710582 | 0.4 | ADAM22 LGI1 | Focal clonic seizure |
| HP:0007334 | 0.0497672375822 | 0.4 | ADAM22 LGI1 | Bilateral tonic-clonic seizure with focal onset |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ADAM23 | LGI1 | 0.988 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| IGFL3 | ADAM23 | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ADAM22 | LGI1 | 0.984 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| IGFL3 | ADAM11 | 0.92 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ADAM23 | ADAM11 | 0.822 |
mutually_exclusive (O95970)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ADAM22 | ADAM11 | 0.091 |
mutually_exclusive (O95970)
|
bioplex3_WMM WMM_only | |
| ADAM23 | ADAM22 | 0.078 |
mutually_exclusive (O95970)
|
bioplex3_WMM WMM_only |
Related Complexes